{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:06:02Z","timestamp":1793037962427,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report anatomical and functional outcomes of epiretinal proliferation (EP) embedding without internal limiting membrane peeling for lamellar macular holes (LMHs) with EP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective interventional case series involved patients with idiopathic LMHs and EP who underwent pars plana vitrectomy using the EP-embedding technique without internal limiting membrane peeling. The EP was peeled centripetally, left connected to the LMH edge, and embedded into the retinal cleavage plane. 20% sulfur hexafluoride gas tamponade was applied. After surgery, patients were recommended to avoid lying face-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen eyes of 15 patients were included, and the mean follow-up was 12 \u00b1 8 months. Lamellar macular hole closure was achieved in 100% of cases. Best-corrected visual acuity and central retinal thickness showed significant postoperative improvement, from 0.31 \u00b1 0.20 logMAR (20\/40 Snellen) and 156.5 \u00b1 40.7\n                      <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                      m preoperatively to 0.10 \u00b1 0.12 logMAR (20\/25 Snellen) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002) and 221.5 \u00b1 46.5\n                      <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                      m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), respectively. Ellipsoid zone (EZ) and external limiting membrane restoration rates were 50% and 100%, respectively. No cases of full-thickness macular hole formation, LMH recurrence, or major complications were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EP-embedding without internal limiting membrane peeling yields favorable anatomical and functional outcomes in LMHs with EP and supports the nontractional pathophysiology of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/iae.0000000000004792","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T22:00:11Z","timestamp":1770760811000},"page":"1024-1030","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["EPIRETINAL PROLIFERATION EMBEDDING WITHOUT INTERNAL LIMITING MEMBRANE PEELING FOR LAMELLAR MACULAR HOLE"],"prefix":"10.1097","volume":"46","author":[{"given":"Ginevra G.","family":"Adamo","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy;"},{"name":"Sant'Anna University Hospital, Ferrara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy;"},{"name":"Sant'Anna University Hospital, Ferrara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro M.","family":"Talli","sequence":"additional","affiliation":[{"name":"Sant'Anna University Hospital, Ferrara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Mondin","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cartabellotta","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Giannaccare","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mura","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, Ferrara, Italy;"},{"name":"Sant'Anna University Hospital, Ferrara, Italy;"},{"name":"King Khaled Eye Specialist Hospital, Riyadh, Saudi 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