{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:00:21Z","timestamp":1777946421849,"version":"3.51.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2020-0236"],"award-info":[{"award-number":["6-2020-0236"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2020-0195"],"award-info":[{"award-number":["6-2020-0195"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>Uveal effusion syndrome (UES) is a rare eye condition characterized by fluid accumulation in the uveal layer. We investigated its clinical characteristics and treatment modalities and their association with long-term visual outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This retrospective cohort study included patients with UES treated at two tertiary hospitals between November 2005 and June 2023. Clinical characteristics and treatment outcomes by modality were compared between nanophthalmic Type 1 UES (UES-1) and non-nanophthalmic Type 2 UES (UES-2), and between initial and final visits. Logistic regression analysis was used to identify factors associated with vision loss.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Twenty-three eyes were included (UES-1, n = 10; UES-2, n = 13). Retinal pigment epithelium mottling was significantly more common in UES-1 than in UES-2 (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.043); no other between-group differences were observed. Post-treatment, in UES-1, best-corrected visual acuity (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.028) and central macular thickness (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.046) significantly decreased; in UES-2, best-corrected visual acuity significantly improved (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.021), and subfoveal choroidal thickness (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.048), central subretinal fluid height (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.011), and central macular thickness (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.010) significantly decreased. UES-2 was associated with a lower risk of vision loss (odds ratio, 0.024; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.044). No other associated factors were identified.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The UES type was the sole independent prognostic factor for vision loss, whereas treatment modalities had no significant impact on visual outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iae.0000000000004019","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T21:01:23Z","timestamp":1702933283000},"page":"642-651","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["CLINICAL CHARACTERISTICS, TREATMENT MODALITIES, AND THEIR ASSOCIATION WITH LONG-TERM VISUAL OUTCOMES IN UVEAL EFFUSION SYNDROME"],"prefix":"10.1097","volume":"44","author":[{"given":"Eun Young","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Gangnam Severance Hospital, Seoul, Republic of Korea; and"},{"name":"Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gangnam Severance Hospital, Seoul, Republic of Korea; and"},{"name":"Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsuk","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gangnam Severance Hospital, Seoul, Republic of Korea; and"},{"name":"Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOUNG JE","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gangnam Severance Hospital, Seoul, Republic of Korea; and"},{"name":"Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6959","authenticated-orcid":false,"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gangnam Severance Hospital, Seoul, Republic of Korea; and"},{"name":"Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20250605","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1177\/1120672120969369","article-title":"A prospective, population-based, surveillance (BOSU) study of uveal effusion syndrome in the UK","volume":"31","author":"Sharma","year":"2021","journal-title":"Eur J Ophthalmol"},{"issue":"Pt 2","key":"R2-20250605","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/eye.1990.48","article-title":"The uveal effusion syndrome and trans-scleral flow","volume":"4","author":"Forrester","year":"1990","journal-title":"Eye (Lond)"},{"key":"R3-20250605","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archopht.1991.01080070129050","article-title":"Abnormal scleral collagen in nanophthalmos. 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