{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:40:35Z","timestamp":1787010035113,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    Cerebral amebic encephalitis due to\n                    <jats:italic toggle=\"yes\">Balamuthia mandrillaris<\/jats:italic>\n                    is a rare yet typically fatal disease. As such, identification of the clinical characteristics, appropriate diagnostic workup and commencement of treatment is frequently delayed. Here, we present a case of a 4-year-old male with a\n                    <jats:italic toggle=\"yes\">B. mandrillaris<\/jats:italic>\n                    cerebral abscess successfully treated with expedited neurosurgical resection and broad-spectrum antimicrobial therapy.\n                  <\/jats:p>","DOI":"10.1097\/inf.0000000000003418","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T22:00:11Z","timestamp":1638568811000},"page":"e54-e57","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Successful Treatment of a Balamuthia mandrillaris Cerebral Abscess in a Pediatric Patient With Complete Surgical Resection and Antimicrobial Therapy"],"prefix":"10.1097","volume":"41","author":[{"given":"Joshua A.","family":"Cuoco","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Neurosurgery, Carilion Clinic, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Neurosurgery, Carilion Clinic, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"LeBel","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Dominion Pathology Associations, Roanoke, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Faulhaber","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Infectious Diseases, Carilion Clinic, Roanoke, Virginia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Apfel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Neurosurgery, Carilion Clinic, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Witcher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Neurosurgery, Carilion Clinic, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"R1-20250615","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1128\/JCM.00875-06","article-title":"Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri.","volume":"44","author":"Qvarnstrom","year":"2006","journal-title":"J Clin Microbiol"},{"key":"R2-20250615","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1086\/379020","article-title":"Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases.","volume":"37","author":"Deetz","year":"2003","journal-title":"Clin Infect Dis"},{"key":"R3-20250615","doi-asserted-by":"crossref","first-page":"466","DOI":"10.5858\/2004-128-466-BMMIAI","article-title":"Balamuthia mandrillaris meningoencephalitis in an immunocompetent patient: an unusual clinical course and a favorable outcome.","volume":"128","author":"Jung","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"R4-20250615","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1086\/597260","article-title":"Under the radar: balamuthia amebic encephalitis.","volume":"48","author":"Schuster","year":"2009","journal-title":"Clin Infect Dis"},{"key":"R5-20250615","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1086\/653609","article-title":"Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement.","volume":"51","author":"Mart\u00ednez","year":"2010","journal-title":"Clin Infect Dis"},{"key":"R6-20250615","doi-asserted-by":"crossref","first-page":"e699","DOI":"10.1542\/peds.2009-1797","article-title":"Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient.","volume":"125","author":"Cary","year":"2010","journal-title":"Pediatrics"},{"key":"R7-20250615","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jocn.2010.11.033","article-title":"Asymptomatic aneurysm of the cavernous and supraclinoid internal carotid artery in a patient with Balamuthia mandrillaris encephalitis.","volume":"18","author":"Orozco","year":"2011","journal-title":"J Clin Neurosci"},{"key":"R8-20250615","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3171\/2010.10.JNS10677","article-title":"Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy.","volume":"114","author":"Doyle","year":"2011","journal-title":"J Neurosurg"},{"key":"R9-20250615","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1093\/jpids\/pit033","article-title":"Balamuthia mandrillaris Encephalitis: survival of a child with severe meningoencephalitis and review of the literature.","volume":"3","author":"Moriarty","year":"2014","journal-title":"J Pediatric Infect Dis Soc"},{"key":"R10-20250615","doi-asserted-by":"crossref","first-page":"e005031","DOI":"10.1099\/jmmcr.0.005031","article-title":"A Balamuthia survivor.","volume":"3","author":"Vollmer","year":"2016","journal-title":"JMM Case Rep"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000003418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T12:02:33Z","timestamp":1749988953000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000003418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000003418","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,26]]}}}