{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:24:30Z","timestamp":1788805470867,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1097\/hjh.0b013e328363570c","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T13:48:03Z","timestamp":1377784083000},"page":"2085-2093","source":"Crossref","is-referenced-by-count":55,"title":["Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy"],"prefix":"10.1097","volume":"31","author":[{"given":"Christoph D.","family":"Schumacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans R.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-24-20210208","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1056\/NEJM197203022860901","article-title":"Essential hypertension: renin and aldosterone, heart attack and stroke.","volume":"286","author":"Brunner","year":"1972","journal-title":"N Engl J Med"},{"key":"R2-24-20210208","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"R4-24-20210208","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms.","volume":"364","author":"Zannad","year":"2011","journal-title":"N Engl J Med"},{"key":"R5-24-20210208","first-page":"153","article-title":"Why are mineralocorticoid receptor antagonists cardioprotective Naunyn Schmiedebergs Arch P","volume":"374","author":"Chai","year":"2006","journal-title":"harmacol"},{"key":"R6-24-20210208","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.0000201443.63240.a7","article-title":"Effects of aldosterone on the vasculature.","volume":"47","author":"Schiffrin","year":"2006","journal-title":"Hypertension"},{"key":"R7-24-20210208","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1210\/er.2008-0016","article-title":"History of aromatase: saga of an important biological mediator and therapeutic target.","volume":"30","author":"Santen","year":"2009","journal-title":"Endocr Rev"},{"key":"R8-24-20210208","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1021\/jm00106a038","article-title":"Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.","volume":"34","author":"Browne","year":"1991","journal-title":"J Med Chem"},{"key":"R9-24-20210208","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/1097-0142(19900315)65:6<1279::AID-CNCR2820650604>3.0.CO;2-3","article-title":"A phase I trial of CGS 16949A. A new aromatase inhibitor.","volume":"65","author":"Lipton","year":"1990","journal-title":"Cancer"},{"key":"R10-24-20210208","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/01.hjh.0000226183.98439.b3","article-title":"Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition J H","volume":"24","author":"Menard","year":"2006","journal-title":"ypertens"},{"key":"R11-24-20210208","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1152\/japplphysiol.00611.2003","article-title":"Diurnal variation of aldosterone and plasma renin activity: timing relation to melatonin and cortisol and consistency after prolonged bed rest.","volume":"96","author":"Hurwitz","year":"2004","journal-title":"J Appl Physiol"},{"key":"R13-24-20210208","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/CIRCULATIONAHA.111.029892","article-title":"Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial.","volume":"124","author":"Calhoun","year":"2011","journal-title":"Circulation"},{"key":"R14-24-20210208","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/HYPERTENSIONAHA.110.157271","article-title":"Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.","volume":"56","author":"Amar","year":"2010","journal-title":"Hypertension"},{"key":"R15-24-20210208","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1751-7176.2012.00667.x","article-title":"The effects of aldosterone synthase inhibition on aldosterone and cortisol in patients with hypertension: a phase II, randomized, double-blind, placebo-controlled, multicenter study.","volume":"14","author":"Andersen","year":"2012","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"R16-24-20210208","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/jch.12051","article-title":"Study of aldosterone synthase inhibition as an add-on therapy in resistant hypertension.","volume":"15","author":"Karns","year":"2013","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"R17-24-20210208","first-page":"571","article-title":"The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects.","volume":"74","author":"Trunet","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"R18-24-20210208","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1210\/jcem-53-1-58","article-title":"Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.","volume":"53","author":"Dunn","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"R19-24-20210208","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/edrv-10-3-232","article-title":"The free hormone hypothesis: a physiologically based mathematical model.","volume":"10","author":"Mendel","year":"1989","journal-title":"Endocr Rev"},{"key":"R20-24-20210208","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"R21-24-20210208","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-5793(99)01667-1","article-title":"Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors.","volume":"464","author":"Hellal-Levy","year":"1999","journal-title":"FEBS Lett"},{"key":"R22-24-20210208","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/jc.2007-2734","article-title":"Treatment of adrenocorticotropin-dependent Cushings syndrome: a consensus statement.","volume":"93","author":"Biller","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R23-24-20210208","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0889-8529(05)70064-5","article-title":"Medical therapy for Cushings disease.","volume":"28","author":"Sonino","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R24-24-20210208","first-page":"1162","article-title":"The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis.","volume":"70","author":"Demers","year":"1990","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/HJH.0b013e328363570c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T19:41:39Z","timestamp":1621885299000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004872-201310000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/hjh.0b013e328363570c","relation":{},"ISSN":["0263-6352"],"issn-type":[{"value":"0263-6352","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}