{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:58:44Z","timestamp":1790441924548,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>To determine the characteristics and outcomes of postnatal cytomegalovirus (pCMV) infection in preterm infants in a neonatal intensive care unit (NICU).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A retrospective, matched case-control study in a tertiary NICU. Infants born between January 2009 and December 2019, &lt;32 weeks\u2019 gestational age (GA) and\/or birth weight (BW) &lt;1500\u2009g with pCMV infection were matched 1:1 with cytomegalovirus-(CMV)-negative infants by year of admission, gender, GA and BW. Primary outcome was death \u226436 weeks\u2019 postmenstrual age or bronchopulmonary dysplasia (BPD). Secondary outcomes were length of ventilation (LOV), length of stay (LOS) and neurodevelopmental impairment (NDI) at corrected age 1 and 2 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Forty-eight pCMV-positive infants (median GA 25.3 weeks, BW 695\u2009g, age 58 days) were identified from 1659 infants (incidence 2.9%). The most common symptoms of pCMV infection were abdominal distension (43.8%), sepsis-like syndrome (29.2%), thrombocytopenia (60.5%) and conjugated hyperbilirubinemia (60.9%). Compared with controls, there were no significant differences in the composite outcome of death or BPD (56.3% vs. 37.5%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.1) or NDI at 1 and 2 years (51.9% vs. 44%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.8; 71.4% vs. 50%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.4). pCMV-positive infants had a significantly longer median LOV (23.5 vs. 12 days)* and LOS (140 vs. 110.5 days)*. Eleven (22.9%) infants received antivirals. Ten improved and 1 died. Two untreated infants died (1 from pCMV infection).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Clinically identifiable pCMV infections are significant and associated with increased respiratory support and prolonged hospital stay in vulnerable infants. pCMV screening and preventive measures against transmission merit consideration.<\/jats:p>\n            <jats:p>*<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/inf.0000000000003531","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T21:04:59Z","timestamp":1649365499000},"page":"579-586","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Postnatal Cytomegalovirus Infection: Is it Important? A 10-Year Retrospective Case-control Study of Characteristics and Outcomes in Very Preterm and Very Low Birth Weight Infants"],"prefix":"10.1097","volume":"41","author":[{"given":"Lily","family":"Minihan","sequence":"first","affiliation":[{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Lee Oei","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Kensington"},{"name":"Department of Newborn Care, Royal Hospital for Women"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-4132","authenticated-orcid":false,"given":"Barbara","family":"Bajuk","sequence":"additional","affiliation":[{"name":"NSW Pregnancy and Newborn Services Network, Sydney Children\u2019s Hospitals 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