{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:58:06Z","timestamp":1777737486425,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the hemodynamic effect of an off-pump Apicoaortic valved graft (AAVG) implantation, we performed a quantitative coronary flow analysis in a swine model of severe aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 10 swine, cardiac output, coronary flow, right common carotid artery flow, and internal mammary artery flow were measured along with left and right ventricular pressures and aortic and pulmonary artery pressures. A novel AAVG was implanted off-pump on the left ventricular (LV) apex using a specially designed implantation tool and anastomosed to the descending thoracic aorta. Aortic flow was measured proximally and distally of the AAVG-to-descending thoracic aorta anastomosis. After AAVG implantation, epicardial echo confirmed occlusion of the LV outflow tract by a valvuloplasty balloon. Baseline simultaneous measurements of all parameters were repeated after AAVG implantation and intravenous Dobutamine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The AAVG was implanted without any blood loss. After AAVG implantation and LV outflow tract occlusion, the aortic flow proximal to the AAVG-to-descending thoracic aorta anastomosis changed from antegrade (1508 \u00b1 435 mL\/min) to retrograde (\u2013529 \u00b1 241 mL\/min, P &lt; 0.001). All other measured parameters remained unchanged compared with baseline. After intravenous Dobutamine administration, LV pressure increased from 88 \u00b1 20 to 184 \u00b1 36 mm Hg (+209%, P &lt; 0.0001) and coronary flow increased from 75 \u00b1 34 to 193 \u00b1 90 mL\/min (+257%, P = 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The off-pump implantation of an AAVG is bloodless, safe, reproducible and has no negative impact on coronary flow and hemodynamics. In addition, to the best of our knowledge, this is the first study where blood flow in all coronary arteries was measured simultaneously during an AAVG implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/imi.0b013e31823735ba","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T15:53:02Z","timestamp":1319817182000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Off-Pump Implantation of an Apicoaortic Valved Graft is Safe and Has No Negative Impact on Coronary Flow and Hemodynamics"],"prefix":"10.1177","volume":"6","author":[{"given":"Nikolaos Tsirikos","family":"Karapanos","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott H.","family":"Suddendorf","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Huebner","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon J.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle D.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Daly","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Rochester, MN USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr1-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm095"},{"key":"bibr2-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.190748"},{"key":"bibr3-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.12.052"},{"key":"bibr4-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-191007000-00009"},{"key":"bibr5-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.11.4.564"},{"key":"bibr6-imi.0b013e31823735ba","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)41394-9"},{"key":"bibr7-imi.0b013e31823735ba","first-page":"112","volume":"5","author":"Cooley 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