{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:43:22Z","timestamp":1790037802242,"version":"4.0.1"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Specialized pro-resolving mediators (SPMs) derived from docosahexaenoic acid (DHA), particularly D-series resolvins (RvD1, RvD2, RvD3, and RvD5), function to terminate inflammation while preserving host defense. They are synthesized from DHA by lipoxygenases and act through G\u2011protein\u2011coupled receptors and lipid\u2011sensing transcription factors (TFs). These mediators reprogram macrophage metabolism towards fatty\u2011acid oxidation and oxidative phosphorylation, accelerate efferocytosis, and promote tissue repair. Here, we synthesize current knowledge on their biosynthesis, receptor signaling, and immunometabolic rewiring within macrophages, and critically appraise their therapeutic potential across cardiometabolic, musculoskeletal, autoimmune, and ischemia\/reperfusion disorders. We also discuss analytical controversies surrounding their in vivo low\u2011abundance detection, and outline translational challenges including short half\u2011life, formulation stability, and emerging synthetic agonists. Finally, we propose priority research directions, from single-cell spatial lipidomics to clinical translation, to define the next frontier for resolvin-based immunotherapies.<\/jats:p>","DOI":"10.1097\/in9.0000000000000076","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:00:21Z","timestamp":1769749221000},"page":"e00076","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["From lipid switch to tissue repair: how resolvins reprogram macrophage polarization and function"],"prefix":"10.1097","volume":"8","author":[{"given":"Rebecca","family":"Buete","sequence":"first","affiliation":[{"name":"Departments of Medicine and Physiology, Pharmacology and Therapeutics and Biomedical Engineering, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children\u2019s Hospital (JHACH), St. Petersburg, FL, 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