{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:23:14Z","timestamp":1770445394466,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the relationship between corneal sensitivity (CS), vision-related quality of life, ocular surface symptoms, and clinical severity in patients with Parkinson's disease (PwP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective observational cohort study. CS was measured using a noncontact esthesiometer. Vision-related quality of life and ocular surface symptoms were assessed with the NEI VFQ-25 and OSDI questionnaires. Parkinson's disease severity was graded with the Hoehn and Yahr (HY) scale. Associations were analyzed using Pearson correlation and ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 356 eyes from 178 PwP were included. Mean age was 62.77 \u00b1 11.34 years, and 51.4% were male. Mean CS was 6.47 \u00b1 2.24 mBar, NEI VFQ-25 score was 67.11 \u00b1 9.35, and OSDI score was 25.17 \u00b1 18.19. CS was significantly associated with the NEI VFQ-25 composite score (r = 0.449,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) but not with the OSDI score (r = 0.122,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.141). NEI VFQ-25 and OSDI scores showed moderate correlation (r = 0.477,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). CS also correlated with general vision, near vision, distance vision, mental health, and peripheral vision subscales (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05). CS varied across HY stages (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), with stages 3 to 4 demonstrating significantly reduced sensitivity compared with stages 1 to 2 (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CS correlates with vision-related quality of life but not directly with ocular surface symptoms in PwP. Its progressive reduction with advancing HY stages suggests potential as a surrogate marker of disease severity. CS measurements may complement quality-of-life assessments and aid in the early detection of ocular surface compromise in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/ico.0000000000004100","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T15:00:28Z","timestamp":1770390028000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Corneal Sensitivity With Vision-Related Quality of Life, Ocular Surface Symptoms, and Clinical Severity in Parkinson's Disease"],"prefix":"10.1097","author":[{"given":"Azyadeh","family":"Camacho-Ordonez","sequence":"first","affiliation":[{"name":"Department of Anterior Segment. Instituto de Oftalmolog\u00eda Fundaci\u00f3n Conde de Valenciana, Mexico City, Mexico;"},{"name":"Department of Neuro-ophthalmology. Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Navarrete-Azuara","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery. Instituto de Oftalmolog\u00eda Fundaci\u00f3n Conde de Valenciana IAP, Mexico City, Mexico; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3417-256X","authenticated-orcid":false,"given":"Guillermo Raul","family":"Vera-Duarte","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery. Instituto de Oftalmolog\u00eda Fundaci\u00f3n Conde de Valenciana IAP, Mexico City, Mexico; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lourdes","family":"Guerra-Anzaldo","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Neurodegenerative Diseases. Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel Geovanny","family":"Alcocer-Salas","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Neurodegenerative Diseases. Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayela","family":"Rodr\u00edguez-Violante","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Neurodegenerative Diseases. Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Cervantes-Arriaga","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Neurodegenerative Diseases. 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