{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:14:17Z","timestamp":1789848857933,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1097\/igc.0b013e31829703ea","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T08:01:14Z","timestamp":1369468874000},"page":"1150-1156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Linear Regression of Postevacuation Serum Human Chorionic Gonadotropin Concentrations Predicts Postmolar Gestational Trophoblastic Neoplasia"],"prefix":"10.1016","volume":"23","author":[{"given":"Charlotte","family":"Lybol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred C.G.J.","family":"Sweep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella B.","family":"Ottevanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon F.A.G.","family":"Massuger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/IGC.0b013e31829703ea_bb0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ygyno.2011.01.002","article-title":"Increase in the incidence of gestational trophoblastic disease in The Netherlands","volume":"121","author":"Lybol","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0020-7292(00)90001-8","article-title":"FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology","volume":"70","author":"Benedet","year":"2000","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0020","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/gyno.2000.5823","article-title":"Measurement of CA-125 in trophoblastic disease","volume":"78","author":"Kohorn","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0030","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ygyno.2006.04.015","article-title":"Evaluation of deletions in 7q11.2 and 8p12-p21 as prognostic indicators of tumour development following molar pregnancy","volume":"103","author":"Burke","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0002-9378(86)90818-5","article-title":"Radioimmunoassay of free beta-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy","volume":"155","author":"Khazaeli","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0040","first-page":"591","article-title":"Predictors of persistent disease in women with complete hydatidiform mole","volume":"41","author":"Ayhan","year":"1996","journal-title":"J Reprod Med"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/gyno.1998.5210","article-title":"Identification of persistent trophoblastic diseases based on a human chorionic gonadotropin regression curve by means of a stepwise piecewise linear regression analysis after the evacuation of uneventful moles","volume":"71","author":"Shigematsu","year":"1998","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0050","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/01.AOG.0000174583.51617.25","article-title":"Postevacuation hCG levels and risk of gestational trophoblastic neoplasia in women with complete molar pregnancy","volume":"106","author":"Wolfberg","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0055","first-page":"478","article-title":"Prognostic characteristics of serum human chorionic gonadotropin titer regression following molar pregnancy","volume":"58","author":"Schlaerth","year":"1981","journal-title":"Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0060","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1530\/eje.1.01997","article-title":"Diagnosis of hydatidiform mole and persistent trophoblastic disease: diagnostic accuracy of total human chorionic gonadotropin (hCG), free hCG {alpha}-and {beta}-subunits, and their ratios","volume":"153","author":"van Trommel","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0065","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1525-1438.2007.00993.x","article-title":"Early identif ication of persistent trophoblastic disease with serum hCG concentration ratios","volume":"18","author":"van Trommel","year":"2008","journal-title":"Int J Gynecol Cancer"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ygyno.2010.01.008","article-title":"Pre-evacuation hCG glycoforms in uneventful complete hydatidiform mole and persistent trophoblastic disease","volume":"117","author":"Thomas","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0075","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/000456328502200305","article-title":"Comparison of the analytical characteristics and clinical usefulness in tumour monitoring of fifteen hCG(-beta) immunoassay kits","volume":"22","author":"Thomas","year":"1985","journal-title":"Ann Clin Biochem"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0080","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1126\/science.3287615","article-title":"Measuring the accuracy of diagnostic systems","volume":"240","author":"Swets","year":"1988","journal-title":"Science"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1210\/jcem-64-2-313","article-title":"Radioimmunoassay of the serum free beta-subunit of human chorionic gonadotropin in trophoblastic disease","volume":"64","author":"Fan","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9378(88)90809-5","article-title":"Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease","volume":"158","author":"Ozturk","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0095","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0010-7824(98)00028-6","article-title":"Identification of choriocarcinoma by the hCG beta-to-hCG proportion in patients with delayed diagnosis caused by contraceptive use","volume":"57","author":"Vartiainen","year":"1998","journal-title":"Contraception"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0100","first-page":"643","article-title":"Human chorionic gonadotropin free beta-subunit measurement as a marker of placental site trophoblastic tumours","volume":"53","author":"Harvey","year":"2008","journal-title":"J Reprod Med"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0002-9378(12)90820-0","article-title":"Identification of patients with persistent trophoblastic disease by means of a normal human chorionic gonadotropin regression curve","volume":"168","author":"Yedema","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0110","first-page":"980","article-title":"Is normal beta-hCG regression curve helpful in the diagnosis of persistent trophoblastic disease?","volume":"14","author":"Behtash","year":"2004","journal-title":"Int J Gynecol Cancer"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0090-8258(88)90150-3","article-title":"Comparison of human chorionic gonadotropin regression in molar pregnancies and post-molar nonmetastatic gestational trophoblastic neoplasia","volume":"29","author":"Rotmensch","year":"1988","journal-title":"Gynecol Oncol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0120","first-page":"78","article-title":"Hydatidiform mole and gestational trophoblastic disease in Southern Connecticut","volume":"59","author":"Kohorn","year":"1982","journal-title":"Obstet Gynecol"},{"key":"10.1097\/IGC.0b013e31829703ea_bb0125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0002-9378(77)90562-2","article-title":"Clinical and laboratory correlates of molar pregnancy and trophoblastic disease","volume":"128","author":"Morrow","year":"1977","journal-title":"Am J Obstet Gynecol"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24087619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24087619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:56:43Z","timestamp":1753228603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24087619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1048891X24087619"],"URL":"https:\/\/doi.org\/10.1097\/igc.0b013e31829703ea","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linear Regression of Postevacuation Serum Human Chorionic Gonadotropin Concentrations Predicts Postmolar Gestational Trophoblastic Neoplasia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/IGC.0b013e31829703ea","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright Copyright \u00a9 2013 by IGCS and ESGO.","name":"copyright","label":"Copyright"}]}}