{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:53:06Z","timestamp":1761709986948,"version":"3.43.0"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To explore on the association between nucleic acid turning-negative-time and traditional Chinese medicine (TCM) symptoms in coronavirus disease 2019 (COVID-19) patients with the Omicron variant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method:<\/jats:title>\n            <jats:p>For this retrospective cross-sectional study, we enrolled 189 patients with COVID-19 (age 20\u201390 years) were included. multiple linear regression models were used to investigate the TCM symptoms affecting the nucleic acid turning-negative-time of COVID-19 patients, during the process of data analysis, taking with nucleic acid turning-negative-time as the dependent variable, and TCM symptoms as independent variables, and at the same time, sex, age, hypertension, diabetes, and coronary heart disease were as confounding variables.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The study found that the most common TCM symptoms of COVID-19 patients with Omicron were cough, dry throat, expectoration, fever, sore throat, pharyngeal itching, running nose, and nasal congestion. Regression analysis showed that the fit regressive equation showed a significant difference (F = 4.286, P &lt; 0.001), R = 0.400, the adjusted R\u20092 = 0.123, and three variables in the regression equation showed significant difference (P &lt; 0. 05). The results showed that nucleic acid turning-negative-time was mostly related to constipation, fever, and expectoration. If the patients had the symptoms of constipation, fever, and expectoration; that is, if patients showed these symptoms, the turning-negative-time of nucleic acid in patients with Omicron will be prolonged.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Treatment based on symptoms for patients with constipation, fever, and expectoration may have important clinical significance for the COVID-19 patients with Omicron.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hm9.0000000000000037","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T18:00:43Z","timestamp":1664215243000},"page":"207-209","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Symptoms associated with nucleic acid turning-negative-time in COVID-19 patients?"],"prefix":"10.1097","volume":"2","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Feng","sequence":"additional","affiliation":[{"name":"Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunzhong","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingchi","family":"Luo","sequence":"additional","affiliation":[{"name":"Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"issue":"5","key":"R1-20250806","first-page":"545","article-title":"Clinical observation of Xuanfei Baidu Granule in the treatment of COVID-19 (Omicron).","volume":"39","author":"Feng","year":"2022","journal-title":"Tianjin J Tradit Chin Med"},{"issue":"1","key":"R2-20250806","first-page":"26","article-title":"COVID-19 super mutant: Omicron.","volume":"74","author":"Wang","year":"2022","journal-title":"Science"},{"issue":"1","key":"R3-20250806","first-page":"14","article-title":"Treating corona virus disease 2019 from theory of \u201cLung and Large Intestine Being Interior-exteriorly Related\u201d.","volume":"43","author":"Liu","year":"2020","journal-title":"J Chengdu Univ TCM"},{"issue":"1","key":"R4-20250806","first-page":"35","article-title":"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (Full version).","volume":"30","author":"Jin","year":"2020","journal-title":"New Med"}],"container-title":["Acupuncture and Herbal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/HM9.0000000000000037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:00:57Z","timestamp":1754474457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/HM9.0000000000000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/hm9.0000000000000037","relation":{},"ISSN":["2097-0226"],"issn-type":[{"type":"print","value":"2097-0226"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}