{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:39:16Z","timestamp":1768977556066,"version":"3.49.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1097\/hjh.0b013e328300a232","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T07:12:50Z","timestamp":1212995570000},"page":"1453-1462","source":"Crossref","is-referenced-by-count":36,"title":["Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions"],"prefix":"10.1097","volume":"26","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shimosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyo","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayoko","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzaburo","family":"Uetake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsu","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-28-20210208","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pcad.2006.02.001","article-title":"From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease","volume":"48","author":"Gradman","year":"2006","journal-title":"Prog Cardiovasc Dis"},{"key":"R2-28-20210208","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1056\/NEJMcp022709","article-title":"Diastolic heart failure","volume":"351","author":"Aurigemma","year":"2004","journal-title":"N Engl J Med"},{"key":"R3-28-20210208","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2004.12.096","article-title":"Progression of preserved systolic function heart failure to systolic dysfunction: a natural history study","volume":"106","author":"Cahill","year":"2006","journal-title":"Int J Cardiol"},{"key":"R4-28-20210208","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"R5-28-20210208","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone Post\u2013Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"R6-28-20210208","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/01.RES.86.4.463","article-title":"Coronary microvascular endothelial cell redox state in left ventricular hypertrophy","volume":"86","author":"Lang","year":"2000","journal-title":"Circ Res"},{"key":"R7-28-20210208","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"R8-28-20210208","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1161\/hc4901.100382","article-title":"Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase","volume":"104","author":"MacCarthy","year":"2001","journal-title":"Circulation"},{"key":"R9-28-20210208","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R10-28-20210208","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mce.2003.10.021","article-title":"Mineralocorticoid receptor binding, structure and function","volume":"217","author":"Rogerson","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"R11-28-20210208","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1046\/j.1523-1755.1999.00674.x","article-title":"Aldosterone activates Na+\/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms","volume":"56","author":"Ebata","year":"1999","journal-title":"Kidney Int"},{"key":"R12-28-20210208","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/01.HYP.0000056769.73726.E5","article-title":"Na\/H exchange isoform 1 is involved in mineralocorticoid\/salt-induced cardiac injury","volume":"41","author":"Fujisawa","year":"2003","journal-title":"Hypertension"},{"key":"R13-28-20210208","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.HYP.0000102863.23854.0B","article-title":"Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes","volume":"42","author":"Karmazyn","year":"2003","journal-title":"Hypertension"},{"key":"R14-28-20210208","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1210\/en.2005-1244","article-title":"Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium","volume":"147","author":"Yamamuro","year":"2006","journal-title":"Endocrinology"},{"key":"R15-28-20210208","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0024-3205(03)00315-1","article-title":"Contribution of salt intake to insulin resistance associated with hypertension","volume":"73","author":"Ogihara","year":"2003","journal-title":"Life Sci"},{"key":"R16-28-20210208","doi-asserted-by":"crossref","first-page":"H1744","DOI":"10.1152\/ajpheart.00864.2002","article-title":"Sodium restriction prevents cardiac hypertrophy and oxidative stress in Ang II hypertension","volume":"284","author":"Rugale","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R17-28-20210208","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.amjhyper.2005.11.008","article-title":"Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets","volume":"19","author":"Pech","year":"2006","journal-title":"Am J Hypertens"},{"key":"R18-28-20210208","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/hc0102.101399","article-title":"Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage","volume":"105","author":"Shimosawa","year":"2002","journal-title":"Circulation"},{"key":"R19-28-20210208","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.ATV.0000066684.37829.16","article-title":"NAD(P)H oxidase mediates Ang II-induced vascular macrophage infiltration and medial hypertrophy","volume":"23","author":"Liu","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R20-28-20210208","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart: role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am J Pathol"},{"key":"R21-28-20210208","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1210\/en.2002-220120","article-title":"Selective aldosterone blockade prevents Ang II\/salt-induced vascular inflammation in the rat heart","volume":"143","author":"Rocha","year":"2002","journal-title":"Endocrinology"},{"key":"R22-28-20210208","doi-asserted-by":"crossref","first-page":"H336","DOI":"10.1152\/ajpheart.01307.2005","article-title":"ANG II-induced cardiac molecular and cellular events: role of aldosterone","volume":"291","author":"Zhao","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R23-28-20210208","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000255636.11931.a2","article-title":"Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1","volume":"49","author":"Shibata","year":"2007","journal-title":"Hypertension"},{"key":"R24-28-20210208","first-page":"R1070","article-title":"Antihypertensive effect of dietary calcium loading in angiotensin II-salt rats","volume":"261","author":"Ando","year":"1991","journal-title":"Am J Physiol"},{"key":"R25-28-20210208","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/01.HYP.0000232617.48372.cb","article-title":"Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction","volume":"48","author":"Matsui","year":"2006","journal-title":"Hypertension"},{"key":"R26-28-20210208","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.HYP.0000150857.39919.cb","article-title":"Recommendations for blood pressure measurement in humans and experimental animals","volume":"45","author":"Kurtz","year":"2005","journal-title":"Hypertension"},{"key":"R27-28-20210208","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0895-7061(04)00811-8","article-title":"Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the Renin\u2013Angiotensin system","volume":"17","author":"Iglarz","year":"2004","journal-title":"Am J Hypertens"},{"key":"R28-28-20210208","doi-asserted-by":"crossref","first-page":"I241","DOI":"10.1161\/hc37t1.094522","article-title":"Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model","volume":"104","author":"Nishina","year":"2001","journal-title":"Circulation"},{"key":"R29-28-20210208","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.0000174593.88899.68","article-title":"Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1\/2 in rat renal fibroblasts","volume":"46","author":"Nagai","year":"2005","journal-title":"Hypertension"},{"key":"R30-28-20210208","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0008-6363(00)00024-9","article-title":"Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and \u2018overdrive\u2019 of the endothelin system","volume":"46","author":"Yamamoto","year":"2000","journal-title":"Cardiovasc Res"},{"key":"R31-28-20210208","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/01.ASN.0000061777.67332.77","article-title":"Mineralocorticoid effects in the kidney: correlation between ENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+","volume":"14","author":"Muller","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R32-28-20210208","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1507\/endocrj.50.445","article-title":"Expression of 11 beta-hydroxysteroid dehydrogenase type 1 in alveolar epithelial cells in rats","volume":"50","author":"Suzuki","year":"2003","journal-title":"Endocr J"},{"key":"R33-28-20210208","doi-asserted-by":"crossref","first-page":"F348","DOI":"10.1152\/ajprenal.00061.2003","article-title":"Stimulation of 11\u03b2-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake","volume":"285","author":"Norregaard","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"R34-28-20210208","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/physiolgenomics.00165.2004","article-title":"Cardiac gene expression profile in rats with terminal heart failure and cachexia","volume":"20","author":"Wellner","year":"2005","journal-title":"Physiol Genomics"},{"key":"R35-28-20210208","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.RES.74.6.1141","article-title":"Ang II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cell","volume":"74","author":"Griendling","year":"1994","journal-title":"Circ Res"},{"key":"R36-28-20210208","doi-asserted-by":"crossref","first-page":"H1714","DOI":"10.1152\/ajpheart.00486.2006","article-title":"Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity","volume":"292","author":"Liu","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R37-28-20210208","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2005.08.006","article-title":"Activation of AP-1 through reactive oxygen species by angiotensin II in rat cardiomyocytes","volume":"39","author":"Wu","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"R38-28-20210208","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1210\/endo.141.5.7529","article-title":"Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy","volume":"141","author":"Takeda","year":"2000","journal-title":"Endocrinology"},{"key":"R39-28-20210208","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2174\/1389557054553811","article-title":"Moleculer mechanisms of mineralocorticoid receptor antagonism by eplerenone","volume":"5","author":"Hu","year":"2005","journal-title":"Mini Rev Med Chem"},{"key":"R40-28-20210208","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1152\/physiol.00053.2004","article-title":"SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption","volume":"20","author":"McCormick","year":"2005","journal-title":"Physiology"},{"key":"R41-28-20210208","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00109-005-0027-z","article-title":"SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment","volume":"84","author":"Vallon","year":"2006","journal-title":"J Mol Med"},{"key":"R42-28-20210208","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.0000159937.05502.d1","article-title":"Ang II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells","volume":"96","author":"Jaffe","year":"2005","journal-title":"Circ Res"},{"key":"R43-28-20210208","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mce.2003.10.054","article-title":"Aldosterone, mineralocorticoid receptors and vascular inflammation","volume":"217","author":"Funder","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"R44-28-20210208","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJMp048132","article-title":"Aldosterone: villain or bystander?","volume":"351","author":"Dluhy","year":"2004","journal-title":"N Engl J Med"},{"key":"R45-28-20210208","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10741-005-2344-2","article-title":"Mineralocorticoid receptors: distribution and activation","volume":"10","author":"Funder","year":"2005","journal-title":"Heart Fail Rev"},{"key":"R46-28-20210208","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molcel.2005.12.019","article-title":"Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes","volume":"21","author":"Bossis","year":"2006","journal-title":"Mol Cell"},{"key":"R47-28-20210208","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1210\/me.2005-0089","article-title":"The mineralocorticoid receptor: a journey exploring its diversity and specificity of action","volume":"19","author":"Pascual-Le Tallec","year":"2005","journal-title":"Mol Endocrinol"},{"key":"R48-28-20210208","first-page":"505","article-title":"Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects. Relationship between blood pressure and oxidative stress","volume":"54","author":"Suzuki","year":"2004","journal-title":"Arzneimittelforschung"},{"key":"R49-28-20210208","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2003.10.009","article-title":"Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies","volume":"217","author":"Pitt","year":"2004","journal-title":"Mol Cell Endocrinol"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00004872-200807000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T02:00:40Z","timestamp":1618365640000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004872-200807000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e328300a232","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}