{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:37:21Z","timestamp":1788179841106,"version":"build-2803163510"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>To describe the relationship between three pandemics: hypertension, obesity, and heart failure. From pathophysiology to treatment, understanding how these disease entities are linked can lead to breakthroughs in their prevention and treatment. The relevance of this review lies in its discussion of novel pharmacological and surgical treatment strategies for obesity and hypertension, and their role in the prevention and treatment of heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>Novel medications such as GLP-1 agonists have demonstrated sustained weight loss in patients with obesity, and concurrent improvements in their cardiometabolic profile, and possibly also reductions in hypertension-related comorbidities including heart failure. Surgical therapies including laparoscopic bariatric surgery represent an important treatment strategy in obese patients, and recent studies describe their use even in patients with advanced heart failure, including those with ventricular assist devices.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>These developments have deep implications on our efforts to understand, mitigate, and ultimately prevent the three pandemics, and offer promising improvements to quality of life, survival, and the cost burden of these diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hco.0000000000001069","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:00:18Z","timestamp":1690797618000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Clinical considerations and pathophysiological associations among obesity, weight loss, heart failure, and hypertension"],"prefix":"10.1097","volume":"38","author":[{"given":"Maria Irene","family":"Barillas-Lara","sequence":"first","affiliation":[{"name":"Montefiore Department of Cardiovascular Disease, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Faaborg-Andersen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo A.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Section, Division of Cardiology, University of Colorado, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Loro-Ferrer","sequence":"additional","affiliation":[{"name":"Doctoral School, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy A.","family":"Mandras","sequence":"additional","affiliation":[{"name":"Transplant Institute, Orlando AdventHealth, Orlando, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"daSilva-deAbreu","sequence":"additional","affiliation":[{"name":"Doctoral School, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"},{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"R1-20250729","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N Engl J Med"},{"key":"R3-20250729","doi-asserted-by":"crossref","first-page":"028","DOI":"10.17352\/ach.000009","article-title":"Ambient air pollution and hypertension: a relationship that strikes around the clock","volume":"2","author":"Massimo","year":"2016","journal-title":"Arch Clin Hypertens"},{"key":"R5-20250729","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2105\/AJPH.2013.301379","article-title":"The impact of obesity on US mortality levels: the importance of age and cohort factors in population estimates","volume":"103","author":"Masters","year":"2013","journal-title":"Am J Public Health"},{"key":"R7-20250729","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"R8-20250729","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease: a scientific statement from the American Heart Association","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation"},{"key":"R9-20250729","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1093\/eurjpc\/zwac187","article-title":"Obesity and cardiovascular disease: mechanistic insights and management strategies. 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