{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:45Z","timestamp":1786119465141,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/ijg.0b013e3181ca7868","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T04:13:12Z","timestamp":1269403992000},"page":"535-539","source":"Crossref","is-referenced-by-count":6,"title":["Elevated Serum Immunoglobulin G Titers Against Chlamydia pneumoniae in Primary Open-Angle Glaucoma Patients Without Systemic Disease"],"prefix":"10.1097","volume":"19","author":[{"given":"Kenya","family":"Yuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210208","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma.","volume":"21","author":"Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"R2-7-20210208","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(88)90741-6","article-title":"Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction.","volume":"2","author":"Saikku","year":"1988","journal-title":"Lancet"},{"key":"R3-7-20210208","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(97)03079-1","article-title":"Chronic infections and coronary heart disease: is there a link.","volume":"350","author":"Danesh","year":"1997","journal-title":"Lancet"},{"key":"R4-7-20210208","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1517\/13543784.7.5.691","article-title":"Persistent infection and vascular disease: a systematic review.","volume":"7","author":"Danesh","year":"1998","journal-title":"Expert Opin Investig Drugs"},{"key":"R5-7-20210208","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/hrt.81.3.232","article-title":"Chlamydia pneumoniae and atherosclerosis.","volume":"81","author":"Wong","year":"1999","journal-title":"Heart"},{"key":"R6-7-20210208","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/bmj.321.7255.208","article-title":"Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study and meta-analysis.","volume":"321","author":"Danesh","year":"2000","journal-title":"BMJ"},{"key":"R7-7-20210208","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/bmj.321.7255.204","article-title":"Chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study.","volume":"321","author":"Wald","year":"2000","journal-title":"BMJ"},{"key":"R8-7-20210208","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/euhj.2001.2801","article-title":"Chlamydia pneumoniae IgA titres and coronary heart disease; prospective study and meta-analysis.","volume":"23","author":"Danesh","year":"2002","journal-title":"Eur Heart J"},{"key":"R9-7-20210208","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1442-9071.2006.01392.x","article-title":"Chlamydia pneumoniae and age-related macular degeneration: a role in pathogenesis or merely a chance association.","volume":"35","author":"Guymer","year":"2007","journal-title":"Clin Experiment Ophthalmol"},{"key":"R10-7-20210208","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/bjo.87.5.523","article-title":"Is Chlamydia pneumoniae infection a risk factor for age related macular degeneration.","volume":"87","author":"Ishida","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"R11-7-20210208","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archopht.121.4.478","article-title":"Serological association between Chlamydia pneumoniae infection and age-related macular degeneration.","volume":"121","author":"Kalayoglu","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"R12-7-20210208","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bjo.2008.145383","article-title":"Chlamydia pneumoniae infection, complement factor H variants and age-related macular degeneration.","volume":"93","author":"Shen","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"R13-7-20210208","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s00417-005-1169-y","article-title":"Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration.","volume":"243","author":"Kalayoglu","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R14-7-20210208","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/aje\/kwi130","article-title":"Exposure to Chlamydia pneumoniae infection and progression of age-related macular degeneration.","volume":"161","author":"Robman","year":"2005","journal-title":"Am J Epidemiol"},{"key":"R15-7-20210208","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1167\/iovs.06-1434","article-title":"Exposure to Chlamydia pneumoniae infection and age-related macular degeneration: the Blue Mountains Eye Study.","volume":"48","author":"Robman","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R16-7-20210208","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye.","volume":"134","author":"Anderson","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"R17-7-20210208","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ophtha.2006.02.062","article-title":"Open-angle glaucoma and cardiovascular mortality: the Blue Mountains Eye Study.","volume":"113","author":"Lee","year":"2006","journal-title":"Ophthalmology"},{"key":"R19-7-20210208","first-page":"1641","article-title":"The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study.","volume":"111","author":"Iwase","year":"2004","journal-title":"Ophthalmology"},{"key":"R20-7-20210208","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-695X.1996.tb00285.x","article-title":"Detection of serum antibodies against Chlamydia pneumoniae by ELISA.","volume":"14","author":"Numazaki","year":"1996","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R21-7-20210208","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0002-9394(70)90096-6","article-title":"Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test.","volume":"70","author":"Wang","year":"1970","journal-title":"Am J Ophthalmol"},{"key":"R22-7-20210208","first-page":"1107","article-title":"Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients.","volume":"26","author":"Lopez-Hoyos","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"R23-7-20210208","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jjcc.2008.07.001","article-title":"Chlamydia pneumoniae IgA and elevated level of IL-6 may synergize to accelerate coronary artery disease.","volume":"52","author":"Jha","year":"2008","journal-title":"J Cardiol"},{"key":"R24-7-20210208","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1699-0463.1995.tb01436.x","article-title":"The immunobiology and immunopathology of chlamydial infections.","volume":"103","author":"Ward","year":"1995","journal-title":"Apmis"},{"key":"R25-7-20210208","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0167-7012(00)00209-8","article-title":"The use of serologic tests for the diagnosis of chlamydial infections.","volume":"42","author":"Tuuminen","year":"2000","journal-title":"J Microbiol Methods"},{"key":"R26-7-20210208","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1469-0691.2008.02075.x","article-title":"Chlamydophila pneumoniae diagnostics: importance of methodology in relation to timing of sampling.","volume":"15","author":"Hvidsten","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"R27-7-20210208","doi-asserted-by":"crossref","first-page":"821","DOI":"10.11150\/kansenshogakuzasshi1970.70.821","article-title":"Assay of specific anti-Chlamydia pneumoniae antibodies by ELISA method. 1. Evaluation of ELISA kit using outer membrane complex.","volume":"70","author":"Kishimoto","year":"1996","journal-title":"Kansenshogaku Zasshi"},{"key":"R28-7-20210208","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3950\/jibiinkoka.101.11_1316","article-title":"Epidemiologic study of Chlamydia pneumoniae with ELISA.","volume":"101","author":"Dake","year":"1998","journal-title":"Nippon Jibiinkoka Gakkai Kaiho"},{"key":"R29-7-20210208","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/01.ATV.12.8.945","article-title":"Smoking is a potential confounder of the Chlamydia pneumoniae-coronary artery disease association.","volume":"12","author":"Hahn","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"R30-7-20210208","doi-asserted-by":"crossref","first-page":"S500","DOI":"10.1016\/S0002-8703(99)70285-1","article-title":"Epidemiology of Chlamydia pneumoniae in atherosclerosis.","volume":"138","author":"Saikku","year":"1999","journal-title":"Am Heart J"},{"key":"R32-7-20210208","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0735-1097(98)00016-3","article-title":"Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease.","volume":"31","author":"Maass","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"R33-7-20210208","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1574-6968.2002.tb11470.x","article-title":"Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells.","volume":"217","author":"MacIntyre","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"R34-7-20210208","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1161\/01.STR.0000034789.82859.A4","article-title":"Impact of infectious burden on progression of carotid atherosclerosis.","volume":"33","author":"Espinola-Klein","year":"2002","journal-title":"Stroke"},{"key":"R35-7-20210208","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1023420432020","article-title":"Dissemination of Chlamydia pneumoniae to the vessel wall in atherosclerosis.","volume":"246","author":"Hirono","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"R36-7-20210208","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.atherosclerosis.2004.08.031","article-title":"Progression of peripheral arterial occlusive disease is associated with Chlamydia pneumoniae seropositivity and can be inhibited by antibiotic treatment.","volume":"179","author":"Krayenbuehl","year":"2005","journal-title":"Atherosclerosis"},{"key":"R37-7-20210208","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma.","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"R40-7-20210208","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0002-9394(99)00028-8","article-title":"Optic nerve blood flow in glaucoma: effect of systemic hypertension.","volume":"127","author":"Grunwald","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"R41-7-20210208","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00061198-199604000-00003","article-title":"Perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open angle glaucoma.","volume":"5","author":"Michelson","year":"1996","journal-title":"J Glaucoma"},{"key":"R42-7-20210208","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/S0161-6420(84)34091-X","article-title":"Retinal autoregulation in open-angle glaucoma.","volume":"91","author":"Grunwald","year":"1984","journal-title":"Ophthalmology"},{"key":"R43-7-20210208","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/01.ijg.0000176932.06606.6e","article-title":"C-reactive protein levels in normal tension glaucoma.","volume":"14","author":"Leibovitch","year":"2005","journal-title":"J Glaucoma"},{"key":"R44-7-20210208","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1017\/S0012162206001642","article-title":"Recurrent optic neuritis associated with Chlamydia pneumoniae infection of the central nervous system.","volume":"48","author":"Pohl","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"R45-7-20210208","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1034\/j.1600-0420.2002.800618.x","article-title":"Chlamydia pneumoniae in central retinal artery occlusion.","volume":"80","author":"Vecsei","year":"2002","journal-title":"Acta Ophthalmol Scand"},{"key":"R46-7-20210208","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1136\/ard.61.11.1012","article-title":"Infectious background of patients with a history of acute anterior uveitis.","volume":"61","author":"Huhtinen","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"R47-7-20210208","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000059636","article-title":"Chlamydia in anterior ischemic optic neuropathy.","volume":"216","author":"Vecsei","year":"2002","journal-title":"Ophthalmologica"},{"key":"R48-7-20210208","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0161-6420(01)01031-4","article-title":"Chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy.","volume":"109","author":"Weger","year":"2002","journal-title":"Ophthalmology"},{"key":"R49-7-20210208","first-page":"1816","article-title":"Chlamydial antibodies in patients with previous acute anterior uveitis.","volume":"42","author":"Huhtinen","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R50-7-20210208","first-page":"293","article-title":"Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line.","volume":"13","author":"Khalyfa","year":"2007","journal-title":"Mol Vis"},{"key":"R51-7-20210208","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1167\/iovs.05-0830","article-title":"Complement component 1Q C1Q upregulation in retina of murine, primate, and human glaucomatous eyes.","volume":"47","author":"Stasi","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R52-7-20210208","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1167\/iovs.03-1123","article-title":"Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure.","volume":"45","author":"Ahmed","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R53-7-20210208","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00281-008-0112-9","article-title":"Immunopathological aspects of age-related macular degeneration.","volume":"30","author":"Patel","year":"2008","journal-title":"Semin Immunopathol"}],"container-title":["Journal of Glaucoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/IJG.0b013e3181ca7868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:13:18Z","timestamp":1786039998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00061198-201010000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/ijg.0b013e3181ca7868","relation":{},"ISSN":["1057-0829"],"issn-type":[{"value":"1057-0829","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}