{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:44:02Z","timestamp":1778078642129,"version":"3.51.4"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/ http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Although high mortality is associated with liver cirrhosis, patients usually have a good quality of life in the compensated phase, and the disease may progress undiagnosed for many years. Vibration-controlled transient elastography with controlled attenuation parameter is a useful noninvasive tool used to estimate both the severity of fibrosis and steatosis. Hence, we aimed to establish the prevalence of significant liver fibrosis diagnosed by vibration-controlled transient elastography in an apparently healthy population. Between December 2021 and March 2022, we conducted a prospective screening of liver fibrosis in apparently healthy participants from different counties of Northeastern Romania. All subjects\u2019 medical history was recorded through a comprehensive questionnaire and underwent a liver stiffness measurement. Participants with abnormal liver stiffness measurement values were further evaluated by laboratory tests to identify the etiology of chronic liver disease. A total of 127 apparently healthy subjects were enrolled, mainly females (59.8%), with a mean age of 56\u00b111 years. Overall, 12.6% of participants were found to have significant to advanced fibrosis, and 5.4% had liver cirrhosis. Among 184 participants with clinically significant fibrosis (\u22658.0\u00a0kPa), 26.1% had a history of heavy alcohol intake, 22.3% tested positive for hepatitis B and C infection, and 2.1% with other etiologies. The remaining 49.5% participants with clinically significant fibrosis were diagnosed with NAFLD, with a mean controlled attenuation parameter value of 282\u00b134\u00a0dB\/m. The high prevalence of significant liver fibrosis in the general population of Romania is alarming and should raise awareness among clinicians and public health systems. Vibration-controlled transient elastography has demonstrated its usefulness as a screening tool to identify advanced liver fibrosis in general population and should be used in liver disease prevention strategies.<\/jats:p>","DOI":"10.1097\/hc9.0000000000000032","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T11:01:02Z","timestamp":1674558062000},"page":"e0032-e0032","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["High prevalence of liver fibrosis among general population: a Romanian population-based study"],"prefix":"10.1097","volume":"7","author":[{"given":"Anca","family":"Trifan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Grigore T. 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Popa University of Medicine and Pharmacy, Iasi, Romania"},{"name":"\u201cSt. Spiridon\u201d Emergency Hospital, Institute of Gastroenterology and Hepatology, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remus","family":"Stafie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania"},{"name":"\u201cSt. Spiridon\u201d Emergency Hospital, Institute of Gastroenterology and Hepatology, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Grigore T. 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