{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:14:44Z","timestamp":1779174884190,"version":"3.51.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Metabolic dysfunction\u2013associated fatty liver disease (MAFLD) is a leading cause of hepatocellular carcinoma (HCC), driven in part by oxidative stress\u2013induced immune dysfunction that limits the efficacy of immunotherapy. In a recent study, Yu et al developed a vitamin E\u2013incorporated lipid nanoparticle designed to enhance hepatocyte\u2011specific mRNA delivery while simultaneously buffering oxidative stress in the hepatic microenvironment. By restoring the activity of the redox\u2011sensitive phosphatase T\u2011cell protein tyrosine phosphatase and suppressing signal transducer and activator of transcription (STAT) signaling, this strategy improves metabolic homeostasis, reduces inflammatory signaling, and enhances responsiveness to immune checkpoint blockade. These findings illustrate how rational nanoparticle engineering can integrate therapeutic delivery with microenvironmental reprogramming in chronic metabolic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/in9.0000000000000083","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:00:08Z","timestamp":1779174008000},"page":"e00083","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD"],"prefix":"10.1097","volume":"8","author":[{"given":"Matteo","family":"Ghiringhelli","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Zangi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"issue":"1","key":"R1-20260519","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta\u2011analytic assessment of prevalence and 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