{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:30:27Z","timestamp":1791909027856,"version":"4.3.4"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1097\/grf.0b013e31811eba5e","type":"journal-article","created":{"date-parts":[[2007,7,13]],"date-time":"2007-07-13T08:26:05Z","timestamp":1184315165000},"page":"624-635","source":"Crossref","is-referenced-by-count":28,"title":["Hypothermia as a Treatment for Birth Asphyxia"],"prefix":"10.1097","volume":"50","author":[{"given":"SEETHA","family":"SHANKARAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ABBOT R.","family":"LAPTOOK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210126","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00008480-200004000-00004","article-title":"Cerebral hypothermia for prevention of brain injury following perinatal asphyxia","volume":"12","author":"Gunn","year":"2000","journal-title":"Curr Opin Pediatr"},{"key":"R2-9-20210126","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","article-title":"Interventions for perinatal hypoxic-ischemic encephalopathy","volume":"100","author":"Vanucci","year":"1997","journal-title":"Pediatrics"},{"key":"R3-9-20210126","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3476(89)80132-5","article-title":"School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term","volume":"114","author":"Roberston","year":"1989","journal-title":"J Pediatr"},{"key":"R4-9-20210126","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","article-title":"Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants","volume":"25","author":"Shankaran","year":"1991","journal-title":"Early Hum Dev"},{"key":"R5-9-20210126","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/mrdd.10037","article-title":"The epidemiology of cerebral palsy in term infants","volume":"8","author":"Nelson","year":"2002","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"R6-9-20210126","first-page":"277","article-title":"Neurology of the Newborn","author":"Volpe","year":"2000"},{"key":"R7-9-20210126","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","article-title":"Delayed (\u201csecondary\u201d) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy","volume":"36","author":"Lorek","year":"1994","journal-title":"Pediatr Res"},{"key":"R8-9-20210126","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1161\/01.STR.23.10.1504","article-title":"Glucose-associated alterations in ischemic brain metabolism of neonatal piglets","volume":"23","author":"Laptook","year":"1992","journal-title":"Stroke"},{"key":"R9-9-20210126","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1203\/00006450-200106000-00003","article-title":"Neurobiology of hypoxic-ischemic injury in the developing brain","volume":"49","author":"Johnston","year":"2001","journal-title":"Pediatr Res"},{"key":"R10-9-20210126","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/jcbfm.1989.20","article-title":"Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis","volume":"9","author":"Siesjo","year":"1989","journal-title":"J Cereb Blood Flow Metab"},{"key":"R11-9-20210126","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1203\/00006450-199705000-00001","article-title":"Reperfusion injury as the mechanism of brain damage after perinatal asphyxia","volume":"41","author":"Fellman","year":"1997","journal-title":"Pediatr Res"},{"key":"R12-9-20210126","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/00004647-199910000-00006","article-title":"Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage","volume":"19","author":"Liu","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"R13-9-20210126","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(94)90574-6","article-title":"Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult","volume":"181","author":"Mehmet","year":"1994","journal-title":"Neurosci Lett"},{"key":"R14-9-20210126","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1203\/00006450-199605000-00008","article-title":"Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep","volume":"39","author":"Tan","year":"1996","journal-title":"Pediatr Res"},{"key":"R15-9-20210126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0303-7207(98)00035-5","article-title":"Asphyxial brain injury\u2014the role of the IGF system","volume":"140","author":"Gluckman","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"R16-9-20210126","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"J Clin Invest"},{"key":"R17-9-20210126","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"R18-9-20210126","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1203\/00006450-199909000-00005","article-title":"Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep","volume":"46","author":"Gunn","year":"1999","journal-title":"Pediatr Res"},{"key":"R19-9-20210126","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000047105","article-title":"Pharmacotherapeutical reduction of post-hypoxic-ischemic brain injury in the newborn","volume":"79","author":"Peeters","year":"2001","journal-title":"Biol Neonate"},{"key":"R20-9-20210126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/siny.2001.0042","article-title":"Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention","volume":"6","author":"Gluckman","year":"2001","journal-title":"Semin Neonatol"},{"key":"R21-9-20210126","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/01.STR.0000128029.50221.fa","article-title":"Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats","volume":"35","author":"Liu","year":"2004","journal-title":"Stroke"},{"key":"R22-9-20210126","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.nbd.2005.05.019","article-title":"Topiramate prevents excitotoxic damage in the newborn rodent brain","volume":"20","author":"Sfaello","year":"2005","journal-title":"Neurobiol Dis"},{"key":"R23-9-20210126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/micr.10163","article-title":"Intestinal ischemia and reperfusion injury in growing rats: hypothermia and N-acetylcysteine modulation","volume":"23","author":"Montero","year":"2003","journal-title":"Microsurgery"},{"key":"R24-9-20210126","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1203\/01.pdr.0000215045.91122.44","article-title":"Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats","volume":"59","author":"Jatana","year":"2006","journal-title":"Pediatr Res"},{"key":"R25-9-20210126","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1203\/00006450-199512000-00015","article-title":"Quantitative relationship between brain temperature and energy utilization rate measured in vivo using 31P and 1H magnetic resonance spectroscopy","volume":"38","author":"Laptook","year":"1995","journal-title":"Pediatr Res"},{"key":"R26-9-20210126","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1097\/00001756-199710200-00033","article-title":"Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins","volume":"8","author":"Thoresen","year":"1997","journal-title":"Neuroreport"},{"key":"R27-9-20210126","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1006\/bbrc.1995.2895","article-title":"Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia","volume":"217","author":"Edwards","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"R28-9-20210126","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0006-8993(01)02659-2","article-title":"Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia","volume":"910","author":"Fukuda","year":"2001","journal-title":"Brain Res"},{"key":"R29-9-20210126","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00229658","article-title":"Postischaemic changes in protein synthesis in the rat brain: effects of hypothermia","volume":"95","author":"Bergstedt","year":"1993","journal-title":"Exp Brain Res"},{"key":"R30-9-20210126","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1046\/j.1471-4159.1995.65031250.x","article-title":"Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation","volume":"65","author":"Globus","year":"1995","journal-title":"J Neurochem"},{"key":"R31-9-20210126","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/neu.1995.12.159","article-title":"Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat","volume":"12","author":"Goss","year":"1995","journal-title":"J Neurotrauma"},{"key":"R32-9-20210126","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatr Res"},{"key":"R33-9-20210126","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1203\/00006450-200203000-00015","article-title":"Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats","volume":"51","author":"Wagner","year":"2002","journal-title":"Pediatr Res"},{"key":"R34-9-20210126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1203\/00006450-200201000-00005","article-title":"Improved neuroprotection with hypothermia delayed by 6 hours following cerebral hypoxia-ischemia in the 14-day-old rat","volume":"51","author":"Taylor","year":"2002","journal-title":"Pediatr Res"},{"key":"R35-9-20210126","first-page":"1333","article-title":"The asymptomatic newborn and risk of cerebral palsy","volume":"141","author":"Nelson","year":"1987","journal-title":"Am J Dis Child"},{"key":"R36-9-20210126","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1542\/peds.82.2.240","article-title":"Intrapartum asphyxia and cerebral palsy","volume":"82","author":"Freeman","year":"1988","journal-title":"Pediatrics"},{"key":"R37-9-20210126","first-page":"1103","article-title":"Pathologic fetal acidemia","volume":"78","author":"Goldaber","year":"1991","journal-title":"Obstet Gynecol"},{"key":"R38-9-20210126","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0022-3476(88)80023-4","article-title":"Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome","volume":"113","author":"Perlman","year":"1988","journal-title":"J Pediatr"},{"key":"R39-9-20210126","first-page":"187","article-title":"Guidelines for Perinatal Care-5th edition","year":"2002"},{"key":"R40-9-20210126","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.1997.03550030047032","article-title":"Maternal infection and cerebral palsy in infants of normal birth weight","volume":"278","author":"Grether","year":"1997","journal-title":"JAMA"},{"key":"R41-9-20210126","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1542\/peds.110.4.673","article-title":"Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants","volume":"110","author":"Shalak","year":"2002","journal-title":"Pediatrics"},{"key":"R42-9-20210126","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"R43-9-20210126","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.106.4.684","article-title":"Pilot study of treatment with whole body hypothermia for neonatal encephalopathy","volume":"106","author":"Azzopardi","year":"2000","journal-title":"Pediatrics"},{"key":"R44-9-20210126","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/peds.106.1.92","article-title":"Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy","volume":"106","author":"Thoresen","year":"2000","journal-title":"Pediatrics"},{"key":"R45-9-20210126","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.110.2.377","article-title":"Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants","volume":"110","author":"Shankaran","year":"2002","journal-title":"Pediatrics"},{"key":"R46-9-20210126","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1469-8749.2003.tb00854.x","article-title":"Whole-body cooling after perinatal asphyxia: a pilot study in term neonates","volume":"45","author":"Debillon","year":"2003","journal-title":"Dev Med Child Neurol"},{"key":"R47-9-20210126","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pediatrneurol.2004.06.015","article-title":"Moderate hypothermia in neonatal encephalopathy: safety outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatr Neurol"},{"key":"R48-9-20210126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2004.06.014","article-title":"Moderate hypothermia in neonatal encephalopathy: efficacy outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatr Neurol"},{"key":"R49-9-20210126","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"R50-9-20210126","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"R51-9-20210126","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpeds.2005.12.009","article-title":"Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop","volume":"148","author":"Higgins","year":"2006","journal-title":"J Pediatr"},{"key":"R52-9-20210126","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1542\/peds.2006-1591","article-title":"Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy","volume":"118","author":"Ambalavanan","year":"2006","journal-title":"Pediatrics"},{"key":"R53-9-20210126","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archpedi.160.7.729","article-title":"Postasphyxial hypoxic-ischemic encephalopathy in neonates. Outcome prediction rule within 4 hours of birth","volume":"160","author":"Shah","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R54-9-20210126","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1542\/peds.108.5.1103","article-title":"Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling","volume":"108","author":"Laptook","year":"2001","journal-title":"Pediatrics"}],"container-title":["Clinical Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003081-200709000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T09:19:21Z","timestamp":1683969561000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003081-200709000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/grf.0b013e31811eba5e","relation":{},"ISSN":["0009-9201"],"issn-type":[{"value":"0009-9201","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}