{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:59:45Z","timestamp":1792425585560,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Background:<\/jats:title>\n \n Helicobacter pylori<\/jats:italic> (H. pylori<\/jats:italic>) gastritis may be an incidental finding during upper endoscopy performed to diagnose celiac disease (CeD), inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE). We aimed to describe the incidence of H. pylori<\/jats:italic> in children undergoing endoscopy for CeD, IBD and EoE and determine the indications for treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective, single-center study based on the review of endoscopy reports of pediatric patients, diagnosed with CeD, IBD and EoE, between January 2017 and December 2021. Data collected included; age, gender, hematologic parameters, endoscopic, histologic and H. pylori<\/jats:italic> culture results, and information on eradication treatment.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n H. pylori<\/jats:italic> gastritis was diagnosed in 120 of 558 (21.5%) children [72 (60%) female, mean age 10.6 years] during gastroscopy performed for the diagnosis of other GI diseases. H. pylori<\/jats:italic> was present in 87 of 404 (21.5%) CeD, 27 of 113 (23.9%) IBD and 6 of 41 (14.6%) EOE patients (P<\/jats:italic> = 0.46). The main indication for treatment was the presence of ulcers, in 4 of 120 (3.3%), and erosions in 17 of 120 (14.2%). Eradication treatment was recommended in 22 of 120 (18.3%) patients, 8 of 87 (9.2%) CeD, 10 of 27 (37%) IBD and 4 of 6 (66.7%) EoE patients, P<\/jats:italic> < 0.001. Four independent positive treatment predictors were identified; age above 10 years {odds ratio (OR) = 10.57 [95% confidence interval (CI) 1.88\u201359.36], P<\/jats:italic> = 0.007} the presence of nodular gastritis (OR = 5.03 [95% CI 1.09\u201323.15], P<\/jats:italic> = 0.38), erosions [OR = 49.21 (95% CI 8.19\u2013295.83), P<\/jats:italic> < 0.000] and ulcers [OR = 22.69 (95% CI 1.25\u2013410.22), P<\/jats:italic> = 0.035]. CeD was a strong negative predictor for treatment [OR = 0.23 (95% CI 0.002\u20130.241), P<\/jats:italic> = 0.002].<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n H. pylori<\/jats:italic> gastritis is a common incidental finding during endoscopy. The indications for treatment are not well defined and should be further investigated.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/inf.0000000000004012","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T20:07:55Z","timestamp":1689710875000},"page":"833-836","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Helicobacter pylori Found Incidentally During Upper Endoscopy Performed for Diagnosis of Common Pediatric Gastrointestinal Diseases"],"prefix":"10.1097","volume":"42","author":[{"given":"Yael","family":"Dolstra","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaplan Medical Center, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaplan Medical Center, Rehovot, Israel"},{"name":"Pediatric Gastroenterology Unit, Kaplan Medical Center, Rehovot, Israel"},{"name":"Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"R1-20250614","doi-asserted-by":"crossref","first-page":"e000679","DOI":"10.1136\/bmjpo-2020-000679","article-title":"Helicobacter pylori infection in children.","volume":"4","author":"Aguilera Matos","year":"2020","journal-title":"BMJ Paediatr Open"},{"key":"R2-20250614","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/MPG.0000000000001594","article-title":"ESPGHAN, NASPGHAN. Joint ESPGHAN\/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016).","volume":"64","author":"Jones","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R3-20250614","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/apt.14561","article-title":"Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection.","volume":"47","author":"Zamani","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"R4-20250614","first-page":"e12","article-title":"Review: prevalence and dynamics of Helicobacter pylori infection during childhood.","volume":"22","author":"Zabala","year":"2017","journal-title":"Helicobacter"},{"key":"R5-20250614","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/MPG.0000000000002816","article-title":"Helicobacter pylori Working Group of ESPGHAN. Helicobacter pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016.","volume":"71","author":"Kori","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R6-20250614","article-title":"Helicobacter pylori Special Interest Group of ESPGHAN. Management of Helicobacter pylori infection in paediatric patients in Europe: results from the EuroPedHp Registry [published online ahead of print].","author":"Le Thi","year":"2022","journal-title":"Infection"},{"key":"R7-20250614","first-page":"398","article-title":"[Summary of the Israel Gastroenterology Association (IGA) guidelines for the management and treatment of Helicobacter pylori in 2019].","volume":"158","author":"Boltin","year":"2019","journal-title":"Harefuah"},{"key":"R8-20250614","doi-asserted-by":"crossref","first-page":"e12691","DOI":"10.1111\/hel.12691","article-title":"Helicobacter pylori infection in children with celiac disease: Multi-center, cross-sectional study.","volume":"25","author":"Bayrak","year":"2020","journal-title":"Helicobacter"},{"key":"R9-20250614","first-page":"10509","article-title":"Correlation between Helicobacter pylori infection and Crohn\u2019s disease: a meta-analysis.","volume":"23","author":"Wang","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R10-20250614","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cgh.2019.01.013","article-title":"Association between helicobacter pylori exposure and decreased odds of eosinophilic esophagitis-A systematic review and meta-analysis.","volume":"17","author":"Shah","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R11-20250614","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4161\/gmic.27000","article-title":"What do we know about benefits of H. pylori treatment in childhood?","volume":"4","author":"Sierra","year":"2013","journal-title":"Gut Microbes"},{"key":"R12-20250614","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1053\/j.gastro.2007.11.006","article-title":"Helicobacter pylori gastritis in children is associated with a regulatory T-cell response.","volume":"134","author":"Harris","year":"2008","journal-title":"Gastroenterology"},{"key":"R13-20250614","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/S0950268813001428","article-title":"Follow-up of Helicobacter pylori infection in children over two decades (1988-2007): persistence, relapse and acquisition rates.","volume":"142","author":"Vanderpas","year":"2014","journal-title":"Epidemiol Infect"},{"key":"R14-20250614","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1523-5378.2011.00895.x","article-title":"Inverse association between helicobacter pylori and pediatric asthma in a high-prevalence population.","volume":"17","author":"Zevit","year":"2011","journal-title":"Helicobacter"},{"key":"R15-20250614","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/j.1365-2222.2011.03831.x","article-title":"Effect of helicobacter, geohelminth infection and selected commensal bacteria on the risk of allergic disease and sensitization in 3-year-old Ethiopian children.","volume":"41","author":"Amberbir","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"R16-20250614","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2012.00010","article-title":"The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders.","volume":"2","author":"Arnold","year":"2012","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:04:34Z","timestamp":1749945874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000004012","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,11]]}}}