{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:40:09Z","timestamp":1749944409064,"version":"3.41.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Enterococcal meningitis in children is rare, and its clinical presentation, laboratory characteristics and outcomes are not well defined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We conducted a retrospective analysis of Enterococcal meningitis cases during 2002\u20132023 at our tertiary center.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>We identified 10 cases in children 2 weeks to 15 years old (median age: 8 months). Seven children were males and 9 had comorbidities, including a ventriculoperitoneal shunt in 5 children. All children with shunt infections presented with nonspecific signs and symptoms. While 8 children presented with fever, only 3 had signs of meningeal irritation and altered consciousness. Cerebrospinal fluid pleocytosis was evident in almost all children with a median of 173 cells\/mL. Nine cases were due to <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>, and 1 case was due to <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>. All 5 children with ventriculoperitoneal shunt underwent shunt removal and replacement. All children recovered without documented sequelae.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Enterococcal meningitis is rare, especially in healthy neonates. It typically occurs following neurosurgical interventions and may only present with fever and shunt malfunction, without overt meningeal signs and with mild inflammation. The prognosis is favorable.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/inf.0000000000004342","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T22:03:01Z","timestamp":1711576981000},"page":"731-735","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Enterococcal Central Nervous System Infections in Children: A 22 Years\u2019 Experience in a Tertiary Center and Review of the Literature"],"prefix":"10.1097","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-3177","authenticated-orcid":false,"given":"Aviad","family":"Schnapp","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem"},{"name":"Pediatric Division, Department of Pediatrics, Hadassah Medical Center Jerusalem"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-4284","authenticated-orcid":false,"given":"Sergei","family":"Elber-Dorozko","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem"},{"name":"Pediatric Division, Department of Pediatrics, Hadassah Medical Center Jerusalem"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Temper","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Clinical Microbiology Laboratory"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-8426","authenticated-orcid":false,"given":"Oren","family":"Gordon","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem"},{"name":"Pediatric Division, Department of Pediatrics, Hadassah Medical Center Jerusalem"},{"name":"Department of Clinical Microbiology, Pediatric Infectious Diseases Unit, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Averbuch","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem"},{"name":"Pediatric Division, Department of Pediatrics, Hadassah Medical Center Jerusalem"},{"name":"Department of Clinical Microbiology, Pediatric Infectious Diseases Unit, Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"R1-20250614","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1542\/hpeds.2015-0187","article-title":"A meta-analysis of the rates of listeria monocytogenes and enterococcus in febrile infants.","volume":"6","author":"Leazer","year":"2016","journal-title":"Hosp Pediatr"},{"key":"R2-20250614","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jpeds.2018.04.033","article-title":"Epidemiology and etiology of invasive bacterial infection in infants \u226460 days old treated in emergency departments.","volume":"200","author":"Woll","year":"2018","journal-title":"J Pediatr"},{"key":"R3-20250614","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1442-200X.2010.03107.x","article-title":"Eleven-year study of causes of neonatal bacterial meningitis in Ahvaz, Iran.","volume":"52","author":"Aletayeb","year":"2010","journal-title":"Pediatr Int"},{"key":"R4-20250614","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1542\/peds.85.2.165","article-title":"Enterococcal sepsis in neonates: features by age at onset and occurrence of focal infection.","volume":"85","author":"Dobson","year":"1990","journal-title":"Pediatrics"},{"key":"R5-20250614","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijid.2016.07.010","article-title":"Clinical and pathogenic analysis of 507 children with bacterial meningitis in Beijing, 2010 \u2013 2014.","volume":"50","author":"Guo","year":"2022","journal-title":"Int J Infect Dis"},{"key":"R6-20250614","doi-asserted-by":"crossref","first-page":"e15398","DOI":"10.1111\/ped.15398","article-title":"Experience with enterococcal meningitis\/ventriculitis in children.","volume":"65","author":"\u00c7ay","year":"2023","journal-title":"Pediatr Int"},{"key":"R7-20250614","first-page":"270","article-title":"Systemic group D streptococcal infection in newborn infants.","volume":"133","author":"Buchino","year":"1979","journal-title":"Am J Dis Child"},{"key":"R8-20250614","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1001\/archinte.1978.03630360033017","article-title":"Non-group D streptococcal meningitis misidentified as enterococcal meningitis. 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