{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:30:20Z","timestamp":1789648220222,"version":"4.0.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims:<\/jats:title>\n            <jats:p>Baveno VII consensus suggests that screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is \u226440\u00a0kPa as they have a low probability of high-risk varices (HRV). Conversely, screening endoscopy is required in all patients with porto-sinusoidal vascular disorder (PSVD). This study aimed to evaluate the performance of SSM-VCTE to rule out HRV in patients with PSVD and signs of portal hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>We retrospectively included patients with PSVD, \u22651 sign of portal hypertension, without a history of variceal bleeding, who underwent an SSM-VCTE within 2 years before or after an upper endoscopy in 21 VALDIG centers, divided into a derivation and a validation cohort. One hundred fifty-four patients were included in the derivation cohort; 43% had HRV. By multivariable logistic regression analysis, SSM-VCTE &gt;40\u00a0kPa and serum bilirubin \u22651\u00a0mg\/dL were associated with HRV. SSM-VCTE \u226440\u00a0kPa combined with bilirubin &lt;1\u00a0mg\/dL had a sensitivity of 96% to rule out HRV and could spare 38% of screening endoscopies, with 4% of HRV missed, and a 95% negative predictive value. In the validation cohort, including 155 patients, SSM combined with bilirubin could spare 21% of screening endoscopies, with 4% of HRV missed and a 94% negative predictive value.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>This study gathering a total of 309 patients with PSVD showed that SSM-VCTE \u226440\u00a0kPa combined with bilirubin &lt;1\u00a0mg\/dL identifies patients with PSVD and portal hypertension with a probability of HRV &lt;5%, in whom screening endoscopy can be spared.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hep.0000000000001004","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T21:00:42Z","timestamp":1719954042000},"page":"546-559","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Performance of spleen stiffness measurement to rule out high-risk varices in patients with porto-sinusoidal vascular disorder"],"prefix":"10.1097","volume":"81","author":[{"given":"Lucile","family":"Moga","sequence":"first","affiliation":[{"name":"Service d\u2019H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France"},{"name":"Centre de recherche sur l\u2019inflammation,Universit\u00e9 Paris-Cit\u00e9, Inserm, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Paradis","sequence":"additional","affiliation":[{"name":"Centre de recherche sur l\u2019inflammation,Universit\u00e9 Paris-Cit\u00e9, Inserm, Paris, France"},{"name":"D\u00e9partement d\u2019Anatomie Pathologique, H\u00f4pital Beaujon, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ferreira-Silva","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushik","family":"Gudavalli","sequence":"additional","affiliation":[{"name":"Hepatology and Transplantation Unit, Department of Gastroenterology, Amrita Institute of Medical Sciences, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Indulti","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, CHIMOMO Department, University Hospital of Modena, University of Modena & Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elton","family":"Dajti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Nicoara-Farcau","sequence":"additional","affiliation":[{"name":"Department of Hepatology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 3rd Medical Clinic and Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d, Cluj-Napoca, Romania"},{"name":"Hepatic Hemodynamic Department, Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Tosetti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Antonenko","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Hepatology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 3rd Medical Clinic and Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Vidal-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Liver Unit, Digestive Diseases Department, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Research (VHIR), Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, CIBERehd, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Turco","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit for the Treatment of Severe Organ Failure, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Capinha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Gastrenterologia e Hepatologia, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Elkrief","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastro-Ent\u00e9rologie, CHRU de Tours-H\u00f4pital Trousseau, Facult\u00e9 de M\u00e9decine de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Monllor-Nunell","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitari Parc Taul\u00ed, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Sabadell, 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Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Poujol-Robert","sequence":"additional","affiliation":[{"name":"Department of H\u00e9patologie, H\u00f4pital Saint-Antoine-Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Thabut","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, H\u00f4pital Piti\u00e9 Salp\u00eatrie\u0300re-Assistance Publique-H\u00f4pitaux de Paris, Liver Intensive Care Unit, Paris, France"},{"name":"Centre de recherche Saint-Antoine, Inserm, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Houssel-Debry","sequence":"additional","affiliation":[{"name":"H\u00f4pital Pontchaillou-CHU de Rennes, Centre h\u00e9pato-digestif-Maladies du foie, Rennes, 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Amrita Institute of Medical Sciences, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Payanc\u00e9","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France"},{"name":"Centre de recherche sur l\u2019inflammation,Universit\u00e9 Paris-Cit\u00e9, Inserm, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Castera","sequence":"additional","affiliation":[{"name":"Centre de recherche sur l\u2019inflammation,Universit\u00e9 Paris-Cit\u00e9, Inserm, Paris, France"},{"name":"Service d\u2019H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, 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