{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:10:18Z","timestamp":1744189818631},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To report a case of subretinal deposits, paramacular atrophy, and pigmentary retinopathy associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Retrospective review of medical records.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A 45-year-old white woman presented with progressive deterioration of vision and dark adaptation over several years. She had a background of an undiagnosed neurodegenerative disorder, including sensorineural hearing loss, cognitive disturbance, and peripheral neuropathy. On examination, subretinal deposits were visible along the superotemporal arcades. A diagnosis of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes was confirmed by genetic testing (<jats:italic toggle=\"yes\">A3243G<\/jats:italic> gene mutation). Four years later, she had developed paramacular atrophy and pigmentary retinopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes may be associated with paramacular atrophy and pigmentary retinopathy. Autofluorescent changes may precede these signs and can help distinguish this condition from Stargardt disease\u2013fundus flavimaculatus. As far as we are aware, this is the first report of fundus autofluorescence imaging and optical coherence tomography in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes\u2013associated retinopathy. Subretinal deposit may be an early sign.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/icb.0b013e318271ee90","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T06:48:49Z","timestamp":1351666129000},"page":"14-18","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["SUBRETINAL DEPOSITS, PARAMACULAR ATROPHY AND PIGMENTARY RETINOPATHY IN MITOCHONDRIAL ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES"],"prefix":"10.1097","volume":"7","author":[{"given":"Adrian T.","family":"Fung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Engelbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey G.","family":"Odel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Yannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20240721","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00417-002-0555-y","article-title":"Pigmentary retinopathy in patients with the MELAS mutation 3243A-G in mitochondrial DNA.","volume":"240","author":"Latvala","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R2-4-20240721","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00019052-200302000-00005","article-title":"Neuro-ophthalmology of mitochondrial diseases.","volume":"16","author":"Biousse","year":"2003","journal-title":"Curr Opin Neurol"},{"key":"R3-4-20240721","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0002-9394(99)00057-4","article-title":"Mitochondrial maculopathy: geographic atrophy of the macula in the MELAS associated A to G 3243 mitochondrial DNA point mutation.","volume":"128","author":"Latkany","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"R4-4-20240721","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0161-6420(99)90244-0","article-title":". 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