{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:40:34Z","timestamp":1787010034898,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The objective of our study was to evaluate the efficacy of treatment options for the most frequently reported complications of acute mastoiditis in the English literature. PubMed, EMBASE, and The Cochrane Library were searched from database inception through March 29, 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two independent reviewers (M.R.K., K.S.) evaluated search results for study inclusion. References cited in publications meeting inclusion criteria were reviewed. Twenty-three included studies were published from 1998 through 2018. Treatment efficacy was determined by comparing the change in number of complication subtypes in each treatment subgroup (medical, conservative, or surgical) from admission to discharge (range: 5\u201330 days) or postdischarge follow-up (range: 1\u201327.5 months) with a random effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 733 identified articles, 23 met inclusion criteria. Of the 883 included patients, 203 were managed medically (23%), 300 conservatively (34%) and 380 surgically (43%). Conservative patients had more extracranial complications (ECC,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) and intratemporal complications (IT,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) at follow-up compared with medical patients. Medical patients had more total number of complications (TNC,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), ECC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), and IT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) at discharge compared with surgical patients. Conservative patients had more of all complications except intracranial\/extracranial abscess and \u201cother\u201d at discharge and follow-up compared with surgical patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There were larger reductions in TNC, ECC, and IT at discharge and follow-up among surgical patients compared with medical and conservative patients. There were greater reductions in TNC, ECC, IT, intracranial complications, subperiosteal abscess and lateral sinus thrombosis at discharge and follow-up among surgical patients compared with conservative patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/inf.0000000000003452","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T15:18:13Z","timestamp":1645111093000},"page":"297-301","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Management of Acute Complicated Mastoiditis"],"prefix":"10.1097","volume":"41","author":[{"given":"Matthew R.","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Shetty","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ryan","family":"Camilon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Shetty","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine & Dentistry, University of Rochester, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand K.","family":"Devaiah","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Boston University, Boston, MA"},{"name":"Departments of Neurological Surgery and Ophthalmology, Boston University, Boston, MA"},{"name":"Institute for Health System Innovation and Policy, Boston University, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"R4-20250615","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00405-013-2454-8","article-title":"Mastoiditis in adults: a 19-year retrospective study.","volume":"271","author":"Palma","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R5-20250615","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/lary.27462","article-title":"Medical Versus Surgical Treatment of Pediatric Acute Mastoiditis: A Systematic Review.","volume":"129","author":"Anne","year":"2019","journal-title":"Laryngoscope"},{"key":"R6-20250615","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.jinf.2015.04.012","article-title":"Pediatric intracranial abscesses.","volume":"71 Suppl 1","author":"Bonfield","year":"2015","journal-title":"J Infect"},{"key":"R7-20250615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5876(00)00425-0","article-title":"Acute mastoiditis\u2013the antibiotic era: a multicenter study.","volume":"57","author":"Luntz","year":"2001","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R8-20250615","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1542\/peds.113.5.1451","article-title":"Diagnosis and management of acute otitis media.","volume":"113","year":"2004","journal-title":"Pediatrics"},{"key":"R9-20250615","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijporl.2007.02.014","article-title":"Acute mastoiditis: increase in the incidence and complications.","volume":"71","author":"Benito","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R10-20250615","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/000348940911800207","article-title":"Preoperative and postoperative intracranial complications of acute mastoiditis.","volume":"118","author":"Mallur","year":"2009","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"R11-20250615","doi-asserted-by":"crossref","first-page":"997; 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