{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:43:20Z","timestamp":1790642600678,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/iae.0b013e3181f9c242","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T01:30:11Z","timestamp":1296783011000},"page":"1207-1214","source":"Crossref","is-referenced-by-count":126,"title":["INTRAVITREAL INJECTION OF AUTOLOGOUS BONE MARROW\u2013DERIVED MONONUCLEAR CELLS FOR HEREDITARY RETINAL DYSTROPHY"],"prefix":"10.1097","volume":"31","author":[{"given":"Rubens C","family":"Siqueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Messias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C","family":"Voltarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid U","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20210130","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa.","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"R2-28-20210130","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/emboj\/21.5.857","article-title":"On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention.","volume":"21","author":"Farrar","year":"2002","journal-title":"EMBO J"},{"key":"R3-28-20210130","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.05-1443","article-title":"Prevalence of disease-causing mutations in families with autosomal dominant retinitis pigmentosa: a screen of known genes in 200 families.","volume":"47","author":"Sullivan","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R4-28-20210130","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJM199011083231903","article-title":"Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.","volume":"323","author":"Dryja","year":"1990","journal-title":"N Engl J Med"},{"key":"R5-28-20210130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/ng1295-468","article-title":"Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase.","volume":"11","author":"Huang","year":"1995","journal-title":"Nat Genet"},{"key":"R6-28-20210130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0420.2006.00820.x","article-title":"Autosomal dominant retinitis pigmentosa in Norway: a 20-year clinical follow-up study with molecular genetic analysis. Two novel rhodopsin mutations: 1003delG and I179F.","volume":"85","author":"Grondahl","year":"2007","journal-title":"Acta Ophthalmol Scand"},{"key":"R7-28-20210130","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/354478a0","article-title":"A three-base-pair deletion in the peripherin-RDS gene in one form of retinitis pigmentosa.","volume":"354","author":"Farrar","year":"1991","journal-title":"Nature"},{"key":"R8-28-20210130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/13816810802626399","article-title":"RPE65: role in the visual cycle, human retinal disease, and gene therapy.","volume":"30","author":"Cai","year":"2009","journal-title":"Ophthalmic Genet"},{"key":"R9-28-20210130","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tig.2009.02.003","article-title":"Prospects for retinal gene replacement therapy.","volume":"25","author":"Smith","year":"2009","journal-title":"Trends Genet"},{"key":"R10-28-20210130","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/77068","article-title":"Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.","volume":"25","author":"Ali","year":"2000","journal-title":"Nat Genet"},{"key":"R11-28-20210130","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/mt.2008.301","article-title":"Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.","volume":"17","author":"Chadderton","year":"2009","journal-title":"Mol Ther"},{"key":"R12-28-20210130","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1167\/iovs.06-1501","article-title":"Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer.","volume":"48","author":"Tomita","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R13-28-20210130","doi-asserted-by":"crossref","first-page":"12584","DOI":"10.1073\/pnas.221364198","article-title":"Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.","volume":"98","author":"Vollrath","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R14-28-20210130","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ophtha.2006.10.028","article-title":"Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.","volume":"114","author":"Jacobson","year":"2007","journal-title":"Ophthalmology"},{"key":"R15-28-20210130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0501-92","article-title":"Gene therapy restores vision in a canine model of childhood blindness.","volume":"28","author":"Acland","year":"2001","journal-title":"Nat Genet"},{"key":"R16-28-20210130","first-page":"2724","article-title":"Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd\/rd mouse.","volume":"40","author":"Frasson","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R17-28-20210130","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1006\/mthe.2001.0498","article-title":"Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.","volume":"4","author":"McGee Sanftner","year":"2001","journal-title":"Mol Ther"},{"key":"R18-28-20210130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/347083a0","article-title":"Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor.","volume":"347","author":"Faktorovich","year":"1990","journal-title":"Nature"},{"key":"R19-28-20210130","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/13508","article-title":"Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse.","volume":"5","author":"Frasson","year":"1999","journal-title":"Nat Med"},{"key":"R20-28-20210130","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1167\/iovs.06-1404","article-title":"Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.","volume":"48","author":"Morimoto","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R21-28-20210130","doi-asserted-by":"crossref","first-page":"9282","DOI":"10.1523\/JNEUROSCI.18-22-09282.1998","article-title":"Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse.","volume":"18","author":"Cayouette","year":"1998","journal-title":"J Neurosci"},{"key":"R22-28-20210130","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1073\/pnas.0600236103","article-title":"Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants.","volume":"103","author":"Sieving","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-28-20210130","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1073\/pnas.96.6.3126","article-title":"Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats.","volume":"96","author":"Uteza","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R24-28-20210130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1634\/stemcells.2005-0059","article-title":"Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors.","volume":"24","author":"Meyer","year":"2006","journal-title":"Stem Cells"},{"key":"R25-28-20210130","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/IAE.0b013e31817d8c1b","article-title":"The potential of pluripotent cells in vitreoretinal diseases.","volume":"28","author":"Spaide","year":"2008","journal-title":"Retina"},{"key":"R26-28-20210130","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00417-006-0382-7","article-title":"Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse.","volume":"245","author":"Arnhold","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R27-28-20210130","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1172\/JCI200421686","article-title":"Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.","volume":"114","author":"Otani","year":"2004","journal-title":"J Clin Invest"},{"key":"R28-28-20210130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0420.2007.00987.x","article-title":"Intravitreal autologous bone marrow-derived mononuclear cell transplantation: a feasibility report.","volume":"86","author":"Jonas","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"R29-28-20210130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10633-008-9155-4","article-title":"ISCEV Standard for full-field clinical electroretinography (2008 update).","volume":"118","author":"Marmor","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"R30-28-20210130","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.","volume":"97","author":"Boyum","year":"1968","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"R31-28-20210130","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3928\/1081-597X-19970701-16","article-title":"Proper method for calculating average visual acuity.","volume":"13","author":"Holladay","year":"1997","journal-title":"J Refract Surg"},{"key":"R33-28-20210130","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1182\/blood-2004-02-0612","article-title":"A role for bone marrow-derived cells in the vasculature of noninjured CNS.","volume":"105","author":"Galimi","year":"2005","journal-title":"Blood"},{"key":"R34-28-20210130","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1182\/blood-2003-09-3012","article-title":"Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina.","volume":"103","author":"Dorrell","year":"2004","journal-title":"Blood"},{"key":"R35-28-20210130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1634\/stemcells.20-4-279","article-title":"Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina.","volume":"20","author":"Tomita","year":"2002","journal-title":"Stem Cells"}],"container-title":["Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006982-201106000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:57:33Z","timestamp":1786042653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006982-201106000-00028"}},"subtitle":["A Phase I Trial"],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/iae.0b013e3181f9c242","relation":{},"ISSN":["0275-004X"],"issn-type":[{"value":"0275-004X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}