{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:30:58Z","timestamp":1786120258871,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Metabolic reprogramming of T lymphocytes has a decisive role in their activation, differentiation, and functional fate commitment. Metabolic reprogramming guides not only the generation of T effector and T memory cells but also the development of dysfunctional exhausted (T\n                      <jats:sub>EX<\/jats:sub>\n                      ) cells. A recent study by Haku et al published in\n                      <jats:italic toggle=\"yes\">Nature Immunology<\/jats:italic>\n                      provides new insights into the role of mitochondria in regulating the metabolic capabilities of T\n                      <jats:sub>EX<\/jats:sub>\n                      cells and their implications for antitumor immunity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/in9.0000000000000080","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:00:10Z","timestamp":1777438810000},"page":"e00080","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A new twist in metabolic T cell exhaustion"],"prefix":"10.1097","volume":"8","author":[{"given":"Konstantinos","family":"Aliazis","sequence":"first","affiliation":[{"name":"Department of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA, 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