{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:50:48Z","timestamp":1791582648497,"version":"4.3.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the foveal microvascular structure in children with a history of hypoxic ischemic encephalopathy (HIE) compared with healthy controls<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective cross-sectional comparative study included 46 eyes of 23 children with HIE and 40 eyes of 20 age-matched healthy controls. The children were grouped as follows: Group 1: HIE Stage I (n=28 eyes); Group 2: HIE Stage II-III (n=18 eyes); Group 3: healthy age-matched controls (n=40 eyes). Patients were also subgrouped based on fundus appearance within the first week of life as follows: Group A: eyes without any retinal hemorrhages (RHs) (n=13 eyes); Group B: eyes with widespread peripheral RHs sparing the macula (n=28 eyes); Group C: eyes with widespread peripheral RHs with macular involvement (n=5 eyes); Group D: healthy controls (n=40 eyes). All children underwent optical coherence tomography angiography (OCTA)(Solix Visionix). FAZ area, foveal vessel densities and central foveal thickness (CFT) were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Foveal vessel density of the superficial capillary plexus (VD-SCP) and CFT were significantly higher in Group 2 compared with Group 1 (all p&lt;0.05). Significantly smaller FAZ area was noted in Group 2 (0.19\u00b10.09 mm\n                      <jats:sup>2<\/jats:sup>\n                      ) compared with Group 1 (0.28\u00b10.10 mm\n                      <jats:sup>2<\/jats:sup>\n                      ) and 3 (0.26\u00b10.09 mm\n                      <jats:sup>2<\/jats:sup>\n                      )(all p&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>HIE may lead to persistent alterations in foveal microvasculature. OCTA may serve as a non-invasive biomarker for detecting long-term retinal microvascular sequelae in children with a history of perinatal asphyxia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/iae.0000000000004974","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:00:10Z","timestamp":1791579610000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Foveal Microvascular Alterations in Children With Hypoxic-Ischemic Encephalopathy: An OCT Angiography Study"],"prefix":"10.1097","author":[{"given":"Zeynep","family":"Seymen","sequence":"first","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim","family":"Polat","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayri Ferhat","family":"Budak","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"Zeybek Aydo\u011fan","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fclya","family":"G\u00fcngel","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/IAE.0000000000004974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:00:10Z","timestamp":1791579610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/IAE.0000000000004974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1097\/iae.0000000000004974","relation":{},"ISSN":["0275-004X","1539-2864"],"issn-type":[{"value":"0275-004X","type":"print"},{"value":"1539-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}