{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:18:42Z","timestamp":1785777522187,"version":"3.56.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1097\/igc.0b013e31825104bd","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T11:21:31Z","timestamp":1337858491000},"page":"742-747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Role of Chromosome 3q26 Gain in Predicting Progression of Cervical Dysplasia"],"prefix":"10.1016","volume":"22","author":[{"given":"Alexandros","family":"Rodolakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Biliatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hera","family":"Symiakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kershnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Haidopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Thomakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Antsaklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/IGC.0b013e31825104bd_bb0005","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.5858\/2004-128-1224-BIARRP","article-title":"Bethesda 2001 implementation and reporting rates: 2003 practices of participants in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology","volume":"128","author":"Davey","year":"2004","journal-title":"Arch Pathol Lab Med."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0010","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0002-9378(03)00413-7","article-title":"A randomized trial on the management of low grade squamous intraepithelial lesion cytology interpretations","volume":"188","author":"ALTS Group","year":"2003","journal-title":"Am J Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0015","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/S0140-6736(04)17354-6","article-title":"Regression of low-grade squamous intra-epithelial lesions in young women","volume":"364","author":"Moscicki","year":"2004","journal-title":"Lancet."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0025","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","article-title":"2006 Consensus guidelines for the management of women with abnormal cervical cancer screening tests","volume":"197","author":"Wright","year":"2007","journal-title":"Am J Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jnci\/djj009","article-title":"Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study (ALTS)","volume":"98","author":"Kulasingam","year":"2006","journal-title":"J Natl Cancer Inst."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00001703-199602000-00015","article-title":"The pathology of cervical neoplasia","volume":"8","author":"Ostor","year":"1996","journal-title":"Curr Opin Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0040","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1073\/pnas.93.1.479","article-title":"Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix","volume":"93","author":"Heselmeyer","year":"1996","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<233::AID-GCC5>3.0.CO;2-Y","article-title":"Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q","volume":"19","author":"Heselmeyer","year":"1997","journal-title":"Genes Chromosomes Cancer."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0050","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)63498-0","article-title":"Detection of genomic amplif ication of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia","volume":"163","author":"Heselmeyer-Haddad","year":"2003","journal-title":"Am J Pathol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0055","first-page":"37","article-title":"Gain of the 3q26 region in cervicovaginal liquidbased Pap preparations is associated","volume":"110","author":"Caraway","year":"2008","journal-title":"with squamous intraepithelial lesions and squamous cell carcinoma. Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31825104bd_bb0060","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ygyno.2009.03.031","article-title":"Gain of 3q26: a genetic marker in low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix","volume":"114","author":"Seppo","year":"2009","journal-title":"Gynecol Oncol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0065","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/path.2070","article-title":"Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer","volume":"210","author":"Hopman","year":"2006","journal-title":"J Pathol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0070","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/IGC.0b013e3181b62ea5","article-title":"Gain of the human telomerase RNA gene TERC at 3q26 is strongly associated with cervical intraepithelial neoplasia and carcinoma","volume":"19","author":"Sui","year":"2009","journal-title":"IntJ Gynecol Cancer."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0075","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2009.090122","article-title":"Detection of genomic amplif ication of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears","volume":"175","author":"Andersson","year":"2009","journal-title":"Am J Pathol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0080","doi-asserted-by":"crossref","first-page":"581.e1","DOI":"10.1016\/j.ajog.2009.12.016","article-title":"Amplification of the chromosome 3q26 region shows high negative predictive value for non-malignant transformation of LSIL cytology","volume":"202","author":"Jalali","year":"2010","journal-title":"Am J Obstet Gynecol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0085","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1128\/JVI.78.21.11451-11460.2004","article-title":"Mechanisms of human papilloma virus induced oncogenesis","volume":"78","author":"Munger","year":"2004","journal-title":"J Virol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0090","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1093\/carcin\/23.12.2025","article-title":"The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation","volume":"12","author":"Guilleret","year":"2002","journal-title":"Carcinogenesis."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0095","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1038\/sj.onc.1203597","article-title":"Pik3ca as an oncogene in cervical Cancer","volume":"19","author":"Ma","year":"2000","journal-title":"Oncogene."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0100","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0002-9440(10)62341-3","article-title":"Genomic amplification of the human telomerase gene (TERC) in Pap smears predicts the development of cervical cancer","volume":"166","author":"Heselmeyer-Haddad","year":"2005","journal-title":"Am J Pathol."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jnci\/92.5.397","article-title":"The ALTS Group: human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial","volume":"92","author":"Koutsky","year":"2000","journal-title":"J Natl Cancer Inst."},{"key":"10.1097\/IGC.0b013e31825104bd_bb0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"Comparison of three management strategies for patients with atypical squamous cells of undetermined signif icance: baseline results from a randomized trial","volume":"93","author":"Solomon","year":"2001","journal-title":"J Natl Cancer Inst."}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24088078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24088078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:09:08Z","timestamp":1753232948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24088078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1048891X24088078"],"URL":"https:\/\/doi.org\/10.1097\/igc.0b013e31825104bd","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Chromosome 3q26 Gain in Predicting Progression of Cervical Dysplasia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/IGC.0b013e31825104bd","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright Copyright \u00a9 2012 by IGCS and ESGO.","name":"copyright","label":"Copyright"}]}}