{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:45:26Z","timestamp":1788777926550,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count. This may lead to an increased risk of hemorrhagic stroke but a lower rate of nonhemorrhagic stroke. The goal of this study was to evaluate the association between ITP and both hemorrhagic and nonhemorrhagic strokes using a large database.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We used the Nationwide Inpatient Sample (NIS) database to analyze the occurrence of hemorrhagic and nonhemorrhagic stroke in patients with and without a diagnosis of ITP from 2005 to 2014.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Univariate analysis revealed a higher incidence of hemorrhagic stroke in patients with ITP in the year studied. (for example, in 2005: OR, 1.75; 95% CI, 1.57\u20131.94; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; 2014: OR, 2.19; 95% CI, 2.03\u20132.36; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). After adjusting for age, gender, race, and hypertension, hemorrhagic stroke remained significantly associated with ITP (in 2005: OR, 1.85; 95% CI, 1.49\u20131.89; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; 2014: OR, 2.01; 95% CI, 1.86\u20132.18; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) for all the years studied. Nonhemorrhagic stroke occurred at a lower rate in patients with ITP in most years (2006: OR, 0.91; 95% CI, 0.85\u20130.97; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.004; 2014: OR, 0.88; 95% CI, 0.83\u20130.93; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Multivariate analysis confirmed a higher rate of nonhemorrhagic stroke in ITP patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Our analysis showed that there was a higher rate of hemorrhagic stroke but a lower rate of ischemic stroke in ITP patients, suggesting an important role of platelets in the occurrence of stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hpc.0000000000000332","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T18:06:42Z","timestamp":1708538802000},"page":"26-29","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Idiopathic Thrombocytopenic Purpura and Hemorrhagic and Nonhemorrhagic Stroke"],"prefix":"10.1097","volume":"23","author":[{"given":"Rachna","family":"Guntu","sequence":"first","affiliation":[{"name":"University of Arizona, College of Medicine Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Arizona, College of Medicine Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Movahed","sequence":"additional","affiliation":[{"name":"University of Arizona, College of Medicine Phoenix, AZ"},{"name":"University of Arizona, Sarver Heart Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrtash","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"University of Arizona, College of Medicine Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoosh","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"University of Arizona, College of Medicine Phoenix, AZ"},{"name":"Pima Community College, Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"R1-20250506","first-page":"e56","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association [published correction appears in circulation. 2020 Jan 14;141(2):e33].","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"R2-20250506","doi-asserted-by":"crossref","first-page":"3B","DOI":"10.1016\/0002-9149(95)80003-B","article-title":"Role of thrombosis in atherosclerosis and its complications.","volume":"75","author":"Falk","year":"1995","journal-title":"Am J Cardiol"},{"key":"R3-20250506","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1161\/01.STR.31.1.123","article-title":"Rate of stroke recurrence in patients with primary intracerebral hemorrhage.","volume":"31","author":"Hill","year":"2000","journal-title":"Stroke"},{"key":"R4-20250506","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/1076029611425380","article-title":"Ischemic stroke in the setting of chronic immune thrombocytopenia in an elderly patient\u2013a therapeutic dilemma.","volume":"18","author":"De La Pe\u00f1a","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"key":"R5-20250506","first-page":"405","article-title":"Evaluating association between idiopathic thrombocytopenic purpura and hypertension.","volume":"11","author":"Davis","year":"2021","journal-title":"Am J Blood Res"},{"key":"R6-20250506","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s00277-020-04170-8","article-title":"Idiopathic thrombocytopenic purpura is strongly associated with higher prevalence of aortic valve disease.","volume":"99","author":"Haseefa","year":"2020","journal-title":"Ann Hematol"},{"key":"R7-20250506","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/ijlh.12474","article-title":"Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke.","volume":"38","author":"Du","year":"2016","journal-title":"Int J Lab Hematol"},{"key":"R8-20250506","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2217\/fca-2020-0183","article-title":"The presence of idiopathic thrombocytopenic purpura correlates with lower rate of acute ST-elevation myocardial infarction.","volume":"17","author":"Davis","year":"2021","journal-title":"Future Cardiol"},{"key":"R9-20250506","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/clc.23287","article-title":"Impact of immune thrombocytopenic purpura on clinical outcomes in patients with acute myocardial infarction.","volume":"43","author":"Chehab","year":"2020","journal-title":"Clin Cardiol"},{"key":"R10-20250506","first-page":"e1904","article-title":"Thrombotic paradox: ischaemic stroke in immune thrombocytopaenia. 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