{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:08:18Z","timestamp":1745503698757},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>Previous work has suggested that Descemet membrane (DM) folds arise in response to corneal swelling. However, their origin has not been closely explored. In this study, we used optical coherence tomography to evaluate whether DM folds arise secondary to folds in the middle stroma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Serial optical coherence tomography images of donor cornea pairs in deionized water were taken for each of the following corneal manipulations: 1) untreated, 2) DM and the endothelium removed, 3) excised in the region of the deep middle\/posterior stroma, and 4) excised in the middle stroma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>For intact corneas, increasing duration in deionized water was marked by a progressive increase in corneal thickness and number of folds along the posterior surface. With DM and the endothelium removed, a similar phenomenon was observed. In the third set of corneas, the plane of resection created a structural separation in the region of the deep middle\/posterior stroma. Folds were seen originating anterior to the resection plane. For corneas with the posterior and part of the middle stroma removed, the typical folds on the posterior surface as seen in the previous conditions were not observed. Instead, less numerous and smaller irregularities of the posterior surface of the resection plane were present.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Folds in DM associated with corneal edema originate in the middle and posterior stroma and are secondarily transmitted into DM. On the basis of the stromal origin of these anatomic changes, \u201cstromal folds\u201d should be considered a more accurate term to replace \u201cDescemet membrane folds.\u201d<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ico.0000000000001908","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T03:19:51Z","timestamp":1552447191000},"page":"754-757","source":"Crossref","is-referenced-by-count":4,"title":["Optical Coherence Tomography Assessment of the Cornea During Corneal Swelling: Should the Term \u201cDescemet Membrane Folds\u201d Be Reconsidered?"],"prefix":"10.1097","volume":"38","author":[{"given":"Anvesh","family":"Annadanam","sequence":"first","affiliation":[{"name":"Cornea, Cataract, and External Disease Division, Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Stoeger","sequence":"additional","affiliation":[{"name":"Lions VisionGift, Portland, OR."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Lions VisionGift, Portland, OR."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Hikes","sequence":"additional","affiliation":[{"name":"Lions VisionGift, Portland, OR."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert S.","family":"Jun","sequence":"additional","affiliation":[{"name":"Cornea, Cataract, and External Disease Division, Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"R1-20230912","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/IMCRJ.S84865","article-title":"A case of traumatic corneal stromal edema with decreased endothelial cell density","volume":"8","author":"Kim","year":"2015","journal-title":"Int Med Case Rep J."},{"key":"R2-20230912","doi-asserted-by":"crossref","first-page":"e170669","DOI":"10.1001\/jamaophthalmol.2017.0669","article-title":"Folds in Descemet membrane associated with forceps-induced injury","volume":"135","author":"Yadav","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"R3-20230912","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1364\/JOSA.66.000342","article-title":"On corneal transparency and its loss with swelling","volume":"66","author":"Farrell","year":"1976","journal-title":"J Opt Soc Am."},{"key":"R4-20230912","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-5320(77)90009-0","article-title":"Striations of light scattering in the corneal stroma","volume":"61","author":"Gallagher","year":"1977","journal-title":"J Ultrastruct Res."},{"key":"R5-20230912","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3928\/1081-597X-19920501-09","article-title":"A comparison of corneal stromal edema induced from the anterior or the posterior surface","volume":"8","author":"Cristol","year":"1992","journal-title":"Refract Corneal Surg."},{"key":"R6-20230912","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/02713688109019986","article-title":"Non-uniform swelling properties of the corneal stroma","volume":"1","author":"Lee","year":"1981","journal-title":"Curr Eye Res."},{"key":"R7-20230912","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/bjo.85.4.437","article-title":"The specific architecture of the anterior stroma accounts for maintenance of corneal curvature","volume":"85","author":"M\u00fcller","year":"2001","journal-title":"Br J Ophthalmol."},{"key":"R8-20230912","first-page":"e3847","article-title":"Corneal donor tissue preparation for endothelial keratoplasty","author":"Woodward","year":"2012","journal-title":"J Vis Exp."},{"key":"R9-20230912","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/bs.pmbts.2015.04.001","article-title":"Overview of the cornea: structure, function, and development","volume":"134","author":"Shtein","year":"2015","journal-title":"Prog Mol Biol Transl Sci."},{"key":"R10-20230912","first-page":"2244","article-title":"The three-dimensional organization of collagen fibrils in the human cornea and sclera","volume":"32","author":"Komai","year":"1991","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"R11-20230912","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00003226-199809000-00012","article-title":"Interlacing and cross-angle distribution of collagen lamellae in the human cornea","volume":"17","author":"Radner","year":"1998","journal-title":"Cornea"},{"key":"R12-20230912","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0021-9290(86)90135-1","article-title":"The mechanical properties of the rabbit and human cornea","volume":"19","author":"Mallinger","year":"1986","journal-title":"J Biomech."}],"container-title":["Cornea"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00003226-201906000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T19:35:02Z","timestamp":1694547302000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003226-201906000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/ico.0000000000001908","relation":{},"ISSN":["0277-3740"],"issn-type":[{"value":"0277-3740","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3,14]]}}}