{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:03:17Z","timestamp":1786755797351,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1097\/ico.0b013e3181d82f5e","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T09:32:15Z","timestamp":1281173535000},"page":"1241-1246","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Trials of Therapeutic Ocular Surface Medium for Moderate to Severe Dry Eye"],"prefix":"10.1097","volume":"29","author":[{"given":"Stephanie L","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie T","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John KG","family":"Dart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210204","first-page":"221","article-title":"Report of the National Eye Institute\/Industry Workshop on clinical trials in dry eyes.","volume":"21","author":"Lemp","year":"1995","journal-title":"CLAO J"},{"key":"R2-6-20210204","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00006324-200007000-00010","article-title":"Prevalence of dry eye subtypes in clinical optometry practice.","volume":"77","author":"Albietz","year":"2000","journal-title":"Optom Vis Sci"},{"key":"R3-6-20210204","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9394(14)71688-5","article-title":"Prevalence of dry eye among the elderly.","volume":"124","author":"Schein","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"R4-6-20210204","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00003226-200108000-00011","article-title":"Characterization of ocular surface symptoms from optometric practices in North America.","volume":"20","author":"Begley","year":"2001","journal-title":"Cornea"},{"key":"R5-6-20210204","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0161-6420(85)33967-2","article-title":"Staging of conjunctival squamous metaplasia by impression cytology.","volume":"92","author":"Tseng","year":"1985","journal-title":"Ophthalmology"},{"issue":"4","key":"R6-6-20210204","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00004397-200010000-00009","article-title":"Serum application for the treatment of ocular surface disorders.","volume":"40","author":"Tsubota","year":"2000","journal-title":"Int Ophthalmol Clin"},{"key":"R7-6-20210204","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1167\/iovs.08-1991","article-title":"Nuture and nourish - development of a nutrient ocular lubricant.","volume":"50","author":"Liu","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R8-6-20210204","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.bmt.1703862","article-title":"Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease.","volume":"31","author":"Ogawa","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"R9-6-20210204","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/00003226-200111000-00005","article-title":"Controlled study of the use of autologous serum in dry eye patients.","volume":"20","author":"Tananuvat","year":"2001","journal-title":"Cornea"},{"key":"R10-6-20210204","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/bjo.2003.026211","article-title":"Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease.","volume":"88","author":"Noble","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"R11-6-20210204","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/bjo.83.4.390","article-title":"Treatment of dry eye by autologous serum application in Sjogrens syndrome.","volume":"83","author":"Tsubota","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"R12-6-20210204","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1136\/bjo.85.10.1188","article-title":"Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies.","volume":"85","author":"Poon","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"R13-6-20210204","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/art.1780270415","article-title":"Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca.","volume":"27","author":"Fox","year":"1984","journal-title":"Arthritis Rheum"},{"key":"R14-6-20210204","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0002-9394(01)01230-2","article-title":"Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells.","volume":"132","author":"Geerling","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"R16-6-20210204","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogrens syndrome: a revised version of the European criteria proposed by the American-European Consensus Group.","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"R18-6-20210204","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00003226-200009000-00010","article-title":"Changing concepts in the diagnosis and management of blepharitis.","volume":"19","author":"McCulley","year":"2000","journal-title":"Cornea"},{"key":"R19-6-20210204","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0161-6420(82)34669-2","article-title":"Classification of chronic blepharitis.","volume":"89","author":"McCulley","year":"1982","journal-title":"Ophthalmology"},{"key":"R20-6-20210204","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00003226-199603000-00002","article-title":"Model for ocular tear film function.","volume":"15","author":"Mathers","year":"1996","journal-title":"Cornea"},{"key":"R21-6-20210204","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0002-9394(14)71690-3","article-title":"Rose bengal staining and cytologic characteristics associated with lipid tear deficiency.","volume":"124","author":"Lee","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"R22-6-20210204","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003226-199801000-00007","article-title":"Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irriation.","volume":"17","author":"Pflugfelder","year":"1998","journal-title":"Cornea"},{"key":"R23-6-20210204","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archopht.118.12.1632","article-title":"Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease.","volume":"118","author":"Marci","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"R24-6-20210204","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0891-5520(20)30481-5","article-title":"Blepharitis.","volume":"6","author":"Raskin","year":"1992","journal-title":"Infect Dis Clin North Am"},{"key":"R25-6-20210204","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ajo.2004.08.040","article-title":"The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study.","volume":"139","author":"Kojima","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"R26-6-20210204","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/bjo.83.10.1121","article-title":"Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w\/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome.","volume":"83","author":"Condon","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"R27-6-20210204","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/bjo.86.2.181","article-title":"Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye.","volume":"86","author":"Aragona","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"R28-6-20210204","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/978-1-4615-2417-5_78","article-title":"Evaluation of a physiological tear substitute in patients with keratoconjunctivitis sicca.","volume":"350","author":"Nelson","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"R29-6-20210204","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0161-6420(02)01219-8","article-title":"Trehalose eye drops in the treatment of dry eye syndrome.","volume":"109","author":"Matsuo","year":"2002","journal-title":"Ophthalmology"},{"key":"R30-6-20210204","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0161-6420(97)30124-9","article-title":"Efficacy and safety of 0.3% carbomer gel compared to placebo in patients with moderate-to-severe dry eye syndrome.","volume":"104","author":"Sullivan","year":"1997","journal-title":"Ophthalmology"},{"key":"R31-6-20210204","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0161-6420(99)00176-1","article-title":"Two multicentre, randomised studies of the efficacy and safety of cyclosporine ophthalmic emulsion moderate to severe dry eye disease.","volume":"107","author":"Sall","year":"2000","journal-title":"Ophthalmology"},{"key":"R32-6-20210204","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1185\/030079905X26252","article-title":"An open-label evaluation of HP-guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population.","volume":"21","author":"Hartstein","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"R33-6-20210204","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/01.ico.0000133993.14768.a9","article-title":"Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye.","volume":"23","author":"Tauber","year":"2004","journal-title":"Cornea"},{"key":"R34-6-20210204","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/bjo.87.10.1279","article-title":"Albumin as a tear supplement in the treatment of severe dry eye.","volume":"87","author":"Shimmura","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"R35-6-20210204","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archopht.1988.01060130530029","article-title":"Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca.","volume":"106","author":"Nelson","year":"1988","journal-title":"Arch Ophthalmol"}],"container-title":["Cornea"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ICO.0b013e3181d82f5e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T19:31:54Z","timestamp":1621884714000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003226-201011000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/ico.0b013e3181d82f5e","relation":{},"ISSN":["0277-3740"],"issn-type":[{"value":"0277-3740","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}