{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:21Z","timestamp":1786118901967,"version":"build-2736575974"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1097\/hco.0b013e3282294d72","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T03:01:35Z","timestamp":1186455695000},"page":"443-449","source":"Crossref","is-referenced-by-count":31,"title":["Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure"],"prefix":"10.1097","volume":"22","author":[{"given":"Cinzia","family":"Perrino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A","family":"Rockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210204","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/415206a","article-title":"Seven-transmembrane-spanning receptors and heart function","volume":"415","author":"Rockman","year":"2002","journal-title":"Nature"},{"key":"R2-8-20210204","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1001\/jama.292.19.2350","article-title":"Prognostic significance of left ventricular mass change during treatment of hypertension","volume":"292","author":"Devereux","year":"2004","journal-title":"JAMA"},{"key":"R3-8-20210204","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/hc0102.101365","article-title":"Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress","volume":"105","author":"Esposito","year":"2002","journal-title":"Circulation"},{"key":"R4-8-20210204","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"R5-8-20210204","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm908","article-title":"Seven-transmembrane receptors","volume":"3","author":"Pierce","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R6-8-20210204","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ceb.2004.01.001","article-title":"beta-arrestins: traffic cops of cell signaling","volume":"16","author":"Lefkowitz","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"R8-8-20210204","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2006.01.018","article-title":"Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure","volume":"45","author":"Perrino","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"R9-8-20210204","doi-asserted-by":"crossref","first-page":"18953","DOI":"10.1074\/jbc.M102376200","article-title":"Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration","volume":"276","author":"Naga Prasad","year":"2001","journal-title":"J Biol Chem"},{"key":"R10-8-20210204","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.200202113","article-title":"Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor\/beta-arrestin complex","volume":"158","author":"Naga Prasad","year":"2002","journal-title":"J Cell Biol"},{"key":"R11-8-20210204","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ncb1278","article-title":"Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis","volume":"7","author":"Naga Prasad","year":"2005","journal-title":"Nat Cell Biol"},{"key":"R12-8-20210204","first-page":"E633","article-title":"Mechanisms involved in alpha-adrenergic phenomena","volume":"248","author":"Exton","year":"1985","journal-title":"Am J Physiol"},{"key":"R13-8-20210204","first-page":"1039","article-title":"Alpha-1 adrenergic receptors in the nonfailing and failing human heart","volume":"247","author":"Bristow","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"R14-8-20210204","doi-asserted-by":"crossref","first-page":"15374","DOI":"10.1016\/S0021-9258(18)82267-0","article-title":"The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy","volume":"268","author":"Knowlton","year":"1993","journal-title":"J Biol Chem"},{"key":"R15-8-20210204","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/hh1601.095912","article-title":"Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy","volume":"89","author":"Lin","year":"2001","journal-title":"Circ Res"},{"key":"R16-8-20210204","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1073\/pnas.94.15.8121","article-title":"Transgenic Galphaq overexpression induces cardiac contractile failure in mice","volume":"94","author":"D'Angelo","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-8-20210204","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodelling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R18-8-20210204","doi-asserted-by":"crossref","first-page":"21253","DOI":"10.1074\/jbc.272.34.21253","article-title":"Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signalling","volume":"272","author":"Akhter","year":"1997","journal-title":"J Biol Chem"},{"key":"R19-8-20210204","doi-asserted-by":"crossref","first-page":"H1079","DOI":"10.1152\/ajpheart.2000.279.3.H1079","article-title":"Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts","volume":"279","author":"Wang","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R20-8-20210204","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI22811","article-title":"Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload","volume":"116","author":"O'Connell","year":"2006","journal-title":"J Clin Invest"},{"key":"R21-8-20210204","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/CIRCULATIONAHA.106.664862","article-title":"An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes","volume":"115","author":"Huang","year":"2007","journal-title":"Circulation"},{"key":"R22-8-20210204","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1172\/JCI28234","article-title":"Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify","volume":"116","author":"Liggett","year":"2006","journal-title":"J Clin Invest"},{"key":"R23-8-20210204","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0735-1097(01)01121-4","article-title":"Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure","volume":"37","author":"Aggarwal","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"R24-8-20210204","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1124\/mol.56.1.154","article-title":"Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice","volume":"56","author":"Altman","year":"1999","journal-title":"Mol Pharmacol"},{"key":"R25-8-20210204","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1096\/fasebj.6.3.1346768","article-title":"Subtypes of alpha 1- and alpha 2-adrenergic receptors","volume":"6","author":"Bylund","year":"1992","journal-title":"FASEB J"},{"key":"R26-8-20210204","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.273.5276.803","article-title":"Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c","volume":"273","author":"Link","year":"1996","journal-title":"Science"},{"key":"R27-8-20210204","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/46040","article-title":"Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission","volume":"402","author":"Hein","year":"1999","journal-title":"Nature"},{"key":"R28-8-20210204","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/01.CIR.0000036600.39600.66","article-title":"Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure","volume":"106","author":"Brede","year":"2002","journal-title":"Circulation"},{"key":"R29-8-20210204","first-page":"143","article-title":"Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction","volume":"47","author":"Perrino","year":"2005","journal-title":"Panminerva Med"},{"key":"R30-8-20210204","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1073\/pnas.93.14.7375","article-title":"Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects","volume":"93","author":"Rohrer","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R31-8-20210204","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1073\/pnas.96.12.7059","article-title":"Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice","volume":"96","author":"Engelhardt","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R32-8-20210204","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.CIR.73.5.913","article-title":"Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure","volume":"73","author":"Leimbach","year":"1986","journal-title":"Circulation"},{"key":"R33-8-20210204","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tcm.2004.07.002","article-title":"Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts","volume":"14","author":"Tevaearai","year":"2004","journal-title":"Trends Cardiovasc Med"},{"key":"R34-8-20210204","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI18213","article-title":"Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure","volume":"112","author":"Nienaber","year":"2003","journal-title":"J Clin Invest"},{"key":"R35-8-20210204","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.jacc.2005.02.062","article-title":"Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression","volume":"45","author":"Perrino","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R36-8-20210204","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.104.508796","article-title":"Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1\/phosphoinositide 3-kinase complex","volume":"111","author":"Perrino","year":"2005","journal-title":"Circulation"},{"key":"R37-8-20210204","doi-asserted-by":"crossref","first-page":"H1754","DOI":"10.1152\/ajpheart.01199.2005","article-title":"Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling","volume":"291","author":"Curcio","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R38-8-20210204","first-page":"IV97","article-title":"Inodilator therapy for heart failure. Early, late, or not at all?","volume":"87","author":"Remme","year":"1993","journal-title":"Circulation"},{"key":"R39-8-20210204","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1161\/hc4701.099578","article-title":"beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure","volume":"104","author":"Reiken","year":"2001","journal-title":"Circulation"},{"key":"R40-8-20210204","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/01.CIR.0000068316.53218.49","article-title":"Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure","volume":"107","author":"Reiken","year":"2003","journal-title":"Circulation"},{"key":"R41-8-20210204","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ncpcardio0419","article-title":"Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia","volume":"3","author":"Yano","year":"2006","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"R42-8-20210204","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.CIR.79.3.483","article-title":"Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy","volume":"79","author":"Heilbrunn","year":"1989","journal-title":"Circulation"},{"key":"R43-8-20210204","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1006\/jmcc.2000.1123","article-title":"Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice","volume":"32","author":"Bisognano","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"R44-8-20210204","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.RES.78.4.517","article-title":"Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression","volume":"78","author":"Iwase","year":"1996","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"R45-8-20210204","doi-asserted-by":"crossref","first-page":"SI8","DOI":"10.1016\/S0140-6736(98)90311-7","article-title":"Why does the myocardium fail? Insights from basic science","volume":"352","author":"Bristow","year":"1998","journal-title":"Lancet"},{"key":"R46-8-20210204","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/01.RES.0000184615.56822.bd","article-title":"The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly","volume":"97","author":"Zhu","year":"2005","journal-title":"Circ Res"},{"key":"R47-8-20210204","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.8160017","article-title":"Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor","volume":"264","author":"Milano","year":"1994","journal-title":"Science"},{"key":"R48-8-20210204","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.101.14.1707","article-title":"Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level","volume":"101","author":"Liggett","year":"2000","journal-title":"Circulation"},{"key":"R49-8-20210204","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1172\/JCI113569","article-title":"Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart","volume":"82","author":"Feldman","year":"1988","journal-title":"J Clin Invest"},{"key":"R50-8-20210204","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.RES.0000181160.31851.05","article-title":"Crosstalk of beta-adrenergic receptor subtypes through Gi blunts beta-adrenergic stimulation of L-type Ca2+ channels in canine heart failure","volume":"97","author":"He","year":"2005","journal-title":"Circ Res"},{"key":"R51-8-20210204","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M506576200","article-title":"beta-arrestin-dependent, G protein-independent ERK1\/2 activation by the beta2 adrenergic receptor","volume":"281","author":"Shenoy","year":"2006","journal-title":"J Biol Chem"},{"key":"R52-8-20210204","first-page":"cm10","article-title":"Seven-transmembrane receptor signaling through beta-arrestin.","volume":"308","author":"Shenoy","year":"2005","journal-title":"Sci STKE"},{"key":"R53-8-20210204","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/01.HYP.0000232641.84521.92","article-title":"Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease","volume":"48","author":"Smith","year":"2006","journal-title":"Hypertension"},{"key":"R54-8-20210204","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","article-title":"EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF","volume":"402","author":"Prenzel","year":"1999","journal-title":"Nature"},{"key":"R55-8-20210204","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.pharmtox.37.1.421","article-title":"Structure and function of the beta 3-adrenergic receptor","volume":"37","author":"Strosberg","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R56-8-20210204","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1161\/hc4501.098933","article-title":"Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice","volume":"104","author":"Kohout","year":"2001","journal-title":"Circulation"},{"key":"R57-8-20210204","doi-asserted-by":"crossref","first-page":"29483","DOI":"10.1074\/jbc.270.49.29483","article-title":"Targeted disruption of the beta 3-adrenergic receptor gene","volume":"270","author":"Susulic","year":"1995","journal-title":"J Biol Chem"},{"key":"R58-8-20210204","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.CIR.103.12.1649","article-title":"Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium","volume":"103","author":"Moniotte","year":"2001","journal-title":"Circulation"},{"key":"R59-8-20210204","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","article-title":"Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy","volume":"100","author":"McMullen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R60-8-20210204","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1172\/JCI25397","article-title":"Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction","volume":"116","author":"Perrino","year":"2006","journal-title":"J Clin Invest"}],"container-title":["Current Opinion in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/HCO.0b013e3282294d72","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:52:48Z","timestamp":1786035168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001573-200709000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/hco.0b013e3282294d72","relation":{},"ISSN":["0268-4705"],"issn-type":[{"value":"0268-4705","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}