{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:15:00Z","timestamp":1790540100575,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1097\/ico.0b013e3182541e9a","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T10:50:06Z","timestamp":1338979806000},"page":"211-216","source":"Crossref","is-referenced-by-count":76,"title":["The Practical Detection of MMP-9 Diagnoses Ocular Surface Disease and May Help Prevent Its Complications"],"prefix":"10.1097","volume":"32","author":[{"given":"Herbert E.","family":"Kaufman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210204","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1001\/archopht.1969.00990020110026","article-title":". Coagenase in corneal ulcerations.","volume":"82","author":"Slansky","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"R2-19-20210204","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-4835(71)80030-1","article-title":". Characterization of collagenolytic activity in the ulcerating cornea.","volume":"11","author":"Berman","year":"1971","journal-title":"Exp Eye Res"},{"key":"R3-19-20210204","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1001\/archopht.1971.01000010310014","article-title":". Collagenase activity of intact corneal epithelium in peripheral alkali burns.","volume":"86","author":"Pfister","year":"1971","journal-title":"Arch Ophthalmol"},{"key":"R4-19-20210204","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0006-291X(82)90612-X","article-title":". Increased collagenase and gelatinase activities in keratoconus.","volume":"107","author":"Kao","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"R5-19-20210204","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10384-003-0022-2","article-title":". Gelatinase expression in ocular surface disorders.","volume":"48","author":"Sakimoto","year":"2004","journal-title":"Jpn J Ophthalmol"},{"issue":"suppl 1","key":"R6-19-20210204","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/bjo.2009.168849","article-title":". Emerging treatment paradigms of ocular surface disease: proceedings of the Ocular Surface Workshop.","volume":"94","author":"Rolando","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"R7-19-20210204","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3109\/02713683.2010.490320","article-title":". Topical cyclosporine in thyroid orbitopathy-related dry eye: clinical findings, conjunctival epithelial apoptosis, and MMP-9 expression.","volume":"35","author":"Gurdal","year":"2010","journal-title":"Curr Eye Res"},{"key":"R8-19-20210204","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00003226-200007000-00015","article-title":"Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practice.","volume":"19","author":"Nichols","year":"2000","journal-title":"Cornea"},{"key":"R9-19-20210204","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00003226-200404000-00010","article-title":"The repeatability of clinical measurements of dry eye.","volume":"23","author":"Nichols","year":"2004","journal-title":"Cornea"},{"key":"R10-19-20210204","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00003226-200009000-00009","article-title":"The diagnosis and management of dry eye: a twenty-five-year review.","volume":"19","author":"Pflugfelder","year":"2000","journal-title":"Cornea"},{"key":"R11-19-20210204","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00003226-200007000-00016","article-title":"Survey of preferred tests for diagnosis of the tear film and dry eye.","volume":"19","author":"Korb","year":"2000","journal-title":"Cornea"},{"key":"R15-19-20210204","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1167\/iovs.08-2476","article-title":"Li de Q, et al.. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome.","volume":"50","author":"Chotikavanich","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R16-19-20210204","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/ICU.0b013e32834787bb","article-title":"MMP-9 and the perioperative management of LASIK surgery.","volume":"22","author":"Sambursky","year":"2011","journal-title":"Curr Opin Ophthalmol"},{"key":"R17-19-20210204","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0945-053X(98)90116-0","article-title":". A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids: saliva from patients with Sjogrens syndrome contain increased latent and active gelatinase-B levels.","volume":"17","author":"Hanemaaijer","year":"1998","journal-title":"Matrix Biol"},{"key":"R18-19-20210204","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0945-053X(98)90086-5","article-title":". Matrix metalloproteinase (MMP)-9 type IV collagenasegelatinase implicated in the pathogenesis of Sjogrens syndrome.","volume":"17","author":"Konttinen","year":"1998","journal-title":"Matrix Biol"},{"key":"R19-19-20210204","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","article-title":". Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogrens syndrome keratoconjunctivitis sicca.","volume":"19","author":"Pflugfelder","year":"1999","journal-title":"Curr Eye Res"},{"key":"R20-19-20210204","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0161-6420(98)91236-2","article-title":". Elevated tear interleukin-6 levels in patients with Sjogren syndrome.","volume":"105","author":"Tishler","year":"1998","journal-title":"Ophthalmology"},{"key":"R21-19-20210204","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/rheumatology\/keh369","article-title":". Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogrens syndrome.","volume":"43","author":"Hulkkonen","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"R22-19-20210204","first-page":"2283","article-title":". Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease.","volume":"42","author":"Solomon","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R23-19-20210204","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9440(10)62232-8","article-title":". Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye.","volume":"166","author":"Pflugfelder","year":"2005","journal-title":"Am J Pathol"},{"key":"R24-19-20210204","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1167\/iovs.02-1319","article-title":". Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca.","volume":"44","author":"Song","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R25-19-20210204","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1167\/iovs.05-1382","article-title":". Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.","volume":"47","author":"Corrales","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R26-19-20210204","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1167\/iovs.04-0299","article-title":". Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.","volume":"45","author":"Li","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R27-19-20210204","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bjo.85.2.147","article-title":". Tear film MMP accumulation and corneal disease.","volume":"85","author":"Smith","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"R28-19-20210204","first-page":"3221","article-title":"Mechanism of basement membrane dissolution preceding corneal ulceration.","volume":"32","author":"Matsubara","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R29-19-20210204","first-page":"1287","article-title":". Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury.","volume":"149","author":"Fini","year":"1996","journal-title":"Am J Pathol"},{"key":"R30-19-20210204","first-page":"4142","article-title":"Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head.","volume":"41","author":"Di Girolamo","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R31-19-20210204","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.exer.2004.05.003","article-title":". TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells.","volume":"79","author":"Kim","year":"2004","journal-title":"Exp Eye Res"},{"key":"R32-19-20210204","first-page":"90","article-title":". Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A.","volume":"42","author":"Brignole","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R33-19-20210204","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00003226-200007000-00018","article-title":". Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion.","volume":"19","author":"Turner","year":"2000","journal-title":"Cornea"},{"key":"R34-19-20210204","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/ICO.0b013e318158f6dc","article-title":". Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production.","volume":"27","author":"Pflugfelder","year":"2008","journal-title":"Cornea"},{"key":"R35-19-20210204","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9394(03)00326-X","article-title":". The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study.","volume":"136","author":"Avunduk","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R36-19-20210204","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1177\/112067210901900504","article-title":". In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis.","volume":"19","author":"Iovieno","year":"2009","journal-title":"Eur J Ophthalmol"},{"key":"R37-19-20210204","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.exer.2006.02.004","article-title":". Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.","volume":"83","author":"De Paiva","year":"2006","journal-title":"Exp Eye Res"},{"key":"R38-19-20210204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/112067210701700101","article-title":"Dry eye after LASIK for myopia: incidence and risk factors.","volume":"17","author":"Shoja","year":"2007","journal-title":"Eur J Ophthalmol"},{"key":"R39-19-20210204","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1001\/archophthalmol.2010.23","article-title":". Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis.","volume":"128","author":"Fournie","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"R40-19-20210204","first-page":"1266","article-title":". Matrix metalloproteinases in epithelia from human recurrent corneal erosion.","volume":"40","author":"Garrana","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R41-19-20210204","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9394(01)00913-8","article-title":". Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids.","volume":"132","author":"Dursun","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"R43-19-20210204","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1442-9071.2007.01648.x","article-title":"Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid.","volume":"36","author":"Wang","year":"2008","journal-title":"Clin Experiment Ophthalmol"},{"key":"R44-19-20210204","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1398-9995.2008.01858.x","article-title":". Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.","volume":"64","author":"Leonardi","year":"2009","journal-title":"Allergy"},{"key":"R45-19-20210204","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1067\/mai.2002.126379","article-title":". Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis.","volume":"110","author":"Kumagai","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"R46-19-20210204","first-page":"4175","article-title":". Growth factors and collagen distribution in vernal keratoconjunctivitis.","volume":"41","author":"Leonardi","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R47-19-20210204","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.02-0766","article-title":". Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis.","volume":"44","author":"Leonardi","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R48-19-20210204","first-page":"207","article-title":". Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis.","volume":"26","author":"Rohini","year":"2007","journal-title":"Cornea"},{"key":"R49-19-20210204","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/bjo.2008.144253","article-title":". Subclinical keratoconus and inflammatory molecules from tears.","volume":"93","author":"Lema","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"R50-19-20210204","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1167\/iovs.03-1145","article-title":". Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface.","volume":"45","author":"Luo","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R51-19-20210204","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1749-6632.1999.tb07679.x","article-title":". The scientific basis and development of a matrix metalloproteinase (MMP) -8 specific chair-side test for monitoring of periodontal health and disease from gingival crevicular fluid.","volume":"878","author":"Sorsa","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"R52-19-20210204","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000150445","article-title":". Inflammatory markers in the tears of patients with ocular surface disease.","volume":"40","author":"Acera","year":"2008","journal-title":"Ophthalmic Res"},{"key":"R53-19-20210204","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1006\/exer.2001.1054","article-title":". Regulation of MMP-9 production by human corneal epithelial cells.","volume":"73","author":"Li","year":"2001","journal-title":"Exp Eye Res"},{"key":"R56-19-20210204","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/ICO.0b013e31803dcda2","article-title":". Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome.","volume":"26","author":"Yoon","year":"2007","journal-title":"Cornea"},{"key":"R57-19-20210204","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1167\/iovs.05-1364","article-title":"Conjunctival cytokine expression in symptomatic moderate dry eye subjects.","volume":"47","author":"Narayanan","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Cornea"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ICO.0b013e3182541e9a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T19:34:01Z","timestamp":1621884841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003226-201302000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/ico.0b013e3182541e9a","relation":{},"ISSN":["0277-3740"],"issn-type":[{"value":"0277-3740","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}