{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T02:22:39Z","timestamp":1786587759818,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1097\/hjh.0b013e3282fd9949","type":"journal-article","created":{"date-parts":[[2008,5,5]],"date-time":"2008-05-05T03:21:16Z","timestamp":1209957676000},"page":"1181-1187","source":"Crossref","is-referenced-by-count":35,"title":["Increased low-grade inflammation and plasminogen-activator inhibitor-1 level in nondippers with sleep apnea syndrome"],"prefix":"10.1097","volume":"26","author":[{"given":"Joji","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hoshide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizukiyo","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210208","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/rccm.200503-340OC","article-title":"Early signs of atherosclerosis in obstructive sleep apnea","volume":"172","author":"Drager","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R2-18-20210208","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","article-title":"Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study","volume":"283","author":"Nieto","year":"2000","journal-title":"JAMA"},{"key":"R3-18-20210208","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N Engl J Med"},{"key":"R4-18-20210208","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N Engl J Med"},{"key":"R5-18-20210208","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"R6-18-20210208","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa041832","article-title":"Day\u2013night pattern of sudden death in obstructive sleep apnea","volume":"352","author":"Gami","year":"2005","journal-title":"N Engl J Med"},{"key":"R7-18-20210208","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/00004872-199715110-00006","article-title":"Undiagnosed sleep-disordered breathing among male nondippers with essential hypertension","volume":"15","author":"Portaluppi","year":"1997","journal-title":"J Hypertens"},{"key":"R8-18-20210208","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/sleep\/22.7.849","article-title":"Nasal continuous positive airway pressure changes blood pressure \u2018nondippers\u2019 to \u2018dippers\u2019 in patients with obstructive sleep apnea","volume":"22","author":"Akashiba","year":"1999","journal-title":"Sleep"},{"key":"R9-18-20210208","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0895-7061(03)00567-3","article-title":"Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives","volume":"16","author":"Hoshide","year":"2003","journal-title":"Am J Hypertens"},{"key":"R10-18-20210208","first-page":"875","article-title":"Diurnal blood pressure variations and silent cerebrovascular damage in elderly patients with hypertension","volume":"10","author":"Shimada","year":"1992","journal-title":"J Hypertens"},{"key":"R11-18-20210208","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/00004872-200211000-00017","article-title":"Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: The Ohasama Study","volume":"20","author":"Ohkubo","year":"2002","journal-title":"J Hypertens"},{"key":"R12-18-20210208","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis: an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"R13-18-20210208","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.STR.0000258115.46765.f1","article-title":"Low-grade inflammation is a risk factor for clinical stroke events in addition to silent cerebral infarcts in Japanese older hypertensives. The Jichi Medical School ABPM study, wave 1","volume":"38","author":"Ishikawa","year":"2007","journal-title":"Stroke"},{"key":"R14-18-20210208","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa021993","article-title":"Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events","volume":"347","author":"Ridker","year":"2002","journal-title":"N Engl J Med"},{"key":"R15-18-20210208","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1161\/01.CIR.0000161819.76138.5E","article-title":"Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration","volume":"111","author":"Larkin","year":"2005","journal-title":"Circulation"},{"key":"R16-18-20210208","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1161\/01.CIR.0000018948.95175.03","article-title":"Elevated c-reactive protein in patients with obstructive sleep apnea","volume":"105","author":"Shamsuzzaman","year":"2002","journal-title":"Circulation"},{"key":"R17-18-20210208","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.21.4.611","article-title":"Prospective study of fibrinolytic factors and incident coronary heart disease: the atherosclerosis risk in communities (ARIC) study","volume":"21","author":"Folsom","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R18-18-20210208","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1161\/01.ATV.20.4.1155","article-title":"Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells","volume":"20","author":"Uchiyama","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R19-18-20210208","article-title":"A manual of standardized terminology and scoring system for sleep stages of human subjects","author":"Rechtschaffen","year":"1968"},{"key":"R20-18-20210208","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/sleep\/15.2.173","article-title":"EEG arousals: Scoring rules and examples: A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association.","volume":"15","year":"1992","journal-title":"Sleep"},{"key":"R21-18-20210208","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med"},{"key":"R22-18-20210208","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1097\/00004872-200208000-00011","article-title":"The majority of nondipping men do not have increased cardiovascular risk: a population-based study","volume":"20","author":"Bjorklund","year":"2002","journal-title":"J Hypertens"},{"key":"R23-18-20210208","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.HYP.0000258215.26755.20","article-title":"Ambulatory blood pressure and cardiovascular outcome in relation to perceived sleep deprivation","volume":"49","author":"Verdecchia","year":"2007","journal-title":"Hypertension"},{"key":"R24-18-20210208","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0895-7061(02)03267-3","article-title":"Abnormal vasoactive hormones and 24-h blood pressure in obstructive sleep apnea","volume":"16","author":"Moller","year":"2003","journal-title":"Am J Hypertens"},{"key":"R25-18-20210208","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1378\/chest.125.1.112","article-title":"Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea","volume":"125","author":"Calhoun","year":"2004","journal-title":"Chest"},{"key":"R26-18-20210208","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/01.CIR.98.8.772","article-title":"Sympathetic activity in obese subjects with and without obstructive sleep apnea","volume":"98","author":"Narkiewicz","year":"1998","journal-title":"Circulation"},{"key":"R27-18-20210208","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1164\/rccm.200306-767OC","article-title":"Endothelial function in obstructive sleep apnea and response to treatment","volume":"169","author":"Ip","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"R28-18-20210208","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.HYP.0000153794.52852.04","article-title":"Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension","volume":"45","author":"Allahdadi","year":"2005","journal-title":"Hypertension"},{"key":"R29-18-20210208","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1378\/chest.127.5.1674","article-title":"Oxidative stress in obstructive sleep apnea","volume":"127","author":"Yamauchi","year":"2005","journal-title":"Chest"},{"key":"R30-18-20210208","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/01.HYP.0000226046.58883.32","article-title":"Valsartan, blood pressure reduction, and C-reactive protein: primary report of the val-marc trial","volume":"48","author":"Ridker","year":"2006","journal-title":"Hypertension"},{"key":"R31-18-20210208","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.metabol.2006.03.011","article-title":"High serum high-sensitivity C-reactive protein concentrations are associated with relative cardiac sympathetic overactivity during the early morning period in type 2 diabetic patients with metabolic syndrome","volume":"55","author":"Aso","year":"2006","journal-title":"Metabolism"},{"key":"R32-18-20210208","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/HJH.0b013e3280112d0e","article-title":"C-reactive protein and intercellular adhesion molecule-1 are stronger predictors of oxidant stress than blood pressure in established hypertension","volume":"25","author":"Cottone","year":"2007","journal-title":"J Hypertens"},{"key":"R33-18-20210208","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.amjcard.2006.05.027","article-title":"Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome","volume":"98","author":"Wang","year":"2006","journal-title":"Am J Cardiol"},{"key":"R34-18-20210208","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.CIR.0000052627.99976.18","article-title":"Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure","volume":"107","author":"Yokoe","year":"2003","journal-title":"Circulation"},{"key":"R35-18-20210208","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.HYP.0000217128.41284.78","article-title":"Effects of continuous positive airway pressure versus supplemental oxygen on 24-h ambulatory blood pressure","volume":"47","author":"Norman","year":"2006","journal-title":"Hypertension"},{"key":"R36-18-20210208","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1161\/01.ATV.0000242905.41404.68","article-title":"PAI-1 and the metabolic syndrome: links, causes, and consequences","volume":"26","author":"Alessi","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R37-18-20210208","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI307","article-title":"Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition","volume":"102","author":"Pinsky","year":"1998","journal-title":"J Clin Invest"},{"key":"R38-18-20210208","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1161\/01.ATV.19.9.2029","article-title":"Hypoxia\/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis","volume":"19","author":"Yan","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R39-18-20210208","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1378\/chest.06-2006","article-title":"Association between polysomnographic measures of disrupted sleep and prothrombotic factors","volume":"131","author":"von Kanel","year":"2007","journal-title":"Chest"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/HJH.0b013e3282fd9949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:01:31Z","timestamp":1786035691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004872-200806000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e3282fd9949","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}