{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:34:14Z","timestamp":1790058854298,"version":"4.0.1"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1097\/hjh.0b013e32831bc778","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T08:16:56Z","timestamp":1232439416000},"page":"386-396","source":"Crossref","is-referenced-by-count":35,"title":["Development of cardiovascular disease due to renal insufficiency in male sheep following fetal unilateral nephrectomy"],"prefix":"10.1097","volume":"27","author":[{"given":"Reetu R","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M","family":"Denton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Bertram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Jefferies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Schneider-Kolsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-27-20210208","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0272-6386(12)80967-X","article-title":"Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury","volume":"23","author":"Brenner","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"R2-27-20210208","first-page":"S124","article-title":"Nephron mass as a risk factor for progression of renal disease","volume":"63","author":"Brenner","year":"1997","journal-title":"Kidney Int Suppl"},{"key":"R3-27-20210208","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11255-006-0044-z","article-title":"The epidemics of cardiovascular disease in elderly patients with chronic kidney disease: two facets of the same problem","volume":"38","author":"Covic","year":"2006","journal-title":"Int J Urol Nephrol"},{"key":"R4-27-20210208","first-page":"275","article-title":"Focal and segmental glomerulosclerosis and proteinuria associated with unilateral renal agenesis","volume":"46","author":"Kiprov","year":"1982","journal-title":"Lab Invest"},{"key":"R5-27-20210208","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0022-5347(17)36710-1","article-title":"Prognosis of children with solitary kidney after unilateral nephrectomy","volume":"148","author":"Argueso","year":"1992","journal-title":"J Urol"},{"key":"R6-27-20210208","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000095735","article-title":"Blood pressure, renal function, and proteinuria in children with unilateral renal agenesis","volume":"29","author":"Seeman","year":"2006","journal-title":"Kidney Blood Press Res"},{"key":"R7-27-20210208","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00126097-200110000-00007","article-title":"Ambulatory blood pressure monitoring in children with a solitary kidney: a comparison between unilateral renal agenesis and uninephrectomy","volume":"2001","author":"Mei-Zahav","year":"2001","journal-title":"Blood Press Monit"},{"key":"R8-27-20210208","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med"},{"key":"R9-27-20210208","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.HYP.0000050961.70182.56","article-title":"Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice","volume":"41","author":"Cullen-McEwen","year":"2003","journal-title":"Hypertension"},{"key":"R10-27-20210208","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMoa020549","article-title":"Nephron number in patients with primary hypertension","volume":"348","author":"Keller","year":"2003","journal-title":"N Engl J Med"},{"key":"R11-27-20210208","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.HYP.0000019131.77075.54","article-title":"Fetal uninephrectomy leads to postnatal hypertension and compromised renal function","volume":"39","author":"Moritz","year":"2002","journal-title":"Hypertension"},{"key":"R12-27-20210208","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1440-1754.2008.01315.x","article-title":"Hypertension and microalbuminuria in children with congenital solitary kidneys","volume":"44","author":"Schreuder","year":"2008","journal-title":"J Pediatr Child Health"},{"key":"R13-27-20210208","first-page":"503","article-title":"Prenatal corticosterone exposure results in altered AT1\/AT2, nephron deficit and hypertension in the rat offspring","volume":"579","author":"Singh","year":"2007","journal-title":"J Phys"},{"key":"R14-27-20210208","first-page":"929","article-title":"Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment","volume":"549","author":"Wintour","year":"2003","journal-title":"J Phys"},{"key":"R15-27-20210208","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/01.HYP.38.3.337","article-title":"Hypertension after neonatal uninephrectomy in rats precedes glomerular damage","volume":"38","author":"Woods","year":"2001","journal-title":"Hypertension"},{"key":"R16-27-20210208","doi-asserted-by":"crossref","first-page":"R462","DOI":"10.1152\/ajpregu.00079.2006","article-title":"Combined prenatal and postnatal protein restriction influences adult kidney structure, function and arterial pressure","volume":"292","author":"Hoppe","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R17-27-20210208","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1203\/00006450-200104000-00005","article-title":"Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats","volume":"49","author":"Woods","year":"2001","journal-title":"Pediatr Res"},{"key":"R18-27-20210208","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/01.HYP.0000036455.62159.7E","article-title":"Programming effects of short prenatal exposure to dexamethasone in sheep","volume":"40","author":"Dodic","year":"2002","journal-title":"Hypertension"},{"key":"R19-27-20210208","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ncpendmet0515","article-title":"Mechanisms of disease: glucocorticoids, their placental metabolism and fetal \u2018programming\u2019 of adult pathophysiology","volume":"3","author":"Seckl","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"S1","key":"R20-27-20210208","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/07853890.1999.11904392","article-title":"Fetal origins of cardiovascular disease","volume":"31","author":"Barker","year":"1999","journal-title":"Ann Med"},{"key":"R21-27-20210208","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1681\/ASN.2005020160","article-title":"Developmental antecedents of cardiovascular disease: a historical perspective","volume":"16","author":"Barker","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R22-27-20210208","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal undernutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"R23-27-20210208","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1681\/ASN.V132406","article-title":"Compensatory renal growth after unilateral nephrectomy in the ovine fetus","volume":"13","author":"Douglas-Denton","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R24-27-20210208","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1440-1681.1999.03155.x","article-title":"Foetal fluid balance and hormone status following nephrectomy in the foetal sheep","volume":"26","author":"Moritz","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R25-27-20210208","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s004670050587","article-title":"Functional development of the meso-metanephros","volume":"13","author":"Moritz","year":"1999","journal-title":"Pediatr Nephrol"},{"key":"R26-27-20210208","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/dbio.1997.8629","article-title":"Model systems for the study of kidney development: analysis of organ induction and patterning","volume":"188","author":"Vize","year":"1997","journal-title":"Dev Biol"},{"key":"R27-27-20210208","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1523-1755.2005.00147.x","article-title":"Reduced renal reserve and increased cardiac output in adult female sheep uninephrectomized as fetuses","volume":"67","author":"Moritz","year":"2005","journal-title":"Kidney Int"},{"key":"R28-27-20210208","doi-asserted-by":"crossref","first-page":"R697","DOI":"10.1152\/ajpregu.00766.2006","article-title":"Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function","volume":"292","author":"Denton","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R29-27-20210208","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0008-6363(01)00527-2","article-title":"Sex hormones and hypertension","volume":"53","author":"Dubey","year":"2002","journal-title":"Cardiovasc Res"},{"key":"R30-27-20210208","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/cs0940149","article-title":"An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep","volume":"94","author":"Dodic","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"R31-27-20210208","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/hh1901.097086","article-title":"Impaired cardiac functional reserve and left ventricular hypertrophy in adult sheep after prenatal dexamethasone exposure","volume":"89","author":"Dodic","year":"2001","journal-title":"Circ Res"},{"key":"R32-27-20210208","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2007.09.004","article-title":"A method for assessment of blood volume parameters in pregnant sheep using fluorescein-labelled dextran","volume":"29","author":"Rumball","year":"2007","journal-title":"Placenta"},{"key":"R33-27-20210208","doi-asserted-by":"crossref","first-page":"R441","DOI":"10.1152\/ajpregu.1999.277.2.R441","article-title":"A five parameter logistic equation for investigating asymmetry of curvature in baroreflex studies","volume":"277","author":"Ricketts","year":"1999","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R34-27-20210208","doi-asserted-by":"crossref","first-page":"F190","DOI":"10.1152\/ajprenal.1982.242.2.F190","article-title":"Functional adaptation to reduced renal mass in early development","volume":"242","author":"Chevalier","year":"1982","journal-title":"Am J Physiol Renal Physiol"},{"key":"R35-27-20210208","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1084-2756(03)00042-3","article-title":"Molecular determinants of sodium and water balance during early human development","volume":"8","author":"Holtback","year":"2003","journal-title":"Semin Neonatol"},{"key":"R36-27-20210208","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.1973.sp010081","article-title":"Compensatory renal growth after unilateral nephrectomy in the new-born rat","volume":"228","author":"Dicker","year":"1973","journal-title":"J Physiol"},{"key":"R37-27-20210208","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/01.hjh.0000209991.48928.c4","article-title":"Microalbuminuria and tubular proteinuria as risk predictors of cardiovascular morbidity and mortality in essential hypertension: final results of a prospective long-term study (MARPLE Study)*","volume":"24","author":"Schrader","year":"2006","journal-title":"J Hypertens"},{"key":"R38-27-20210208","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/ajh\/1.4.335","article-title":"Glomeruli and blood pressure. Less one, more the other?","volume":"1","author":"Brenner","year":"1988","journal-title":"Am J Hypertens"},{"key":"R39-27-20210208","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11255-004-0873-6","article-title":"The aging kidney: a review \u2013 part I","volume":"37","author":"Silva","year":"2005","journal-title":"Int Urol Nephrol"},{"key":"R40-27-20210208","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1523-1755.2005.67097.x","article-title":"Pathways to nephron loss starting from glomerular diseases: insights from animal models","volume":"67","author":"Kriz","year":"2005","journal-title":"Kidney Int"},{"key":"R41-27-20210208","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s00467-007-0524-0","article-title":"Mechanisms of progression of chronic kidney disease","volume":"22","author":"Fogo","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"R42-27-20210208","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0002-8703(62)90195-3","article-title":"The hemodynamics in labile hypertension.","volume":"63","author":"Eich","year":"1962","journal-title":"Am Heart J"},{"key":"R43-27-20210208","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.CIR.34.2.299","article-title":"Hemodynamics in labile hypertension. A follow-up study","volume":"34","author":"Eich","year":"1966","journal-title":"Circulation"},{"key":"R44-27-20210208","doi-asserted-by":"crossref","first-page":"II","DOI":"10.1161\/01.RES.28.5.II-76","article-title":"Whole-body circulatory autoregulation and hypertension","volume":"28","author":"Coleman","year":"1971","journal-title":"Circ Res"},{"key":"R45-27-20210208","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/sj.bjp.0705366","article-title":"Increased peripheral resistance in heart failure: new evidence suggests an alteration in vascular smooth muscle function","volume":"139","author":"Ledoux","year":"2003","journal-title":"Br J Pharmacol"},{"key":"R46-27-20210208","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/01.CIR.100.12.1305","article-title":"Single-unit sympathetic discharge: quantitative assessment in human hypertensive disease","volume":"100","author":"Greenwood","year":"1999","journal-title":"Circulation"},{"key":"R47-27-20210208","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/01.CIR.0000039106.89299.AB","article-title":"Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability","volume":"106","author":"Lucini","year":"2002","journal-title":"Circulation"},{"key":"R48-27-20210208","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJM199904293401704","article-title":"Reduction of sympathetic hyperactivity by enalapril n patients with chronic renal failure","volume":"340","author":"Ligtenberg","year":"1999","journal-title":"N Engl J Med"},{"key":"R49-27-20210208","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1161\/01.CIR.92.10.2886","article-title":"Exercise capacity in hypertrophic cardiomyopathy","volume":"92","author":"Lele","year":"1995","journal-title":"Circulation"},{"key":"R50-27-20210208","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0002-9149(96)00592-9","article-title":"Diminished contractile reserve in patients with left ventricular hypertrophy and increased end-systolic stress during dobutamine stress echocardiography","volume":"78","author":"Fontanet","year":"1996","journal-title":"Am J Cardiol"},{"key":"R51-27-20210208","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/hrt.2004.042473","article-title":"Left ventricular hypertrophy in hypertension: its arrhythmogenic potential","volume":"91","author":"Kahan","year":"2005","journal-title":"Heart"},{"key":"R52-27-20210208","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/ki.1996.401","article-title":"Left ventricular abnormalities in children, adolescents and young adults with renal disease","volume":"50","author":"Johnstone","year":"1996","journal-title":"Kidney Int"},{"key":"R53-27-20210208","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1523-1755.2004.00525.x","article-title":"Impaired left ventricular diastolic function in children with chronic renal failure","volume":"65","author":"Mitsnefes","year":"2004","journal-title":"Kidney Int"},{"key":"R54-27-20210208","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/0735-1097(92)90617-V","article-title":"Patterns of left ventricular hypertrophy and geometric remodelling in essential hypertension","volume":"19","author":"Ganau","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"R55-27-20210208","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0735-1097(95)00282-8","article-title":"Gender differences and aging: effects on human heart","volume":"26","author":"Olivetti","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"R56-27-20210208","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ymgme.2004.04.013","article-title":"Novel troponin T mutation in familial dilated cardiomyopathy with gender-dependant severity","volume":"2000","author":"Stefanelli","year":"2004","journal-title":"Mol Genet Metab"},{"key":"R57-27-20210208","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.exger.2005.01.008","article-title":"Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system","volume":"40","author":"Baylis","year":"2005","journal-title":"Exp Gerontol"},{"key":"R58-27-20210208","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.mnh.0000222698.30207.aa","article-title":"Epidemiology of nondialysis-requiring chronic kidney disease and cardiovascular disease","volume":"15","author":"Go","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00004872-200902000-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T06:01:40Z","timestamp":1632981700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004872-200902000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e32831bc778","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}