{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:10:59Z","timestamp":1764936659880},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"abstract":"\n Purpose:<\/jats:title>\n To assess ocular and orbital structure by ocular echography and magnetic resonance imaging, fluoroangiography, indocyanine green angiography, and optical coherence tomography before and after therapy with rituximab (Mabthera) and chlorambucil in a patient with concurrent intraorbital and intraocular lymphoma and diplopia.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A 69-year-old man referred blurred vision and proptosis in his left eye associated with diplopia. Best-corrected visual acuity was 0.3 logarithm of the minimum angle of resolution in the left eye and 0.02 logarithm of the minimum angle of resolution in the right eye. Ocular echography and magnetic resonance imaging revealed the presence of concurrent orbital and intraocular tumor, and a B-cell lymphocytic lymphoma was diagnosed by incisional biopsy. The patient was treated with the oral alkylating agent chlorambucil and with intravenous infusions of the monoclonal anti-CD20 antibody rituximab (Mabthera) and evaluated with visual acuity, echography, fluoroangiography, indocyanine green angiography, and magnetic resonance imaging.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n After combined immunochemotherapy with rituximab\/chlorambucil, the patient showed in the left eye a significant improvement of visual acuity (0.1 logarithm of the minimum angle of resolution) and a disappearance of diplopia at the end of follow-up.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In this case report, combined systemic therapy with chlorambucil and rituximab was effective to reduce and control orbital and intraocular lymphoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/icb.0b013e31828eef88","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T13:33:59Z","timestamp":1366724039000},"page":"267-270","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["SECONDARY ORBITAL AND INTRAOCULAR LYMPHOMA TREATED WITH IMMUNOCHEMOTHERAPY"],"prefix":"10.1097","volume":"7","author":[{"given":"Gustavo","family":"Savino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Petroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Balia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela G.","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Battendieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"d\u2019Al\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Balestrazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-22-20240721","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1600-0420.2004.00354.x","article-title":". Co-existence of intraocular and orbital lymphoma.","volume":"82","author":"Neudorfer","year":"2004","journal-title":"Acta Ophthalmol Scand"},{"key":"R2-22-20240721","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hon.741","article-title":". Ophthalmologic and intraocular non-Hodgkins lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors.","volume":"22","author":"Meunier","year":"2004","journal-title":"Hematol Oncol"},{"key":"R3-22-20240721","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1006242116122","article-title":"Classification, pathogenesis and molecular pathology of CNS lymphoma.","volume":"43","author":"Paulus","year":"1999","journal-title":"J Neurooncol"},{"key":"R4-22-20240721","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/ICU.0b013e3282be8fbb","article-title":"Lymphoproliferative disease of the orbit.","volume":"18","author":"Bernardini","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"key":"R5-22-20240721","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1182\/blood-2006-02-005017","article-title":"Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options.","volume":"108","author":"Decaudin","year":"2006","journal-title":"Blood"},{"key":"R6-22-20240721","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0360-3016(94)00416-1","article-title":"Radiation therapy for primary orbital lymphoma.","volume":"31","author":"Chao","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R7-22-20240721","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/cncr.11317","article-title":". Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy.","volume":"97","author":"Wenzel","year":"2003","journal-title":"Cancer"},{"key":"R8-22-20240721","first-page":"1578","article-title":". Rituximab in patients with mucosal-associated lymphoid tissue-type lymphoma of the ocular adnexa.","volume":"90","author":"Ferreri","year":"2005","journal-title":"Haematologica"}],"container-title":["RETINAL Cases & Brief Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01271216-201300730-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T08:01:31Z","timestamp":1721548891000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01271216-201300730-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/icb.0b013e31828eef88","relation":{},"ISSN":["1935-1089"],"issn-type":[{"value":"1935-1089","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}