{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:53:09Z","timestamp":1791960789421,"version":"4.3.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To report a case of bilateral recurrent posterior uveitis caused by human herpes virus-6 (HHV-6) in a human immunodeficiency virus\u2013positive individual.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Comprehensive ophthalmic examination, including imaging with optical coherence tomography, fluorescein and indocyanine green angiography, and adequate laboratory tests were performed. A human immunodeficiency virus\u2013positive patient without any AIDS defining condition, with a history of recurrent bilateral posterior uveitis referred to us with the diagnosis of retinal detachment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Vitreous polymerase chain reaction detected an aberrant band for herpes viruses, which proved to be human herpes virus-6 by repeated polymerase chain reactions. Serum antibodies titer was positive for human herpes virus-6. The patient responded well to antiviral therapy with valacyclovir.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>This is the first case of human herpes virus-6\u2013related bilateral posterior uveitis in a human immunodeficiency virus\u2013positive individual without clinical manifestations of AIDS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/icb.0b013e3182595705","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T07:18:21Z","timestamp":1338448701000},"page":"131-133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["HUMAN HERPES VIRUS-6 AS A CAUSE OF RECURRENT POSTERIOR UVEITIS IN A HIV-POSITIVE PATIENT"],"prefix":"10.1097","volume":"7","author":[{"given":"Panagiotis","family":"Malamos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Maselos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Andrianopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Georgalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Chryssos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos N.","family":"Markomichelakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240721","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1128\/CMR.12.3.367","article-title":"Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate.","volume":"12","author":"Doniger","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"R2-4-20240721","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1096-9071(199608)49:4<289::AID-JMV6>3.0.CO;2-#","article-title":". 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Identification of new pathogens in the intraocular fluid of patients with uveitis.","volume":"150","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"R6-4-20240721","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1001\/archopht.125.10.1426","article-title":". Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis.","volume":"125","author":"Sugita","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"R7-4-20240721","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1016\/j.jinf.2006.12.012","article-title":". Acute bilateral uveitis associated with an active human herpesvirus-6 infection.","volume":"54","author":"Maslin","year":"2007","journal-title":"J Infect"},{"key":"R8-4-20240721","first-page":"561","article-title":"Unilateral uveitis with HHV6-positive polymerase chain reaction in aqueous humor for an etanercept-treated woman: a case report.","volume":"33","author":"Glatre","year":"2010","journal-title":"J Fr Ophtalmol"}],"container-title":["RETINAL Cases &amp; Brief Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01271216-201300720-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T08:00:20Z","timestamp":1721548820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01271216-201300720-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/icb.0b013e3182595705","relation":{},"ISSN":["1935-1089"],"issn-type":[{"value":"1935-1089","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}