{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:12:39Z","timestamp":1775869959087,"version":"3.50.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The recent occurrence of congenital syphilis in Columbus, OH, raised concern for an increase in syphilis among women and infants. The objectives were to examine the rates of syphilis among men, women and infants in Ohio from 2003 to 2016 and compare these rates to the rest of the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This retrospective study evaluated cases of syphilis among men, women and infants from 2003 to 2016 using data from the Ohio Department of Health and the Centers for Disease Control and Prevention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In Ohio from 2003 to 2016, the number of all syphilis cases among women significantly increased from 153 (2.6\/100,000) to 294 (5.2\/100,000), respectively (<jats:italic toggle=\"yes\">b<\/jats:italic> = 0.26; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.001; 95% confidence interval [CI]: 0.137\u20130.382). From 2003 to 2016, congenital syphilis in Ohio also increased significantly from 3 (2\/100,000) to 13 cases (9.3\/100,000), respectively (<jats:italic toggle=\"yes\">b<\/jats:italic> = 1.05; <jats:italic toggle=\"yes\">P<\/jats:italic> \u2264 0.001; 95% CI: 0.687\u20131.408). The increase in congenital syphilis mirrored the increase in all cases of syphilis in women but not with the rates of primary and secondary syphilis. Among men, cases of primary and secondary syphilis increased significantly in Ohio and the rest of the United States, from 156 (2.8\/100,000) and 5956 (4.2\/100,000) in 2003 to 622 (10.5\/100,000) and 24,724 (15.6\/100,000) in 2016, respectively (Ohio: <jats:italic toggle=\"yes\">b<\/jats:italic> = 0.55; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; 95% CI: 0.426\u20130.679; United States: <jats:italic toggle=\"yes\">b<\/jats:italic> = 0.77; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001; 95% CI: 0.629\u20130.916).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The association of congenital syphilis with all syphilis cases in women highlights the importance of reporting all cases and not just primary and secondary syphilis. The increase in congenital syphilis reinforces the recommendation for repeat maternal screening during pregnancy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/inf.0000000000001995","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T18:30:39Z","timestamp":1521829839000},"page":"1286-1289","source":"Crossref","is-referenced-by-count":15,"title":["Re-emergence of Congenital Syphilis in Ohio"],"prefix":"10.1097","volume":"37","author":[{"given":"Joshua M.","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makeda","family":"Porter","sequence":"additional","affiliation":[{"name":"Columbus Public Health, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Bazan","sequence":"additional","affiliation":[{"name":"Columbus Public Health, Columbus, Ohio"},{"name":"Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Statistical Consulting, Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Divisions of Neonatology and Pediatric Infectious Diseases, Department of Pediatrics, Center for Perinatal Research, Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230912","first-page":"402","article-title":"Primary and secondary syphilis\u2013United States, 2005-2013.","volume":"63","author":"Patton","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R2-20230912","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1586\/14787210.2015.990384","article-title":"Syphilis in the United States: on the rise?","volume":"13","author":"Peterman","year":"2015","journal-title":"Expert Rev Anti Infect Ther"},{"key":"R3-20230912","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.15585\/mmwr.mm6444a3","article-title":"Increase in incidence of congenital syphilis \u2013 United States, 2012\u20132014.","volume":"64","author":"Bowen","year":"2015","journal-title":"Morb Mortal Wkly Rep (MMWR)"},{"key":"R5-20230912","doi-asserted-by":"crossref","first-page":"381.e1","DOI":"10.1016\/j.ajog.2015.10.007","article-title":"Congenital syphilis: trends in mortality and morbidity in the United States, 1999 through 2013.","volume":"214","author":"Su","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"14","key":"R6-20230912","first-page":"413","article-title":"Congenital syphilis \u2013 United States, 2003\u20132008.","volume":"59","year":"2010","journal-title":"Morb Mortal Wkly Rep (MMWR)"},{"issue":"2S","key":"R7-20230912","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1016\/j.japh.2017.01.001","article-title":"Strategies and policies to address the opioid epidemic: a case study of Ohio.","volume":"57","author":"Penm","year":"2017","journal-title":"J Am Pharm Assoc (2003)"},{"key":"R8-20230912","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2105\/AJPH.80.7.853","article-title":"Risk factors for syphilis: cocaine use and prostitution.","volume":"80","author":"Rolfs","year":"1990","journal-title":"Am J Public Health"},{"key":"R9-20230912","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0095-5108(18)30185-4","article-title":"Syphilis in pregnancy.","volume":"24","author":"S\u00e1nchez","year":"1997","journal-title":"Clin Perinatol"},{"key":"R10-20230912","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJM195207102470203","article-title":"The incidence of prenatal syphilis at the Boston City Hospital.","volume":"247","author":"Fiumara","year":"1952","journal-title":"N Engl J Med"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006454-201812000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T23:05:57Z","timestamp":1694559957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006454-201812000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000001995","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}