{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:07:43Z","timestamp":1786118863234,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1097\/icu.0b013e3282fb7c04","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T03:16:46Z","timestamp":1207883806000},"page":"213-217","source":"Crossref","is-referenced-by-count":53,"title":["Ocular von Hippel\u2013Lindau disease: clinical update and emerging treatments"],"prefix":"10.1097","volume":"19","author":[{"given":"Wai T","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210206","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel\u2013Lindau disease","volume":"361","author":"Lonser","year":"2003","journal-title":"Lancet"},{"key":"R2-9-20210206","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0039-6257(01)00245-4","article-title":"von Hippel-Lindau disease","volume":"46","author":"Singh","year":"2001","journal-title":"Surv Ophthalmol"},{"key":"R3-9-20210206","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9343(64)90107-X","article-title":"Lindau's Disease: Review of the literature and study of a large kindred","volume":"36","author":"Melmon","year":"1964","journal-title":"Am J Med"},{"key":"R4-9-20210206","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.ophtha.2006.02.059","article-title":"Retinal angiomatosis in von Hippel-Lindau disease: a longitudinal ophthalmologic study","volume":"113","author":"Kreusel","year":"2006","journal-title":"Ophthalmology"},{"key":"R5-9-20210206","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"R6-9-20210206","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K","article-title":"Improved detection of germline mutations in the von Hippel\u2013Lindau disease tumor suppressor gene","volume":"12","author":"Stolle","year":"1998","journal-title":"Hum Mutat"},{"key":"R7-9-20210206","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1086\/302726","article-title":"Mosaicism in von Hippel\u2013Lindau disease: lessons from kindreds with germline mutations identified in offspring with mosaic parents","volume":"66","author":"Sgambati","year":"2000","journal-title":"Am J Hum Genet"},{"key":"R8-9-20210206","first-page":"582","article-title":"von Hippel\u2013Lindau disease: genetic, clinical, and imaging features","volume":"196","author":"Choyke","year":"1995","journal-title":"Radiology"},{"key":"R9-9-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"R10-9-20210206","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.cellbio.15.1.551","article-title":"Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1","volume":"15","author":"Semenza","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R11-9-20210206","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrc885","article-title":"Molecular basis of the VHL hereditary cancer syndrome","volume":"2","author":"Kaelin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"R12-9-20210206","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3","article-title":"Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan","volume":"8","author":"Zbar","year":"1996","journal-title":"Hum Mutat"},{"key":"R13-9-20210206","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/nar\/26.1.256","article-title":"Software and database for the analysis of mutations in the VHL gene","volume":"26","author":"Beroud","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"R14-9-20210206","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.molmed.2004.02.004","article-title":"von Hippel\u2013Lindau tumor suppressor: not only HIF's executioner","volume":"10","author":"Czyzyk-Krzeska","year":"2004","journal-title":"Trends Mol Med"},{"key":"R15-9-20210206","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/08820530500350787","article-title":"Antiangiogenic therapy: Prospects for treatment of ocular tumors","volume":"21","author":"Rosenblatt","year":"2006","journal-title":"Semin Ophthalmol"},{"key":"R16-9-20210206","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archopht.125.9.1189","article-title":"Internal en bloc resection and genetic analysis of retinal capillary hemangioblastoma","volume":"125","author":"Schlesinger","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"R17-9-20210206","first-page":"48","article-title":"Therapeutic options for capillary papillary hemangiomas","volume":"107","author":"Garcia-Arumi","year":"2000","journal-title":"Ophthalmology"},{"key":"R18-9-20210206","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0161-6420(02)01059-X","article-title":"Benefits and complications of photodynamic therapy of papillary capillary hemangiomas","volume":"109","author":"Schmidt-Erfurth","year":"2002","journal-title":"Ophthalmology"},{"key":"R20-9-20210206","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archopht.117.3.371","article-title":"Clinical characteristics of ocular angiomatosis in von Hippel-Lindau disease and correlation with germline mutation","volume":"117","author":"Webster","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"R21-9-20210206","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/humu.20385","article-title":"Genotype-phenotype correlations in von Hippel-Lindau disease","volume":"28","author":"Ong","year":"2007","journal-title":"Hum Mutat"},{"key":"R22-9-20210206","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/humu.1380050109","article-title":"Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype","volume":"5","author":"Chen","year":"1995","journal-title":"Hum Mutat"},{"key":"R23-9-20210206","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3","article-title":"Germline mutations in the Von Hippel\u2013Lindau disease (VHL) gene in families from North America, Europe, and Japan","volume":"8","author":"Zbar","year":"1996","journal-title":"Hum Mutat"},{"key":"R24-9-20210206","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1365-2796.1998.00336.x","article-title":"Genotype-phenotype correlations in von Hippel\u2013Lindau disease","volume":"243","author":"Neumann","year":"1998","journal-title":"J Intern Med"},{"key":"R25-9-20210206","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1001\/jama.297.7.733","article-title":"Genetic ophthalmology and the era of clinical care","volume":"297","author":"Sieving","year":"2007","journal-title":"JAMA"},{"key":"R26-9-20210206","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archopht.125.2.196","article-title":"Molecular diagnosis and genetic counseling in ophthalmology","volume":"125","author":"Blain","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"R27-9-20210206","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1001\/archopht.125.2.239","article-title":"Genotype-phenotype correlation in von Hippel\u2013Lindau disease with retinal angiomatosis","volume":"125","author":"Wong","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"R28-9-20210206","first-page":"3067","article-title":"Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study","volume":"43","author":"Dollfus","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R29-9-20210206","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.284.5413.455","article-title":"Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function","volume":"284","author":"Stebbins","year":"1999","journal-title":"Science"},{"key":"R30-9-20210206","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1056\/NEJMoa021491","article-title":"A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer","volume":"349","author":"Yang","year":"2003","journal-title":"N Engl J Med"},{"key":"R31-9-20210206","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1200\/JCO.2007.11.5154","article-title":"Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer","volume":"25","author":"Bukowski","year":"2007","journal-title":"J Clin Oncol"},{"key":"R32-9-20210206","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa065044","article-title":"Sunitinib versus interferon alfa in metastatic renal-cell carcinoma","volume":"356","author":"Motzer","year":"2007","journal-title":"N Engl J Med"},{"key":"R33-9-20210206","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0161-6420(02)01159-4","article-title":"Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416","volume":"109","author":"Aiello","year":"2002","journal-title":"Ophthalmology"},{"key":"R34-9-20210206","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9394(03)00101-6","article-title":"Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas","volume":"136","author":"Girmens","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R35-9-20210206","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/jama.291.8.943","article-title":"Antiangiogenic therapy for von Hippel-Lindau disease","volume":"291","author":"Madhusudan","year":"2004","journal-title":"JAMA"},{"key":"R36-9-20210206","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0420.2006.00825.x","article-title":"Systemic bevacizumab treatment of a juxtapapillary retinal haemangioma","volume":"85","author":"von Buelow","year":"2007","journal-title":"Acta Ophthalmol Scand"},{"key":"R37-9-20210206","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/sj.eye.6702896","article-title":"Combined treatment of a juxtapapillary retinal capillary haemangioma with intravitreal bevacizumab and photodynamic therapy","volume":"21","author":"Ziemssen","year":"2007","journal-title":"Eye"},{"key":"R38-9-20210206","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/IAE.0b013e318030a290","article-title":"Intravitreal antivascular endothelial growth factor therapy with pegaptanib for advanced von Hippel-Lindau disease of the retina","volume":"27","author":"Dahr","year":"2007","journal-title":"Retina"}],"container-title":["Current Opinion in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ICU.0b013e3282fb7c04","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:57:28Z","timestamp":1786035448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00055735-200805000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/icu.0b013e3282fb7c04","relation":{},"ISSN":["1040-8738"],"issn-type":[{"value":"1040-8738","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}