{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:31:22Z","timestamp":1786120282661,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1097\/grf.0b013e3182353d0f","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T05:15:01Z","timestamp":1319606101000},"page":"685-695","source":"Crossref","is-referenced-by-count":76,"title":["Use of the Aromatase Inhibitor Letrozole for Ovulation Induction in Women With Polycystic Ovarian Syndrome"],"prefix":"10.1097","volume":"54","author":[{"given":"ROBERT F.","family":"CASPER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOHAMED F.M.","family":"MITWALLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210126","first-page":"262","article-title":"The use of clomiphene in the treatment of infertility due to ovarian dysfunction.","volume":"71","author":"Payne","year":"1963","journal-title":"West J Surg Obstet Gynecol"},{"key":"R2-19-20210126","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0015-0282(16)35041-5","article-title":"Clomiphene citrate: further observations on its use in induction of ovulation in human and its mode of action.","volume":"14","author":"Roy","year":"1963","journal-title":"Fertil Steril"},{"key":"R3-19-20210126","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0015-0282(98)00537-8","article-title":"Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.","volume":"7","author":"Young","year":"1999","journal-title":"Fertil Steril"},{"key":"R4-19-20210126","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0015-0282(16)48069-6","article-title":"Clomiphene citrate: mechanism(s) and site(s) of action: a hypothesis revisited.","volume":"42","author":"Adashi","year":"1984","journal-title":"Fertil Steril"},{"key":"R5-19-20210126","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1210\/endo-110-6-2219","article-title":"Direct enhancement of gonadotropin-stimulated ovarian estrogen biosynthesis by estrogen and clomiphene citrate.","volume":"110","author":"Zhuang","year":"1982","journal-title":"Endocrinology"},{"key":"R6-19-20210126","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0015-0282(02)03241-7","article-title":"A randomized double blind comparison of the effects of clomiphene citrate and the AI letrozole on ovulatory function in normal women.","volume":"78","author":"Fisher","year":"2002","journal-title":"Fertil Steril"},{"key":"R8-19-20210126","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0015-0282(16)42670-1","article-title":"The use of clomiphene citrate.","volume":"28","author":"Garcia","year":"1977","journal-title":"Fertil Steril"},{"key":"R10-19-20210126","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archopht.1995.01100040102034","article-title":"Visual disturbance secondary to clomiphene citrate.","volume":"113","author":"Purvin","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"R12-19-20210126","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000292554","article-title":"Exogenous estrogen therapy concurrent with clomiphene citrate: lack of effect on serum sex hormones and endometrial thickness.","volume":"37","author":"Ben-Ami","year":"1994","journal-title":"Gynecol Obstet Invest"},{"key":"R13-19-20210126","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/oxfordjournals.humrep.a137165","article-title":"Sonographic Determination of an Adverse Effect of Clomiphene Citrate on Endometrial Growth.","volume":"5","author":"Gonen","year":"1990","journal-title":"Hum Reprod"},{"key":"R14-19-20210126","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0015-0282(16)53472-4","article-title":"Clomiphene citrate directly impairs endometrial receptivity in the mouse.","volume":"53","author":"Nelson","year":"1990","journal-title":"Fertil Steril"},{"key":"R15-19-20210126","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1471-0528.1992.tb13708.x","article-title":"A prospective, randomised, cross-over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal fertile women.","volume":"99","author":"Li","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"key":"R16-19-20210126","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0015-0282(16)55973-1","article-title":"Clomiphene citrate affects cervical mucus and endometrial morphology independently of the changes in plasma hormonal levels induced by multiple follicular recruitment.","volume":"59","author":"Massai","year":"1993","journal-title":"Fertil Steril"},{"key":"R18-19-20210126","first-page":"89","article-title":"Severe ovarian hyperstimulation syndrome: case reports.","volume":"19","author":"Magnus","year":"1988","journal-title":"Acta Eur Fertil"},{"key":"R19-19-20210126","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.fertnstert.2006.03.014","article-title":"Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate.","volume":"85","author":"Tulandi","year":"2006","journal-title":"Fertility and Sterility"},{"key":"R20-19-20210126","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1021\/jm00173a001","article-title":"Mechanism and inhibition of cytochrome P-450 aromatase.","volume":"33","author":"Cole","year":"1990","journal-title":"J Med Chem"},{"key":"R21-19-20210126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/edrv-11-2-221","article-title":"Endocrine treatment of breast cancer in women.","volume":"11","author":"Santen","year":"1990","journal-title":"Endocrine Rev"},{"key":"R22-19-20210126","first-page":"244","article-title":"Aromatase inhibition: a novel method of ovulation induction in women with polycystic ovary syndrome.","volume":"10","author":"Mitwally","year":"2000","journal-title":"Reprod Technol"},{"key":"R23-19-20210126","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0015-0282(00)01705-2","article-title":"Use of an aromatase inhibitor for induction of ovulation in cases of inadequate response to clomiphene citrate.","volume":"75","author":"Mitwally","year":"2001","journal-title":"Fertil Steril"},{"key":"R24-19-20210126","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.rbmo.2009.06.008","article-title":"Aromatase inhibitors for female infertility: a systematic review of the literature.","volume":"19","author":"Polyzos","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"R26-19-20210126","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fertnstert.2005.01.117","article-title":"The AI letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study.","volume":"84","author":"Garcia-Velasco","year":"2005","journal-title":"Fertil Steril"},{"key":"R27-19-20210126","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.fertnstert.2004.04.070","article-title":"A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation.","volume":"82","author":"Al-Fozan","year":"2004","journal-title":"Fertil Steril"},{"key":"R28-19-20210126","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.fertnstert.2004.07.952","article-title":"Single-dose administration of an aromatase inhibitor for ovarian stimulation.","volume":"83","author":"Mitwally","year":"2005","journal-title":"Fertil Steril"},{"key":"R30-19-20210126","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1200\/JCO.2002.06.020","article-title":"American Society of Clinical Oncology Technology Assessment on the use of aromatase inhibitors as adjuvant therapy for women with hormone receptor-positive breast cancer: status report 2002.","volume":"2015","author":"Winer","year":"2002","journal-title":"J Clin Oncol"},{"key":"R31-19-20210126","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fertnstert.2005.01.117","article-title":"The AI letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study.","volume":"84","author":"Garcia-Velasco","year":"2005","journal-title":"Fertil Steril"},{"key":"R32-19-20210126","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ajog.2004.08.013","article-title":"Pregnancy outcome after the use of an AI for induction of ovulation.","volume":"192","author":"Mitwally","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 1","key":"R33-19-20210126","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.fertnstert.2005.07.230","article-title":"The outcome of 150 babies following the treatment with letrozole or letrozole and gonadotropins.","volume":"84","author":"Biljan","year":"2005","journal-title":"Fertil Steril"},{"key":"R36-19-20210126","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/humrep\/del273","article-title":"Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation.","volume":"21","author":"Bedaiwy","year":"2006","journal-title":"Hum Reprod"}],"container-title":["Clinical Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003081-201112000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:25:11Z","timestamp":1786047911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003081-201112000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/grf.0b013e3182353d0f","relation":{},"ISSN":["0009-9201"],"issn-type":[{"value":"0009-9201","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}