{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:59:50Z","timestamp":1772679590131,"version":"3.50.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Type 2 inflammatory responses are associated with worse prognosis in coccidioidomycosis. It is unclear whether patients with preexisting type 2 inflammation and atopic disorders are predisposed to disseminated coccidioidomycosis. A retrospective analysis of pediatric patients with disseminated coccidioidomycosis revealed no significant difference in the history of atopic disorders or eosinophilia as compared to those with isolated pulmonary disease. Tissue-specific type 2 responses may still play a role in coccidioidomycosis immune dysregulation, and further investigation is needed.<\/jats:p>","DOI":"10.1097\/inf.0000000000004337","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T14:39:43Z","timestamp":1711550383000},"page":"e245-e247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Atopic Disorders Among Pediatric Patients With Pulmonary and Disseminated Coccidioidomycosis"],"prefix":"10.1097","volume":"43","author":[{"given":"Sarah","family":"Zhang","sequence":"first","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-7270","authenticated-orcid":false,"given":"Brenna","family":"LaBere","sequence":"additional","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"},{"name":"Division of Pulmonology, Section of Allergy-Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Woodward","sequence":"additional","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"},{"name":"Division of Pulmonology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Ballan","sequence":"additional","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"},{"name":"Division of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine W.","family":"Perry","sequence":"additional","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"},{"name":"Division of Nephrology, Phoenix Children\u2019s Hospital, Phoenix, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-7769","authenticated-orcid":false,"given":"Keith","family":"Sacco","sequence":"additional","affiliation":[{"name":"From the University of Arizona College of Medicine\u2014Phoenix, Phoenix, Arizona"},{"name":"Division of Pulmonology, Section of Allergy-Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"R1-20250614","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.idc.2021.03.010","article-title":"Coccidioidomycosis.","volume":"35","author":"Bays","year":"2021","journal-title":"Infect Dis Clin North Am"},{"key":"R2-20250614","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3201\/eid2302.160505","article-title":"Risk factors for disseminated coccidioidomycosis, United States.","volume":"23","author":"Odio","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"R3-20250614","doi-asserted-by":"crossref","first-page":"e159491","DOI":"10.1172\/jci.insight.159491","article-title":"Immunogenetics associated with severe coccidioidomycosis.","volume":"7","author":"Hsu","year":"2022","journal-title":"JCI Insight"},{"key":"R4-20250614","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/iai.37.2.609-616.1982","article-title":"Specificity of immunoglobulin E in coccidioidomycosis and correlation with disease involvement.","volume":"37","author":"Cox","year":"1982","journal-title":"Infect Immun"},{"key":"R5-20250614","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1056\/NEJMoa2000024","article-title":"Disseminated coccidioidomycosis treated with interferon-\u03b3 and dupilumab.","volume":"382","author":"Tsai","year":"2020","journal-title":"N Engl J Med"},{"key":"R7-20250614","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0140-6736(10)61380-3","article-title":"Role of viral respiratory infections in asthma and asthma exacerbations.","volume":"376","author":"Busse","year":"2010","journal-title":"Lancet"},{"key":"R8-20250614","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/mi.2014.75","article-title":"Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33.","volume":"8","author":"Verma","year":"2015","journal-title":"Mucosal Immunol"},{"key":"R9-20250614","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.amjmed.2018.09.020","article-title":"Corticosteroids in the management of severe coccidioidomycosis.","volume":"132","author":"Chang","year":"2019","journal-title":"Am J Med"},{"key":"R10-20250614","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1093\/cid\/ciw360","article-title":"2016 Infectious Diseases Society of America (IDSA) Clinical practice guideline for the treatment of coccidioidomycosis.","volume":"63","author":"Galgiani","year":"2016","journal-title":"Clin Infect Dis"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:03:36Z","timestamp":1749945816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000004337","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,22]]}}}