{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:27:56Z","timestamp":1791570476681,"version":"4.3.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To investigate the usefulness of removing the large vessel\u2013related information from peripapillary optical coherence tomography angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel\u2013related effects were reevaluated for selective peripapillary capillary VD progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>Prospective retinal nerve fiber layer thickness and peripapillary VD measurements were made using the Angiovue\/RTvue-XR OCT on 1 eye of 9 normal, 20 under treatment ocular hypertensive, and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits). In the current investigation the previously analyzed images were reanalyzed. Linear regression analysis for capillary VD progression in the radial peripapillary capillaries layer of the superior and inferior peripapillary hemifields, respectively, was made using the instrument\u2019s new software (version 2017.1, Phase 7 update).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A statistically significant negative capillary VD slope was found in 4 glaucoma eyes. Two eyes progressed in both hemifields, and 2 eyes in 1 hemifield. The rate of statistically significant progression ranged between \u22121.3% and\u22123.2% per year. In 2 eyes the spatially corresponding hemifield retinal nerve fiber layer thickness progression was also significant (\u22121.4\u2009\u03bcm\/y and \u22121.8\u2009\u03bcm\/y). No normal and ocular hypertensive eyes showed significant capillary VD progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In this 2-year prospective study no eye showed progression for peripapillary VD when all vessel-related information was used. In contrast, software-provided removal of the large retinal vessels\u2013related information resulted in detection of significant capillary VD progression in 17% of the glaucoma eyes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ijg.0000000000000990","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T23:46:13Z","timestamp":1526427973000},"page":"e137-e139","source":"Crossref","is-referenced-by-count":30,"title":["Influence of Removing the Large Retinal Vessels\u2013related Effect on Peripapillary Vessel Density Progression Analysis in Glaucoma"],"prefix":"10.1097","volume":"27","author":[{"given":"G\u00e1bor","family":"Holl\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230912","doi-asserted-by":"crossref","first-page":"OCT451","DOI":"10.1167\/iovs.15-18944","article-title":"Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes","volume":"57","author":"Yarmohammadi","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R2-20230912","doi-asserted-by":"crossref","first-page":"e0161631","DOI":"10.1371\/journal.pone.0161631","article-title":"Intrasession and between-visit variability of sector peripapillary angioflow vessel density values measured with the Angiovue optical coherence tomograph in different retinal layers in ocular hypertension and glaucoma","volume":"11","author":"Holl\u00f3","year":"2016","journal-title":"PLoS One"},{"key":"R3-20230912","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamaophthalmol.2015.2225","article-title":"Optical coherence tomography angiography of the peripapillary retina in glaucoma","volume":"133","author":"Liu","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"R4-20230912","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00417-015-3095-y","article-title":"Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study","volume":"253","author":"Wang","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R5-20230912","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.ophtha.2016.08.041","article-title":"Relationship between optical coherence tomography vessel density and severity of visual field loss in glaucoma","volume":"123","author":"Yarmohammadi","year":"2016","journal-title":"Ophthalmology"},{"key":"R6-20230912","doi-asserted-by":"crossref","first-page":"e0171541","DOI":"10.1371\/journal.pone.0171541","article-title":"Relationship between optical coherence tomography sector peripapillary angioflow-density and octopus visual field cluster mean defect values","volume":"12","author":"Holl\u00f3","year":"2017","journal-title":"PLoS One"},{"key":"R7-20230912","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/bjophthalmol-2016-309642","article-title":"Peripapillary perfused capillary density in primary open-angle glaucoma across disease stage: an optical coherence tomography angiography study","volume":"101","author":"Geyman","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"R8-20230912","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/IJG.0000000000000868","article-title":"Comparison of peripapillary OCT angiography vessel density and retinal nerve fiber layer thickness measurements for their ability to detect progression in glaucoma","volume":"27","author":"Holl\u00f3","year":"2018","journal-title":"J Glaucoma"}],"container-title":["Journal of Glaucoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00061198-201808000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:04:39Z","timestamp":1694552679000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00061198-201808000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/ijg.0000000000000990","relation":{},"ISSN":["1057-0829"],"issn-type":[{"value":"1057-0829","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}