{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T23:11:53Z","timestamp":1794611513749,"version":"4.9.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Left ventricular pseudoaneurysm (LVPA) is a rare mechanical complication of acute myocardial infarction (MI) associated with significant mortality. Given the paucity of available data in the literature, we sought to pool existing evidence to better understand the current management strategies and outcomes. Electronic search was performed in February 2025 to identify all studies reporting management of post-MI LVPA. A total of 158 reports, with a total of 159 patients, were included. Patient-level data were extracted for analysis. A total of 159 patients were included in the analysis. The median age was 65 years [Interquartile range (IQR), 57\u201375], and 70% (106\/159) of patients were male. The most frequent site of MI was the inferior wall (31.4%, 49\/156), and the most common method of MI management was thrombolysis (49%, 64\/131). The median time from MI to presentation signs\/symptoms of LVPA was 21 days (IQR, 0\u2013152). The most common LVPA location was the anterior\/apical wall (27.7%, 44\/159). Sixty-six percent of patients (105\/159) underwent surgical repair, while 22% of patients (35\/159) were managed medically, and 5.7% (9\/159) of patients underwent transcatheter repair. In-hospital\/30-day mortality was 10% (16\/159), with operative mortality after surgical repair of 4.8% (5\/105). Mortality from reoperative surgery was 18.8% (3\/16) as opposed to 2.2% (2\/89) in patients without redo sternotomy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). Periprocedural mortality among patients treated with transcatheter intervention occurred in a single case (11.1%), involving a patient with prior coronary artery bypass grafting. At a median follow-up of 6 months (IQR, 1\u201312), overall survival was 86.1% (137\/159). Surgery remains the standard therapy of LVPA, with acceptable operative risk; however, reoperative sternotomy carries a higher surgical risk. In carefully selected patients, percutaneous repair may serve as a viable alternative to surgery.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/hpc.0000000000000424","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:15Z","timestamp":1783011495000},"page":"e0424","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Management and Outcomes of Postmyocardial Infarction Left Ventricular Pseudoaneurysm: A Case-level Systematic Review"],"prefix":"10.1097","volume":"25","author":[{"given":"Chaitanya","family":"Karimanasseri","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daler","family":"Rahimov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Sankisa","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeem","family":"Nasher","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeeba","family":"Allimulla","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Vizzeswarapu","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstadinos A.","family":"Plestis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Entwistle","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Bavaria","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vakhtang","family":"Tchantchaleishvili","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"R1-20260821","doi-asserted-by":"crossref","first-page":"290","DOI":"10.21037\/acs-2022-ami-25","article-title":"Left ventricular pseudoaneurysm: the niche of post-infarction mechanical complications.","volume":"11","author":"Torchio","year":"2022","journal-title":"Ann Cardiothorac Surg"},{"key":"R2-20260821","first-page":"47","article-title":"Surgical treatment of post-infarction left ventricular pseudoaneurysm: a two-decade experience.","volume":"34","author":"Eren","year":"2007","journal-title":"Tex Heart Inst J"},{"key":"R3-20260821","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0735-1097(98)00290-3","article-title":"Left ventricular pseudoaneurysm.","volume":"32","author":"Frances","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"R4-20260821","doi-asserted-by":"crossref","first-page":"299","DOI":"10.7326\/0003-4819-128-4-199802150-00010","article-title":"Clinical profile and outcome in 52 patients with cardiac pseudoaneurysm.","volume":"128","author":"Yeo","year":"1998","journal-title":"Ann Intern Med"},{"key":"R5-20260821","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.amsu.2017.03.013","article-title":"Surgical treatment of post-infarction left ventricular pseudoaneurysm: case series highlighting various surgical strategies.","volume":"16","author":"Prifti","year":"2017","journal-title":"Ann Med Surg (Lond)."},{"key":"R6-20260821","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/hc1402.104527","article-title":"Images in cardiovascular medicine. False left ventricular aneurysm documented by magnetic resonance imaging.","volume":"105","author":"S\u00f8rensen","year":"2002","journal-title":"Circulation"},{"key":"R7-20260821","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/0971-9784.173042","article-title":"Left ventricular pseudoaneurysm versus aneurysm a diagnosis dilemma.","volume":"19","author":"Bisoyi","year":"2016","journal-title":"Ann Card Anaesth"},{"key":"R8-20260821","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/qjmed\/hcv224","article-title":"Medical treatment of left ventricular pseudoaneurysms.","volume":"109","author":"Webb","year":"2016","journal-title":"QJM"},{"key":"R9-20260821","first-page":"569","article-title":"Left ventricular pseudoaneurysm complicated with very late rupture 5 years after myocardial infarction.","volume":"1","author":"Al Saidi","year":"2019","journal-title":"JAC Case Rep"},{"key":"R10-20260821","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1136\/hrt.2004.042135","article-title":"Percutaneous device closure of a pseudoaneurysm of the left ventricular wall.","volume":"90","author":"Clift","year":"2004","journal-title":"Heart"},{"key":"R11-20260821","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1253\/circj.66.705","article-title":"Long-term usefulness of percutaneous intrapericardial fibrin-glue fixation therapy for oozing type of left ventricular free wall rupture: a case report.","volume":"66","author":"Joho","year":"2002","journal-title":"Circ J"},{"key":"R12-20260821","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCINTERVENTIONS.111.962464","article-title":"Percutaneous closure of left ventricular pseudoaneurysm.","volume":"4","author":"Dudiy","year":"2011","journal-title":"Circ Cardiovasc Interve"},{"key":"R13-20260821","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jcin.2017.06.033","article-title":"Percutaneous closure of left ventricular pseudoaneursym with septal occluder device and coils: a multimodality imaging approach.","volume":"10","author":"Yudi","year":"2017","journal-title":"JACC Cardiovasc Interv"}],"container-title":["Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/HPC.0000000000000424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:26:22Z","timestamp":1787318782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/HPC.0000000000000424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/hpc.0000000000000424","relation":{},"ISSN":["1535-2811"],"issn-type":[{"value":"1535-2811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}