{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:18:57Z","timestamp":1790007537438,"version":"4.0.1"},"reference-count":178,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Monoacylglycerol (MAG) is an important bioactive lipid metabolite\/intermediate, playing crucial roles in energy homeostasis and cellular signaling. This review explores MAG\u2019s chemical structure, classification, and metabolic pathways. We also discuss the emerging evidence for MAG as a signaling molecule, with particular emphasis on their interactions with cannabinoid receptor 1 and cannabinoid receptor 2 and G-protein-coupled receptor 119. We focus on examining the diverse and tissue-specific functions of MAG in the context of metabolic diseases, including the roles of MAG in nutrient absorption, appetite regulation, obesity, glucose homeostasis, and lipid metabolism. Furthermore, we address therapeutic approaches in modulating MAG metabolism and challenges in development, considering the complexity of targeting peripheral tissues. This review provides insights into the multifaceted roles of MAG in metabolic health and disease, paving the way for novel therapeutic strategies in the management of metabolic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/in9.0000000000000087","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:00:07Z","timestamp":1785898807000},"page":"e00087","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Tissue-specific roles of monoacylglycerol (MAG) in metabolic diseases"],"prefix":"10.1097","volume":"8","author":[{"given":"Min Young","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Translational Research Institute, AdventHealth, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Mooring","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Bruno","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 O.","family":"Alem\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Translational Research Institute, AdventHealth, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7]]},"reference":[{"issue":"5","key":"R1-20260805","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4062\/biomolther.2021.107","article-title":"Bioactive lipids and their derivatives in biomedical applications.","volume":"29","author":"Park","year":"2021","journal-title":"Biomol Ther (Seoul)"},{"issue":"10","key":"R2-20260805","doi-asserted-by":"crossref","first-page":"e0334213","DOI":"10.1371\/journal.pone.0334213","article-title":"Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease.","volume":"20","author":"Corbalan","year":"2025","journal-title":"PLoS 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