{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:32:54Z","timestamp":1791300774898,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1097\/hjh.0b013e32831aedfa","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T03:16:56Z","timestamp":1232421416000},"page":"322-331","source":"Crossref","is-referenced-by-count":59,"title":["Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats"],"prefix":"10.1097","volume":"27","author":[{"given":"Marc","family":"Revermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Barbosa-Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Dony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph T","family":"Schermuly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Morisseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Geisslinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf P","family":"Brandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210208","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/j.jacc.2004.02.037","article-title":"Clinical classification of pulmonary hypertension","volume":"43","author":"Simonneau","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"R2-20-20210208","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cardiores.2006.07.025","article-title":"Hypoxia- and nonhypoxia-related pulmonary hypertension \u2013 established and new therapies","volume":"72","author":"Ghofrani","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R3-20-20210208","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra035488","article-title":"Pulmonary arterial hypertension","volume":"351","author":"Farber","year":"2004","journal-title":"N Engl J Med"},{"key":"R4-20-20210208","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/01.HYP.0000208299.62535.58","article-title":"Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling","volume":"47","author":"Pokreisz","year":"2006","journal-title":"Hypertension"},{"key":"R5-20-20210208","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/46816","article-title":"Cytochrome P450 2C is an EDHF synthase in coronary arteries","volume":"401","author":"Fisslthaler","year":"1999","journal-title":"Nature"},{"key":"R6-20-20210208","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1242\/jcs.02674","article-title":"Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis","volume":"118","author":"Michaelis","year":"2005","journal-title":"J Cell Sci"},{"key":"R7-20-20210208","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"key":"R8-20-20210208","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/hh2101.099268","article-title":"Cytochrome p450 and vascular homeostasis","volume":"89","author":"Fleming","year":"2001","journal-title":"Circ Res"},{"key":"R9-20-20210208","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.prostaglandins.2006.05.004","article-title":"Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)","volume":"82","author":"Inceoglu","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"R10-20-20210208","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.HYP.0000153792.29478.1d","article-title":"Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension","volume":"45","author":"Jung","year":"2005","journal-title":"Hypertension"},{"key":"R11-20-20210208","doi-asserted-by":"crossref","first-page":"18733","DOI":"10.1073\/pnas.0609158103","article-title":"Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors","volume":"103","author":"Xu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R12-20-20210208","doi-asserted-by":"crossref","first-page":"13646","DOI":"10.1073\/pnas.0605908103","article-title":"Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors","volume":"103","author":"Schmelzer","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-20-20210208","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10937409809524557","article-title":"Chronic pulmonary hypertension \u2013 the monocrotaline model and involvement of the hemostatic system","volume":"1","author":"Schultze","year":"1998","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"R14-20-20210208","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1021\/jm070270t","article-title":"Orally bioavailable potent soluble epoxide hydrolase inhibitors","volume":"50","author":"Hwang","year":"2007","journal-title":"J Med Chem"},{"key":"R15-20-20210208","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0006-2952(02)00952-8","article-title":"Structural refinement of inhibitors of urea-based soluble epoxide hydrolases","volume":"63","author":"Morisseau","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"R16-20-20210208","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/01.RES.0000126050.41296.8E","article-title":"Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3\/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension","volume":"94","author":"Schermuly","year":"2004","journal-title":"Circ Res"},{"key":"R17-20-20210208","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.bbrc.2005.02.103","article-title":"Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily","volume":"329","author":"Barbosa-Sicard","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R18-20-20210208","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/BJ20061328","article-title":"Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation","volume":"403","author":"Muller","year":"2007","journal-title":"Biochem J"},{"key":"R19-20-20210208","doi-asserted-by":"crossref","first-page":"H517","DOI":"10.1152\/ajpheart.00953.2005","article-title":"Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature","volume":"291","author":"Dhanasekaran","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R20-20-20210208","doi-asserted-by":"crossref","first-page":"H142","DOI":"10.1152\/ajpheart.00783.2006","article-title":"Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K\/Akt signaling pathways","volume":"293","author":"Yang","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R21-20-20210208","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1183\/09031936.03.00038903","article-title":"Inflammation in pulmonary arterial hypertension","volume":"22","author":"Dorfmuller","year":"2003","journal-title":"Eur Respir J"},{"key":"R22-20-20210208","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/taap.1998.8458","article-title":"Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells","volume":"151","author":"Thomas","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"R23-20-20210208","doi-asserted-by":"crossref","first-page":"L872","DOI":"10.1152\/ajplung.00309.2006","article-title":"Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension","volume":"292","author":"McMurtry","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R24-20-20210208","first-page":"H2113","article-title":"14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells","volume":"275","author":"Fang","year":"1998","journal-title":"Am J Physiol"},{"key":"R25-20-20210208","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/01.RES.0000017727.35930.33","article-title":"Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids","volume":"90","author":"Sun","year":"2002","journal-title":"Circ Res"},{"key":"R26-20-20210208","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1378\/chest.06-2243","article-title":"A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats","volume":"132","author":"Sawada","year":"2007","journal-title":"Chest"},{"key":"R27-20-20210208","doi-asserted-by":"crossref","first-page":"L335","DOI":"10.1152\/ajplung.2000.278.2.L335","article-title":"Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries","volume":"278","author":"Zhu","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R28-20-20210208","doi-asserted-by":"crossref","first-page":"12260","DOI":"10.1016\/S0021-9258(18)31383-8","article-title":"Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins","volume":"268","author":"Carroll","year":"1993","journal-title":"J Biol Chem"},{"key":"R29-20-20210208","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.R100030200","article-title":"Epoxygenase pathways of arachidonic acid metabolism","volume":"276","author":"Zeldin","year":"2001","journal-title":"J Biol Chem"},{"key":"R30-20-20210208","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1073\/pnas.0503279102","article-title":"Soluble epoxide hydrolase is a therapeutic target for acute inflammation","volume":"102","author":"Schmelzer","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R31-20-20210208","first-page":"L65","article-title":"Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase","volume":"269","author":"Ishizaki","year":"1995","journal-title":"Am J Physiol"},{"key":"R32-20-20210208","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nm0597-562","article-title":"Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase","volume":"3","author":"Moghaddam","year":"1997","journal-title":"Nat Med"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004872-200902000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:30:31Z","timestamp":1786037431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004872-200902000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e32831aedfa","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}