{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:53:16Z","timestamp":1772841196515,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Considering the diagnostic limitations of cfDNA-based noninvasive prenatal testing (NIPT), scientists have long been interested in isolating and analyzing rare intact fetal and trophoblast cells from maternal blood or endocervical samples to diagnose fetal genetic conditions. These cells may be scarce and difficult to isolate, but they are a direct source of pure fetal genetic material. In this review, we summarize the history of cell-based NIPT, present an updated review on its current developments, evaluate its genetic diagnostic potential, and discuss its future prospects for clinical use.<\/jats:p>","DOI":"10.1097\/grf.0000000000000798","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T15:41:24Z","timestamp":1693496484000},"page":"636-648","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Cell-based Noninvasive Prenatal Testing (cbNIPT)\u2014A Review on the Current Developments and Future Prospects"],"prefix":"10.1097","volume":"66","author":[{"given":"Mohamad Ali","family":"Maktabi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Vossaert","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignatia B.","family":"Van den Veyver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology"},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"R1-20250512","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1097\/AOG.0000000000004084","volume":"136","year":"2020","journal-title":"Obstet Gynecol"},{"key":"R2-20250512","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/uog.20353","article-title":"Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis","volume":"54","author":"Salomon","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"R3-20250512","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"R4-20250512","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/uog.17484","article-title":"Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis","volume":"50","author":"Gil","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"R5-20250512","doi-asserted-by":"crossref","first-page":"102 e1","DOI":"10.1016\/j.ajog.2015.04.005","article-title":"Utilization of noninvasive prenatal testing: impact on referrals for diagnostic testing","volume":"213","author":"Williams","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"R6-20250512","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/pd.5620","article-title":"Fetal fraction and noninvasive prenatal testing: What clinicians need to know","volume":"40","author":"Hui","year":"2020","journal-title":"Prenat Diagn"},{"key":"R7-20250512","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/pd.5957","article-title":"Overview and recent developments in cell-based noninvasive prenatal testing","volume":"41","author":"Vossaert","year":"2021","journal-title":"Prenat Diagn"},{"key":"R8-20250512","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/clinchem\/hvaa304","article-title":"Forever connected: The Lifelong biological consequences of fetomaternal and maternofetal microchimerism","volume":"67","author":"Bianchi","year":"2021","journal-title":"Clin Chem"},{"key":"R9-20250512","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1073\/pnas.87.9.3279","article-title":"Isolation of fetal DNA from nucleated erythrocytes in maternal blood","volume":"87","author":"Bianchi","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R10-20250512","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/pd.5295","article-title":"Biology of human primitive erythroblasts for application in noninvasive prenatal diagnosis","volume":"38","author":"Huang","year":"2018","journal-title":"Prenat Diagn"},{"key":"R11-20250512","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/pd.347","article-title":"Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. 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