{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:01:08Z","timestamp":1786118468847,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1097\/hjh.0b013e32801092c1","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T04:02:34Z","timestamp":1164859354000},"page":"141-146","source":"Crossref","is-referenced-by-count":78,"title":["The incremental effect of obstructive sleep apnoea syndrome on arterial stiffness in newly diagnosed essential hypertensive subjects"],"prefix":"10.1097","volume":"25","author":[{"given":"Costas","family":"Tsioufis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Thomopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Amfilochiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Tousoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manos","family":"Alchanatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christodoulos","family":"Stefanadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kallikazaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20210208","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","article-title":"Association of sleep disordered breathing, sleep apnea, and hypertension in a large community-based study","volume":"283","author":"Nieto","year":"2000","journal-title":"JAMA"},{"key":"R2-21-20210208","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N Engl J Med"},{"key":"R3-21-20210208","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure.","volume":"289","year":"2003","journal-title":"JAMA"},{"key":"R4-21-20210208","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1152\/jappl.2000.89.2.493","article-title":"Increased vasoconstrictor sensitivity in obstructive sleep apnea","volume":"89","author":"Kraiczi","year":"2000","journal-title":"J Appl Physiol"},{"key":"R5-21-20210208","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.CIR.0000105767.94169.E3","article-title":"Arterial stiffness, wave reflections and the risk of coronary artery disease","volume":"109","author":"Weber","year":"2004","journal-title":"Circulation"},{"key":"R6-21-20210208","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.99.18.2434","article-title":"Impact of aortic stiffness on survival in end organ renal disease","volume":"99","author":"Blacher","year":"1999","journal-title":"Circulation"},{"key":"R7-21-20210208","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.HYP.33.5.1111","article-title":"Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients","volume":"33","author":"Blacher","year":"1999","journal-title":"Hypertension"},{"key":"R8-21-20210208","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/01.HYP.37.5.1236","article-title":"Aortic stiffness is an independent predictor of all cause cardiovascular mortality in hypertensive patients","volume":"37","author":"Laurent","year":"2001","journal-title":"Hypertension"},{"key":"R9-21-20210208","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep related breathing disorders in adults.","volume":"22","year":"1999","journal-title":"Sleep"},{"key":"R10-21-20210208","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/00004872-200306000-00001","article-title":"2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension.","volume":"21","year":"2003","journal-title":"J Hypertens"},{"key":"R11-21-20210208","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1378\/chest.117.5.1417","article-title":"Sleep apnea and hypertension","volume":"117","author":"Garcia-Rio","year":"2000","journal-title":"Chest"},{"key":"R12-21-20210208","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/sleep\/21.7.749","article-title":"Reliability of scoring respiratory disturbance indexes and sleep staging","volume":"21","author":"Whitney","year":"1998","journal-title":"Sleep"},{"key":"R13-21-20210208","first-page":"I280","article-title":"Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography","volume":"84","author":"Schiller","year":"1991","journal-title":"Circulation"},{"key":"R14-21-20210208","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"American Society of Echocardiography Committee on Standards. Subcommittee on Quantication of Two-dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"issue":"Suppl. 3","key":"R15-21-20210208","first-page":"S9","article-title":"Reversion of arterial abnormalities by long term antihypertensive therapy in a large population. The Complior study","volume":"17","author":"Asmar","year":"1999","journal-title":"J Hypertens"},{"key":"R16-21-20210208","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1097\/01.hjh.0000174394.57644.69","article-title":"Left ventricular diastolic dysfunction is accompanied by increased aortic stiffness in the early stages of essential hypertension: a TDI approach","volume":"23","author":"Tsioufis","year":"2005","journal-title":"J Hypertens"},{"key":"R17-21-20210208","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.HYP.26.3.485","article-title":"Assessment of arterial distensibility by automatic pulse wave velocity measurement","volume":"26","author":"Asmar","year":"1995","journal-title":"Hypertension"},{"key":"R18-21-20210208","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1161\/01.CIR.0000069826.36125.B4","article-title":"Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases","volume":"107","author":"Safar","year":"2003","journal-title":"Circulation"},{"key":"R19-21-20210208","doi-asserted-by":"crossref","first-page":"c106","DOI":"10.1159\/000069546","article-title":"Microalbuminuria is closely related to impaired arterial elasticity in untreated patients with essential hypertension","volume":"93","author":"Tsioufis","year":"2003","journal-title":"Nephron Clin Pract"},{"key":"R20-21-20210208","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.ATV.0000060460.52916.D6","article-title":"Non-invasive assessment of arterial stiffness and risk of atherosclerotic events","volume":"23","author":"Oliver","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R21-21-20210208","first-page":"850","article-title":"Arterial stiffness increases during obstructive sleep apneas","volume":"25","author":"Jelic","year":"2002","journal-title":"Sleep"},{"key":"R22-21-20210208","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1172\/JCI118235","article-title":"Sympathetic neural mechanisms in obstructive sleep apnea","volume":"96","author":"Somers","year":"1995","journal-title":"J Clin Invest"},{"key":"R23-21-20210208","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1378\/chest.103.6.1763","article-title":"Augmented resting sympathetic activity in awake patients with obstructive sleep apnea","volume":"103","author":"Carlson","year":"1993","journal-title":"Chest"},{"key":"R24-21-20210208","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1097\/00004872-199715120-00063","article-title":"Autonomic cardiac regulation in obstructive sleep apnea syndrome: evidence from spontaneous baroreflex analysis during sleep","volume":"15","author":"Parati","year":"1997","journal-title":"J Hypertens"},{"key":"R25-21-20210208","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.32.6.1039","article-title":"Baroreflex control of sympathetic activity and heart rate in obstructive sleep apnea","volume":"32","author":"Narkiewitz","year":"1998","journal-title":"Hypertension"},{"key":"R26-21-20210208","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0895-7061(03)01033-1","article-title":"Carotid sinus stimulation responses are related with arterial elastic properties in hypertensive subjects","volume":"16","author":"Tsioufis","year":"2003","journal-title":"Am J Hypertens"},{"key":"R27-21-20210208","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1161\/01.CIR.102.21.2607","article-title":"Impairment of endothelium-dependent vasodilatation of resistance vessels in patients with obstructive sleep apnea.","volume":"102","author":"Kato","year":"2000","journal-title":"Circulation"},{"issue":"8 Suppl.","key":"R28-21-20210208","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1093\/sleep\/16.suppl_8.S15","article-title":"Possible atherogenic effect of hypoxia during obstructive sleep apnea","volume":"16","author":"Dean","year":"1993","journal-title":"Sleep"},{"key":"R29-21-20210208","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/ajrccm.161.1.9810062","article-title":"Vascular reactivity in obstructive sleep apnea syndrome","volume":"161","author":"Duchna","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R30-21-20210208","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1161\/01.CIR.0000018948.95175.03","article-title":"Elevated C-reactive protein in patients with obstructive sleep apnea","volume":"105","author":"Shamsuzzaman","year":"2002","journal-title":"Circulation"},{"key":"R31-21-20210208","first-page":"S2044","article-title":"Obstructive sleep apnea is associated with increased levels of inflammatory markers in untreated newly diagnosed essential hypertensive subjects","volume":"110","author":"Thomopoulos","year":"2004","journal-title":"Circulation"},{"key":"R32-21-20210208","first-page":"167","article-title":"On the origin of cardiovascular complications of sleep apnea syndrome by means of molecular interactions","volume":"104","author":"Jurkovicova","year":"2003","journal-title":"Bratisl Lek Listy"},{"key":"R33-21-20210208","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.HYP.34.2.309","article-title":"Renin activity and blood pressure in response to chronic episodic hypoxia","volume":"34","author":"Fletcher","year":"1999","journal-title":"Hypertension"},{"key":"R34-21-20210208","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1152\/japplphysiol.00152.2001","article-title":"Blood pressure response to chronic episodic hypoxia: the renin\u2013angiotensin system","volume":"92","author":"Fletcher","year":"2002","journal-title":"J Appl Physiol"},{"key":"R35-21-20210208","first-page":"217","article-title":"Peculiarities of nocturnal oxygen saturation in obstructive sleep apnea","volume":"41","author":"Miliauskas","year":"2005","journal-title":"Medicina (Kaunas)"},{"key":"R36-21-20210208","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.sleep.2004.03.004","article-title":"A stepped approach for prediction of obstructive sleep apnea in overtly asymptomatic obese subjects: a hospital based study","volume":"5","author":"Sharma","year":"2004","journal-title":"Sleep Med"},{"key":"R37-21-20210208","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0140-6736(04)16451-9","article-title":"Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial","volume":"363","author":"Julius","year":"2004","journal-title":"Lancet"},{"key":"R38-21-20210208","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.HYP.0000047464.66901.60","article-title":"Effect of smoking on arterial stiffness and pulse pressure amplification","volume":"41","author":"Mahmud","year":"2003","journal-title":"Hypertension"},{"key":"R39-21-20210208","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1001\/archinte.1994.00420190121014","article-title":"Smoking as a risk factor for sleep-disordered breathing","volume":"154","author":"Wetter","year":"1994","journal-title":"Arch Intern Med"},{"key":"R40-21-20210208","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","article-title":"Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study.","volume":"113","year":"2006","journal-title":"Circulation"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004872-200701000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:57:54Z","timestamp":1786031874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004872-200701000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e32801092c1","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}