{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:55:26Z","timestamp":1778529326748,"version":"3.51.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1097\/hjh.0b013e32834bbb4d","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T20:06:56Z","timestamp":1317758816000},"page":"2236-2245","source":"Crossref","is-referenced-by-count":28,"title":["Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition"],"prefix":"10.1097","volume":"29","author":[{"given":"Shinji","family":"Inaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Furuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Senba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Okayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitsuo","family":"Higaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-24-20210208","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","article-title":"Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE); a randomised trial against atenolol.","volume":"359","author":"Dahlof","year":"2002","journal-title":"Lancet"},{"key":"R2-24-20210208","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0140-6736(07)60669-2","article-title":"Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study.","volume":"369","author":"Mochizuki","year":"2007","journal-title":"Lancet"},{"key":"R3-24-20210208","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ Res"},{"key":"R4-24-20210208","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.","volume":"275","author":"Tipnis","year":"2000","journal-title":"J Biol Chem"},{"key":"R5-24-20210208","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.","volume":"277","author":"Vickers","year":"2002","journal-title":"J Biol Chem"},{"key":"R6-24-20210208","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1152\/physiolgenomics.00312.2005","article-title":"ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.","volume":"27","author":"Diez-Freire","year":"2006","journal-title":"Physiol Genomics"},{"key":"R7-24-20210208","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nature00786","article-title":"Angiotensin-converting enzyme 2 is an essential regulator of heart function.","volume":"417","author":"Crackower","year":"2002","journal-title":"Nature"},{"key":"R8-24-20210208","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/hr.2009.74","article-title":"Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-mas receptor axis.","volume":"32","author":"Iwai","year":"2009","journal-title":"Hypertens Res"},{"key":"R9-24-20210208","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cardiores.2006.09.006","article-title":"ACE2 of the heart: from angiotensin I to angiotensin (1-7).","volume":"73","author":"Keidar","year":"2007","journal-title":"Cardiovasc Res"},{"key":"R10-24-20210208","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/HYPERTENSIONAHA.108.114280","article-title":"Molecular mechanisms involved in the angiotensin-(1-7)Mas signaling pathway in cardiomyocytes.","volume":"52","author":"Dias-Peixoto","year":"2008","journal-title":"Hypertension"},{"key":"R11-24-20210208","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1161\/HYPERTENSIONAHA.109.143255","article-title":"Angiotensin-(1-7) prevents cardiomyocyte pathological remodeling through a nitric oxideguanosine 3, 5-cyclic monophosphate-dependent pathway.","volume":"55","author":"Gomes","year":"2010","journal-title":"Hypertension"},{"key":"R12-24-20210208","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/CIRCULATIONAHA.104.510461","article-title":"Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.","volume":"111","author":"Ferrario","year":"2005","journal-title":"Circulation"},{"key":"R13-24-20210208","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1291\/hypres.29.865","article-title":"Olmesartan is an angiotensin II receptor blocker with an inhibitory effect on angiotensin-converting enzyme.","volume":"29","author":"Agata","year":"2006","journal-title":"Hypertens Res"},{"key":"R14-24-20210208","doi-asserted-by":"crossref","first-page":"11617","DOI":"10.1016\/S0021-9258(19)50246-0","article-title":"Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes.","volume":"268","author":"Fukamizu","year":"1993","journal-title":"J Biol Chem"},{"key":"R15-24-20210208","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/STROKEAHA.108.519801","article-title":"Exaggeration of focal cerebral ischemia in transgenic mice carrying human renin and human angiotensinogen genes.","volume":"40","author":"Inaba","year":"2009","journal-title":"Stroke"},{"key":"R16-24-20210208","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/hq0102.102277","article-title":"Effect of angiotensin II type 1 receptor blockade on cardiac remodeling in angiotensin II type 2 receptor null mice.","volume":"22","author":"Wu","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R17-24-20210208","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/hq0102.102189","article-title":"Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury.","volume":"22","author":"Szocs","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R18-24-20210208","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.108.123612","article-title":"Continuous activation of renin-angiotensin system impairs cognitive function in reninangiotensinogen transgenic mice.","volume":"53","author":"Inaba","year":"2009","journal-title":"Hypertension"},{"key":"R19-24-20210208","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ajh.2008.344","article-title":"Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists.","volume":"22","author":"Inaba","year":"2009","journal-title":"Am J Hypertens"},{"key":"R20-24-20210208","doi-asserted-by":"crossref","first-page":"37","DOI":"10.33549\/physiolres.930000.49.37","article-title":"The potential role of nitric oxide in the hypertrophic growth of the left ventricle.","volume":"49","author":"Simko","year":"2000","journal-title":"Physiol Res"},{"key":"R21-24-20210208","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1161\/01.CIR.0000029749.16101.44","article-title":"Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.","volume":"106","author":"Suda","year":"2002","journal-title":"Circulation"},{"key":"R22-24-20210208","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00109-005-0718-5","article-title":"Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy.","volume":"84","author":"Lieb","year":"2006","journal-title":"J Mol Med"},{"key":"R23-24-20210208","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/expphysiol.2005.031096","article-title":"Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.","volume":"90","author":"Huentelman","year":"2005","journal-title":"Exp Physiol"},{"key":"R24-24-20210208","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/080370598437583","article-title":"Tissue angiotensin II concentration in the heart and kidneys in transgenic Tsukuba hypertensive mice.","volume":"7","author":"Kai","year":"1998","journal-title":"Blood Press"},{"key":"R25-24-20210208","doi-asserted-by":"crossref","first-page":"H2373","DOI":"10.1152\/ajpheart.00426.2008","article-title":"Regulation of ACE2 in cardiac myocytes and fibroblasts.","volume":"295","author":"Gallagher","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R26-24-20210208","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/ajh.2010.51","article-title":"Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.","volume":"23","author":"Trask","year":"2010","journal-title":"Am J Hypertens"},{"key":"R27-24-20210208","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.HYP.0000175813.04375.8a","article-title":"Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart.","volume":"46","author":"Castro","year":"2005","journal-title":"Hypertension"},{"key":"R28-24-20210208","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"R29-24-20210208","doi-asserted-by":"crossref","first-page":"E355","DOI":"10.1152\/ajpendo.00632.2006","article-title":"Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat.","volume":"293","author":"Whaley-Connell","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R30-24-20210208","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidase-dependent redox signaling in cardiac hypertrophy, remodeling and failure.","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R31-24-20210208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cardiores.2007.04.007","article-title":"Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.","volume":"75","author":"Oudit","year":"2007","journal-title":"Cardiovasc Res"},{"key":"R32-24-20210208","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/HYPERTENSIONAHA.109.141622","article-title":"Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus.","volume":"55","author":"Gwathmey","year":"2010","journal-title":"Hypertension"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00004872-201111000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T12:43:38Z","timestamp":1741783418000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004872-201111000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e32834bbb4d","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}