{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:22:12Z","timestamp":1762899732549},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>The purpose of this study was to investigate the association between dyslipidemia treatment and open-angle glaucoma (OAG).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients and Methods:<\/jats:title>\n            <jats:p>We included 16,939 participants aged \u226540 years from the Korea National Health and Nutrition Examination Survey (2008 to 2012) and classified them into 2 groups based on current dyslipidemia treatment. The prevalence of OAG was determined using the modified International Society of Geographical and Epidemiological Ophthalmology criteria. The association between dyslipidemia treatment and OAG was evaluated using logistic mixed-effects model and propensity-score-weighted odds ratios.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Analyses using the 2 abovementioned models revealed that dyslipidemia treatment was not associated with OAG (odds ratio, 1.08; 95% confidence interval, 0.75-1.56; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.838 and 1.03; 0.71-1.48; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.882, respectively), presence of optic disc hemorrhage (0.64; 0.15-2.73; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.648 and 1.10; 0.39-3.11; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.855), high vertical cup-to-disc ratio or asymmetry (1.02; 0.81-1.28; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.736 and 0.95; 0.75-1.20; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.650), presence of retinal nerve fiber layer defects (0.97; 0.67-1.42; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.857 and 1.03; 0.75-1.42; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.857), and presence of visual field defects (0.93; 0.55-1.54; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.931 and 0.97; 0.81-1.52; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.528). Total cholesterol and high-density lipoprotein cholesterol were also not associated with OAG. However, higher serum triglyceride levels were associated with OAG in the treated patients (1.31; 1.02-1.68; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.027) but not in the untreated patients (1.03; 0.93-1.14; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.079).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In the Korean population, dyslipidemia treatment was not significantly associated with open-angle glaucoma. However, hypertriglyceridemia was associated with OAG in treated patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ijg.0000000000001237","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T03:13:14Z","timestamp":1553483594000},"page":"550-556","source":"Crossref","is-referenced-by-count":18,"title":["Dyslipidemia, Dyslipidemia Treatment, and Open-angle Glaucoma in the Korean National Health and Nutrition Examination Survey"],"prefix":"10.1097","volume":"28","author":[{"given":"Kilhwan","family":"Shon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Rim","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230912","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"R2-20230912","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41433-018-0042-2","article-title":"Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis","volume":"32","author":"Killer","year":"2018","journal-title":"Eye"},{"key":"R3-20230912","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.ophtha.2016.06.022","article-title":"Association between renal function and open-angle glaucoma: the Korea national health and nutrition examination survey 2010-2011","volume":"123","author":"Shim","year":"2016","journal-title":"Ophthalmology"},{"key":"R4-20230912","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ophtha.2015.11.004","article-title":"Prevalence, awareness, and risk factors of primary open-angle glaucoma Korea national health and nutrition examination survey 2008-2011","volume":"123","author":"Kim","year":"2016","journal-title":"Ophthalmology"},{"key":"R5-20230912","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1111\/aos.12855","article-title":"Topographic correlation between optic nerve head characteristics and retinal nerve fibre layer defect in primary open-angle glaucoma patients: Korea national health and nutrition examination survey","volume":"94","author":"Lee","year":"2016","journal-title":"Acta Ophthalmol"},{"key":"R6-20230912","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1111\/aos.13487","article-title":"Vascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea","volume":"95","author":"Lee","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"R7-20230912","first-page":"1","article-title":"Relationship between open-angle glaucoma and stroke","volume":"27","author":"Lee","year":"2017","journal-title":"J 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disease stabilization in normal tension glaucoma: a cohort study","volume":"117","author":"Leung","year":"2010","journal-title":"Ophthalmology"},{"key":"R15-20230912","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1442-9071.2007.01529.x","article-title":"Effect of statin drugs and aspirin on progression in open-angle glaucoma suspects using confocal scanning laser ophthalmoscopy","volume":"35","author":"De Castro","year":"2007","journal-title":"Clin Exp Ophthalmol"},{"key":"R16-20230912","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1167\/iovs.09-4821","article-title":"Hypotensive medication, statins, and the risk of glaucoma","volume":"51","author":"Owen","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"R17-20230912","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1185\/03007990903035083","article-title":"Effect of selected antihypertensives, antidiabetics, statins and diuretics on adjunctive medical treatment of glaucoma: 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retina","volume":"120","author":"Honjo","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"R21-20230912","first-page":"1029","article-title":"Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632","volume":"42","author":"Rao","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R22-20230912","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1167\/iovs.16-20099","article-title":"A meta-analysis of glaucoma risk in hyperlipidemic individuals: a critical problem in design","volume":"57","author":"Hwang","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"R23-20230912","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3341\/kjo.2015.29.6.359","article-title":"An overview of ophthalmologic survey methodology in the 2008-2015 Korean national health and nutrition examination surveys","volume":"29","author":"Yoon","year":"2015","journal-title":"Korean J 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