{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:19:24Z","timestamp":1759331964289,"version":"3.41.2"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1097\/igc.0b013e3182009eea","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T04:00:38Z","timestamp":1292299238000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Evaluation of p16ink4a Immunoexpression\/Immunostaining and Human Papillomavirus DNA Test in Cervical Liquid-Based Cytological Samples"],"prefix":"10.1016","volume":"21","author":[{"given":"Maria","family":"Nasioutziki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Daniilidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostos","family":"Dinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kyrgiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Valasoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis D.","family":"Loufopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaggelos","family":"Paraskevaidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristotelis","family":"Loufopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Karakitsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1097\/IGC.0b013e3182009eea_bb0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1386-6532(00)00125-6","article-title":"Human papillomavirus and cancer: the epidemiological evidence","volume":"19","author":"Munoz","year":"2000","journal-title":"J Clin Virol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ygyno.2006.08.053","article-title":"Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies","volume":"104","author":"Koliopoulos","year":"2007","journal-title":"Gynecol Oncol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/jnci\/djh037","article-title":"Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia","volume":"96","author":"Arbyn","year":"2004","journal-title":"J Natl Cancer Inst."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ctrv.2003.07.008","article-title":"The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature","volume":"30","author":"Paraskevaidis","year":"2004","journal-title":"Cancer Treat Rev."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0030","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.ygyno.2005.07.033","article-title":"Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence","volume":"99","author":"Arbyn","year":"2005","journal-title":"Gynecol Oncol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0035","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.vaccine.2006.05.117","article-title":"Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses","volume":"24","author":"Arbyn","year":"2006","journal-title":"Vaccine."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0040","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ctrv.2007.05.002","article-title":"Management of minor cervical cytological abnormalities: a systematic review and a meta-analysis of the literature","volume":"33","author":"Kyrgiou","year":"2007","journal-title":"Cancer Treat Rev."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1155\/2007\/678793","article-title":"Biomarkers in cervical cancer screening","volume":"23","author":"Wentzensen","year":"2007","journal-title":"Dis Markers."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ctrv.2008.10.005","article-title":"P16 INK4a in cervical cytology and histology: systemic review and metanalysis","volume":"35","author":"Tsoumpou","year":"2009","journal-title":"Cancer Treat Rev."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0055","first-page":"7075","article-title":"The human Papillomavirus Type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability","volume":"62","author":"Duensing","year":"2002","journal-title":"Cancer Res."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jcp.56.1.56","article-title":"P16INK4a as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep\u2122 smears","volume":"56","author":"Murphy","year":"2003","journal-title":"J Clin Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/cncr.22420","article-title":"Triage of women Ascus and LSIL cytology. Use of qualitative assessment of p16 INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia","volume":"111","author":"Wentzensen","year":"2007","journal-title":"Cancer Cytopathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s004280100439","article-title":"Expression of cyclin dependent kinase inhibitors p16MTS1, p21WAF1 and p27KIP1 in HPV positive and HPV negative cervical adenocarcinomas","volume":"439","author":"Milde-Langosch","year":"2001","journal-title":"Virchows Arch."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0075","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cncr.21378","article-title":"Evaluation of a nuclear score for p16INK4a stained cervical squamous cells in liquid-based cytology samples","volume":"105","author":"Wentzensen","year":"2005","journal-title":"Cancer."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0080","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1159\/000326445","article-title":"Morphologic characteristics of p16INK4a positive cells in cervical cytology samples","volume":"25","author":"Trunk","year":"2004","journal-title":"Acta Cytol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0085","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.ajog.2004.06.107","article-title":"Colposcopy quality control by remote review of digitized colposcopy images","volume":"191","author":"Ferris","year":"2004","journal-title":"Am J Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0090","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(06)68181-6","article-title":"Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis","volume":"367","author":"Kyrgiou","year":"2006","journal-title":"Lancet."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.a1284","article-title":"Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis","volume":"337","author":"Arbyn","year":"2008","journal-title":"BMJ."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1471-0528.2006.01178.x","article-title":"Have we dismissed ablative treatment too soon in colposcopy practice?","volume":"114","author":"Paraskevaidis","year":"2007","journal-title":"BJOG."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0105","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/01.MP.0000077518.78046.0C","article-title":"P16INK4a expression correlates with degree of cervical neoplasia: a comparison with ki-67 expression and detection of high risk HPV types","volume":"16","author":"Agoff","year":"2003","journal-title":"Mod Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0110","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1159\/000326578","article-title":"Immunochemical detection of p16INK4a protein in scraped cervical cells","volume":"47","author":"Pietong","year":"2003","journal-title":"Acta Cytol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0115","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00000478-200107000-00006","article-title":"Ki-67, cycil E and p16INK4a are complementary surrogate biomarkers for human papilloma virus related cervical neoplasia","volume":"25","author":"Keatin","year":"2001","journal-title":"Am J Surg Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0120","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S1470-2045(08)70208-0","article-title":"Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial","volume":"9","author":"Carozzi","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1097\/IGC.0b013e3182009eea_bb0125","first-page":"894","article-title":"The predictive value of p16INK4a and hybrid capture 2 Human Papillomavirus testing for high-grade cervical intraepithelial neoplasia","volume":"122","author":"Guo","year":"2004","journal-title":"Anat Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.pas.0000213347.65014.ee","article-title":"P16INK4a immunohistochemistry is superior to HPV in situ hybridization for the detection of high risk HPV in atypical squamous metaplasia","volume":"31","author":"Kong","year":"2007","journal-title":"Am J Surg Pathol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/01.lgt.0000245042.29847.dd","article-title":"Immunohistochemical expression of p16INK4a in normal uterine cervix, nonneoplastic epithelial lesions and low-grade squamous intraepithelial lesions","volume":"11","author":"Focchi","year":"2007","journal-title":"J Low Genit Tract Dis."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0140","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"Klaes","year":"2001","journal-title":"Int J Cancer."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ygyno.2004.11.034","article-title":"Is p16INK4a expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorised Pap smear? A comparative analysis using abnormal cervical smears follow-up biopsies","volume":"97","author":"Nieh","year":"2005","journal-title":"Gynecol Oncol."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.22580","article-title":"Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay","volume":"111","author":"Meyer","year":"2007","journal-title":"Cancer."},{"key":"10.1097\/IGC.0b013e3182009eea_bb0155","first-page":"8","article-title":"P16INK4A as an adjunct test in liquid-based cytology","volume":"25","author":"Bibbo","year":"2003","journal-title":"Anal Quant Cytol Histol."}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24200062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24200062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1097\/IGC.0b013e3182009eea","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T18:41:52Z","timestamp":1753209712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24200062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1048891X24200062"],"URL":"https:\/\/doi.org\/10.1097\/igc.0b013e3182009eea","relation":{},"ISSN":["1048-891X"],"issn-type":[{"type":"print","value":"1048-891X"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Evaluation of p16ink4a Immunoexpression\/Immunostaining and Human Papillomavirus DNA Test in Cervical Liquid-Based Cytological Samples","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/IGC.0b013e3182009eea","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright Copyright \u00a9 2011 by IGCS and ESGO.","name":"copyright","label":"Copyright"}]}}