{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:49:55Z","timestamp":1782773395296,"version":"3.54.5"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1097\/hcr.0b013e3182a0299a","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T07:34:11Z","timestamp":1379403251000},"page":"263-273","source":"Crossref","is-referenced-by-count":34,"title":["Exercise Training and Rehabilitation in Pulmonary Arterial Hypertension"],"prefix":"10.1097","volume":"33","author":[{"given":"Barak","family":"Zafrir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20210128","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1183\/09059180.00003512","article-title":"A critical analysis of survival in pulmonary arterial hypertension.","volume":"21","author":"OCallaghan","year":"2012","journal-title":"Eur Respir Rev"},{"issue":"9129","key":"R2-1-20210128","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0140-6736(98)02111-4","article-title":"Primary pulmonary hypertension.","volume":"352","author":"Gaine","year":"1998","journal-title":"Lancet"},{"key":"R3-1-20210128","first-page":"7","article-title":"Exercise training for pulmonary hypertension: another prescription to write Eur Respir J.","volume":"40","author":"Rubin","year":"2012","journal-title":""},{"key":"R4-1-20210128","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/01.HCR.0000311502.57022.73","article-title":"Exercise in patients with pulmonary arterial hypertension.","volume":"28","author":"Desai","year":"2008","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"R5-1-20210128","first-page":"183","article-title":"Feasibility of cardiopulmonary rehabilitation in patients with idiopathic pulmonary arterial hypertension treated with intravenous prostacyclin infusion therapy.","volume":"46","author":"Uchi","year":"2005","journal-title":"J Cardiol"},{"key":"R6-1-20210128","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/CIRCULATIONAHA.106.618397","article-title":"Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension.","volume":"114","author":"Mereles","year":"2006","journal-title":"Circulation"},{"key":"R7-1-20210128","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1183\/09031936.00027909","article-title":"Effects of exercise training in patients with idiopathic pulmonary arterial hypertension.","volume":"34","author":"De Man","year":"2009","journal-title":"Eur Respir J"},{"key":"R8-1-20210128","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/HCR.0b013e3181d6f962","article-title":"Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension.","volume":"30","author":"Mainguy","year":"2010","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"R9-1-20210128","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cardfail.2010.10.004","article-title":"Ambulatory rehabilitation improves exercise capacity in patients with pulmonary hypertension.","volume":"17","author":"Fox","year":"2011","journal-title":"J Cardiac Fail"},{"key":"R10-1-20210128","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000322475","article-title":"Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension.","volume":"81","author":"Grunig","year":"2011","journal-title":"Respiration"},{"key":"R11-1-20210128","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1186\/ar3883","article-title":"Exercise training in pulmonary arterial hypertension associated with connective tissue diseases.","volume":"14","author":"Grunig","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"R12-1-20210128","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1183\/09031936.00123711","article-title":"Safety and efficacy of exercise training in various forms of pulmonary hypertension.","volume":"40","author":"Grunig","year":"2012","journal-title":"Eur Respir J"},{"key":"R13-1-20210128","doi-asserted-by":"crossref","first-page":"e41603","DOI":"10.1371\/journal.pone.0041603","article-title":"Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension.","volume":"7","author":"Nagel","year":"2012","journal-title":"PLoS One"},{"key":"R15-1-20210128","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1747-0803.2009.00370.x","article-title":"Rehabilitation program in adult congenital heart disease patients with pulmonary hypertension.","volume":"5","author":"Martinez-Quintana","year":"2010","journal-title":"Congenit Heart Dis"},{"key":"R16-1-20210128","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00330-012-2606-z","article-title":"Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension.","volume":"23","author":"Ley","year":"2013","journal-title":"Eur Radiol"},{"key":"R17-1-20210128","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1378\/chest.12-0993","article-title":"Benefits of intensive treadmill exercise training on cardiorespiratory function and quality of life in patients with pulmonary hypertension.","volume":"143","author":"Chan","year":"2013","journal-title":"Chest"},{"key":"R18-1-20210128","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2147\/JMDH.S26617","article-title":"Australian perspective regarding recommendations for physical activity and exercise rehabilitation in pulmonary arterial hypertension.","volume":"4","author":"Fowler","year":"2011","journal-title":"J Multidiscip Healthc"},{"key":"R19-1-20210128","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","article-title":"ACCFAHA 2009 expert consensus document on pulmonary hypertension.","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"R20-1-20210128","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pcad.2012.07.003","article-title":"Exercise physiology and pulmonary arterial hypertension.","volume":"55","author":"Waxman","year":"2012","journal-title":"Prog Cardiovasc Dis"},{"key":"R21-1-20210128","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1183\/09031936.06.00130405","article-title":"Measurement of quality of life in pulmonary hypertension and its significance.","volume":"28","author":"Cenedese","year":"2006","journal-title":"Eur Respir J"},{"key":"R22-1-20210128","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.healun.2007.10.004","article-title":"United States validation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR).","volume":"27","author":"Gomberg-Maitland","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"suppl 165","key":"R23-1-20210128","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1742-1241.2009.02231.x","article-title":"Exercise as an end-point in pulmonary hypertension trials.","volume":"64","author":"McCullagh","year":"2010","journal-title":"Int J Clin Pract"},{"key":"R24-1-20210128","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1164\/ajrccm.161.2.9906015","article-title":"Clinical correlates and prognostic significance of Six-Minute Walk Test in patients with cardiopulmonary exercise testing.","volume":"161","author":"Miyamoto","year":"2000","journal-title":"Am J Crit Care Med"},{"key":"R25-1-20210128","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/CIRCHEARTFAILURE.108.807826","article-title":"Value of exercise treadmill testing in the risk stratification of patients with pulmonary hypertension.","volume":"2","author":"Shah","year":"2009","journal-title":"Circ Heart Fail"},{"key":"R26-1-20210128","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1183\/09031936.06.00042705","article-title":"Heart rate responses during the 6-Minute Walk Test in pulmonary arterial hypertension.","volume":"27","author":"Provencher","year":"2006","journal-title":"Eur Respir J"},{"key":"R27-1-20210128","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ahj.2012.01.023","article-title":"Heart rate recovery in pulmonary arterial hypertension: relationship with exercise capacity and prognosis.","volume":"163","author":"Ramos","year":"2012","journal-title":"Am Heart J"},{"key":"R28-1-20210128","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1164\/rccm.201105-0848OC","article-title":"Heart rate recovery predicts clinical worsening in patients with pulmonary arterial hypertension.","volume":"185","author":"Minai","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"R29-1-20210128","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.healun.2009.09.003","article-title":"Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: an evidence-based review.","volume":"29","author":"Arena","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"R30-1-20210128","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1378\/chest.127.5.1637","article-title":"End-tidal PCO2 abnormality and exercise limitation in patients with primary pulmonary hypertension.","volume":"127","author":"Yasunobu","year":"2005","journal-title":"Chest"},{"key":"R31-1-20210128","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.pcad.2011.02.003","article-title":"Exercise testing and training in chronic lung disease and pulmonary arterial hypertension.","volume":"53","author":"Arena","year":"2011","journal-title":"Prog Cardiovasc Dis"},{"key":"R32-1-20210128","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/hc2901.093198","article-title":"Exercise pathophysiology in patients with primary pulmonary hypertension.","volume":"104","author":"Sun","year":"2001","journal-title":"Circulation"},{"key":"R33-1-20210128","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.healun.2009.07.005","article-title":"Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension.","volume":"29","author":"Chandra","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"R34-1-20210128","doi-asserted-by":"crossref","first-page":"359204","DOI":"10.1155\/2012\/359204","article-title":"Exercise intolerance in pulmonary arterial hypertension.","volume":"2012","author":"Fowler","year":"2012","journal-title":"Pulm Med"},{"key":"R35-1-20210128","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.rmed.2008.06.014","article-title":"Peripheral endothelial dysfunction in patients with pulmonary arterial hypertension.","volume":"102","author":"Peled","year":"2008","journal-title":"Respir Med"},{"key":"R36-1-20210128","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/thx.2009.117168","article-title":"Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension.","volume":"65","author":"Mainguy","year":"2010","journal-title":"Thorax"},{"key":"R37-1-20210128","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.rmed.2007.06.014","article-title":"Skeletal muscle dysfunction in patients with idiopathic pulmonary arterial hypertension.","volume":"101","author":"Bauer","year":"2007","journal-title":"Respir Med"},{"key":"R38-1-20210128","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pcad.2012.07.006","article-title":"Immune and inflammatory mechanisms in pulmonary arterial hypertension.","volume":"55","author":"El Chami","year":"2012","journal-title":"Prog Cardiovasc Dis"},{"key":"R39-1-20210128","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0735-1097(03)00848-9","article-title":"Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure.","volume":"42","author":"Gielen","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R40-1-20210128","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1183\/09031936.04.00095804","article-title":"Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension.","volume":"25","author":"Meyer","year":"2005","journal-title":"Eur Respir J"},{"key":"R41-1-20210128","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/CS20070238","article-title":"Impairment of respiratory muscle function in pulmonary hypertension.","volume":"114","author":"Kabitz","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"R42-1-20210128","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/1741826711410516","article-title":"Effect of outpatient exercise training programmes in patients with chronic heart failure: a systematic review.","volume":"19","author":"van der Meer","year":"2012","journal-title":"Eur J Prev Cardiol"},{"key":"R43-1-20210128","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/eurjhf\/hfq056","article-title":"Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis.","volume":"12","author":"Davies","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"R44-1-20210128","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bmj.328.7441.711-b","article-title":"Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH).","volume":"328","author":"Piepoli","year":"2004","journal-title":"BMJ"},{"key":"R45-1-20210128","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1056\/NEJMra0800239","article-title":"Biomarkers in heart failure.","volume":"358","author":"Braunwald","year":"2008","journal-title":"N Engl J Med"},{"key":"R46-1-20210128","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/clc.20317","article-title":"Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients.","volume":"32","author":"Amir","year":"2009","journal-title":"Clin Cardiol"},{"key":"R47-1-20210128","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000324192","article-title":"Increased serum levels of oxidative stress are associated with hospital readmissions due to acute heart failure.","volume":"118","author":"Rogowski","year":"2011","journal-title":"Cardiology"},{"key":"R48-1-20210128","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.cardfail.2012.10.013","article-title":"Absence of the (2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure.","volume":"18","author":"Amir","year":"2012","journal-title":"J Card Fail"},{"key":"R49-1-20210128","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jacc.2011.04.020","article-title":"The role of exercise training in heart failure.","volume":"58","author":"Downing","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"R50-1-20210128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10741-007-9051-0","article-title":"Principles of exercise prescription for patients with chronic heart failure.","volume":"13","author":"Myers","year":"2008","journal-title":"Heart Fail Rev"},{"key":"R51-1-20210128","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.2009.454","article-title":"Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.","volume":"301","author":"OConnor","year":"2009","journal-title":"JAMA"},{"key":"R52-1-20210128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10741-007-9052-z","article-title":"Exercise training in patients with heart failure: clinical outcomes, safety, and indications.","volume":"13","author":"McKelvie","year":"2008","journal-title":"Heart Fail Rev"},{"key":"R53-1-20210128","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10741-007-9055-9","article-title":"Resistance exercise: training adaptations and developing a safe exercise prescription.","volume":"13","author":"Braith","year":"2008","journal-title":"Heart Fail Rev"},{"issue":"10","key":"R54-1-20210128","first-page":"CD005305","article-title":"Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease.","author":"Puhan","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"R55-1-20210128","first-page":"475","article-title":"Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. A Cochrane systematic review.","volume":"43","author":"Lacasse","year":"2007","journal-title":"Eura Medicophys"},{"key":"R56-1-20210128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/rccm.200408-1109SO","article-title":"Pulmonary rehabilitation in chronic obstructive pulmonary disease.","volume":"172","author":"Troosters","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R57-1-20210128","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/01.psy.0000145593.37594.39","article-title":"Anxiety and depression in patients with pulmonary hypertension.","volume":"66","author":"Lowe","year":"2004","journal-title":"Psychosom Med"},{"key":"R58-1-20210128","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.amjcard.2012.06.021","article-title":"Meta-analysis of the effect of cardiac rehabilitation interventions on depression outcomes in adults 64 years of age and older.","volume":"110","author":"Gellis","year":"2012","journal-title":"Am J Cardiol"},{"key":"R59-1-20210128","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3810\/pgm.2012.05.2553","article-title":"Depression in patients with chronic obstructive pulmonary disease.","volume":"124","author":"Garvey","year":"2012","journal-title":"Postgrad Med"},{"key":"R60-1-20210128","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF01047288","article-title":"Effects of physical training on pulmonary arterial pressure during exercise under hypobaric hypoxia in rats.","volume":"35","author":"Kashimura","year":"1991","journal-title":"Int J Biometeorol"},{"key":"R61-1-20210128","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1152\/japplphysiol.00673.2005","article-title":"Exercise training improves lung gas exchange and attenuates acute hypoxic pulmonary hypertension but does not prevent pulmonary hypertension of prolonged hypoxia.","volume":"100","author":"Favret","year":"2006","journal-title":"J Appl Physiol"},{"key":"R62-1-20210128","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2007.11.037","article-title":"Acute administration of P-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats.","volume":"581","author":"Goret","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"R63-1-20210128","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/CIRCULATIONAHA.108.829713","article-title":"Opposite effects of training in rats with stable and progressive pulmonary hypertension.","volume":"120","author":"Handoko","year":"2009","journal-title":"Circulation"},{"key":"R64-1-20210128","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1139\/cjpp-2012-0261","article-title":"Effects of exercise on monocrotaline-induced changes in right heart function and pulmonary artery remodeling in rats.","volume":"91","author":"Colombo","year":"2013","journal-title":"Can J Physiol Pharmacol"}],"container-title":["Journal of Cardiopulmonary Rehabilitation and Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/HCR.0b013e3182a0299a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T01:02:01Z","timestamp":1620954121000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01273116-201309000-00001"}},"subtitle":["RATIONALE AND CURRENT DATA EVALUATION"],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/hcr.0b013e3182a0299a","relation":{},"ISSN":["1932-7501"],"issn-type":[{"value":"1932-7501","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}