{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:39:52Z","timestamp":1780411192185,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the progression of atrophy in pathologic myopia eyes with prior retinal inflammatory lesions consistent with punctate inner choroidopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Retrospective case series of 21 eyes with pathologic myopia and resolved retinal inflammatory lesions compared with 26 noninflamed controls (14 fellow eyes; 12 external myopic eyes with pre-existing patchy atrophy). The primary outcome was annual atrophy-area change (mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year) on multimodal imaging. Secondary outcomes included incident\/enlarging atrophy, multifocal versus unifocal appearance, and META-PM category progression. Group comparisons used Welch\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      tests and Fisher exact tests; an age-adjusted linear regression examined independent associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Over 5.2 \u00b1 3.2 years in inflamed eyes and 5.3 \u00b1 2.4 years in controls, patchy atrophy progressed faster with inflammation (0.76 \u00b1 0.67 vs. 0.38 \u00b1 0.47 mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). Among eyes starting in myopic macular degeneration Category 1 to 2, incident atrophy occurred in 14 of 14 (100%) inflamed versus 4 of 11 (36.4%) controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Overall atrophy activity (new or enlarging) was 21 of 21 (100%) in inflamed eyes versus 19 of 26 (73.1%) controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Multifocal atrophy was more frequent with inflammation (15\/21, 71.4%) than in controls (6\/26, 23.1%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). In age-adjusted regression, inflammation remained independently associated with faster atrophy expansion (\u03b2 = 0.41 mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year; 95% CI, 0.04\u20130.78;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In pathologic myopia, prior retinal inflammation is independently associated with more frequent multifocal involvement, higher risk of incident atrophy, and a substantially faster atrophy-expansion. Beyond mechanical factors, inflammation seems to be a key driver of atrophic progression in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/iae.0000000000004697","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:00:30Z","timestamp":1771347630000},"page":"465-476","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["ROLE OF INFLAMMATION IN ATROPHY DEVELOPMENT AND PROGRESSION IN PATHOLOGIC MYOPIA"],"prefix":"10.1097","volume":"46","author":[{"given":"Noa","family":"Gilead","sequence":"first","affiliation":[{"name":"Singapore National Eye Centre, Singapore;"},{"name":"Singapore Eye Research Institute, Singapore; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeat","family":"Chong","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore;"},{"name":"Singapore Eye Research Institute, Singapore; 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