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Being typically mild, it is falsely perceived as a minor problem, particularly in the elderly with multimorbidity, so that it often remains unrecognized and untreated. Indeed, mounting evidence indicates that anemia in the elderly (AE) is independently associated with disability and other major negative outcomes, including mortality. AE is generally multifactorial, but initial studies suggested that etiology remains unexplained in near one\u2010third of cases. This proportion is consistently declining due to recent advances highlighting the role of several conditions including clonal hematopoiesis, \u201cinflammaging,\u201d correctable androgen deficiency in men, and under\u2010recognized iron deficiency. Starting from a real\u2010world case vignette illustrating a paradigmatic example of anemia in an elderly patient with multimorbidity, we review the main clinical and pathophysiological aspect of AE, giving some practical insights into how to manage similar cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/hs9.0000000000000040","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T13:36:54Z","timestamp":1524577014000},"source":"Crossref","is-referenced-by-count":109,"title":["Anemia in the Elderly"],"prefix":"10.1002","volume":"2","author":[{"given":"Domenico","family":"Girelli","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Internal Medicine University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Internal Medicine University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Camaschella","sequence":"additional","affiliation":[{"name":"Division of Genetics and Cell Biology San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61460-4"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Nutritional anaemias. 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